Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Zhang, Shulin ^a,b,c   Wang, Yucheng ^a   Mao, Jian Hua ^d   Hsieh, David ^a   Kim, Il Jin ^a   Hu, Li Min ^e   Xu, Zhidong ^a   Long, Hao ^a   Jablons, David M ^a   You, Liang ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CASEIN KINASE II; MESSENGER RNA; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC CORRELATION; GLI1 GENE; HH GENE; HUMAN; HUMAN CELL; LUNG CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION;

ATP-BINDING CASSETTE TRANSPORTERS; CARCINOMA, NON-SMALL-CELL LUNG; CASEIN KINASE II; CELL COUNT; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; LUNG NEOPLASMS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; PROTEIN KINASE INHIBITORS; PROTEOLYSIS; SIDE-POPULATION CELLS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

ERINACEIDAE;

EID: 84863093578     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038996     Document Type: Article

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