Anesthesia-related neurotoxicity and the developing animal brain is not a significant problem in children

Paediatric Anaesthesia

Volumn 25, Issue 1, 2015, Pages 65-72

  Hansen, Tom G ^a,b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

age: infants; general anesthesia; neonates; neurodevelopment; outcome

Indexed keywords

ANESTHETIC AGENT;

ANESTHESIA; BRAIN DEVELOPMENT; COHORT ANALYSIS; HUMAN; NEUROTOXICITY; NONHUMAN; REVIEW; ADVERSE EFFECTS; BRAIN; CHILD; GROWTH, DEVELOPMENT AND AGING; PATHOLOGY; SPECIES DIFFERENCE; TOXICITY AND INTOXICATION;

ANESTHESIA; ANESTHETICS; BRAIN; CHILD; HUMANS; NEUROTOXICITY SYNDROMES; SPECIES SPECIFICITY;

EID: 84916213324     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/pan.12548     Document Type: Review

References (40)

1. Ikonomidou C, Bosch F, Miksa M, et al,. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999; 283: 70-74.
2. Lunardi N, Ori C, Erisir A, et al,. General anesthesia causes long-lasting disturbances in ultrastructural properties of developing synapses in young rats. Neurotox Res 2010; 17: 179-188.
3. Vutskits L, Davis PJ, Hansen TG,. Anesthetics and the developing brain: time for a change in practice? A pro/con debate Pediatr Anesth 2012; 22: 973-980.
4. Vutskits L,. General anesthesia: a gateway to modulate synapse formation and neural plasticity? Anesth Analg 2012; 115: 1174-1182.
5. Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al,. Early exposure to common anesthetic agents causes widespread neurodegeneration the developing rat brain and persistent learning deficits. J Neurosci 2003; 23: 876-882.
6. Paule MG, Li M, Allen RR, et al,. Ketamine anesthesia during the first week of life can cause long lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol 2011; 33: 220-230.
7. Slikker W Jr, Zou X, Hotchkiss CE, et al,. Ketamine anesthesia during neuronal cell death in the perinatal rhesus monkey. Toxicol Sci 2007; 98: 145-158.
8. Zou X, Liu F, Zhang X, et al,. Inhalational anesthetic-induced neuronal damage in the developing rhesus monkey. Neurotoxicol Teratol 2011; 33: 592-599.
9. Wu B, You S, Zhenq Y, et al,. Physiological disturbance may contribute to neurodegeneration induced by isoflurane or sevoflurane in 14 day old rats. PLoS ONE 2014; 9: e84622.
10. Pound P, Bracken MB,. Is animal research sufficiently evidence based to be a cornerstone of biomedical research? BMJ 2014; 348: g3387.
11. Rizzi S, Ori C, Jevtovic-Todorovic V,. Timing versus duration: determinants of anesthesia-induced developmental apoptosis in young mammalian brain. Ann N Y Acad Sci 2010; 1199: 43-51.
12. Clancy B, Darlington RB, Finlay BL,. Translating developmental brain development across mammalian species. Neuroscience 2001; 105: 7-17.
13. Clancy B, Finlay BL, Darlington RB, et al,. Extrapolating brain development from experimental species to humans. Neurotoxicology 2007; 28: 931-937.
14. Hofacer RD, Deng M, Ward CG, et al,. Cell-age specific vulnerability of neurons to anesthetic toxicity. Ann Neurol 2013; 73: 695-704.
15. Deng M, Hofacer RD, Jiang C, et al,. Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions. Br J Anaesth 2014; 113: 443-451.
16. Ing CH, DiMaggio C, Malacova E, et al,. Comparative analysis of outcome measures used in examining neurodevelopmental effects of early childhood anesthesia exposure. Anesthesiology 2014; 120: 1319-1332.
17. Flick RF, Nemergut ME, Christensen K, et al,. Anesthetic-related neurotoxicity in the young and outcome measures. The devil is in the details. Anesthesiology 2014; 120: 1303-1305.
18. Sprung J, Flick RF, Katusic SK, et al,. Attention-deficit/hyperactivity disorder after early exposure to procedures requiring general anesthesia. Mayo Clin Proc 2012; 87: 120-129.
19. Visser SN, Blumberg SJ, Danielson ML, et al,. State-based and demographic in parent-reported medication rates for attention deficit/hyperactivity disorder, 2007-2008. Prev Chronic Dis 2013; 10: 20073.
20. Visser SN, Danielson ML, Bitsko RH, et al,. Trends in parent-report of health care provider-diagnosed and medicated attention deficit/hyperactivity disorder: United States, 2003-2011. J Am Acad Child Adolesc Psychiatry 2014; 53: 34-46 e2.
21. Ko WR, Huang JY, Chiang YC, et al,. Risk of autistic disorder after exposure to general Anaesthesia and surgery: a nationwide retrospective matched cohort study. Eur J Anaesthesiol 2014. [Epub ahead of print].
22. Loepke AW, Hansen TG,. Is this our (paediatric patient's) brain on anaesthetic drugs? The search for a potential neurological phenotype of anaesthesia-related neurotoxicity in humans. Eur J Anaesthesiol 2014. (in press).
23. Hansen TG,. Neurotoxicity, general anesthesia and the developing brain: what have we learned from the human studies so far? Curr Anesthesiol Rep 2013; 3: 175-183.
24. Wilder RT, Flick RP, Sprung J, et al,. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology 2009; 110: 796-804.
25. DiMaggio C, Sun LS, Kakavouli A, et al,. A retrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children. J Neurosurg Anesthesiol 2009; 21: 286-291.
26. Flick RP, Katusic SK, Colligan RC, et al,. Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics 2011; 128: e1053-e1061.
27. Sprung J, Flick RP, Wilder RT, et al,. Anesthesia for cesarian delivery and learning disability in a population-based birth cohort. Anesthesiology 2009; 111: 302-310.
28. DiMaggio C, Sun LS, Li G,. Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. Anesth Analg 2011; 113: 1143-1151.
29. Ing C, DiMaggio C, Whitehouse A, et al,. Long-term differences in language and cognitive function after childhood exposure to anesthesia. Pediatrics 2012; 130: e476-e485.
30. Bartels M, Althoff RR, Boomsma DI,. Anesthesia and cognitive performance in children: no evidence for a causal relationship. Twin Res Hum Genet 2009; 12: 246-253.
31. Hansen TG, Pedersen JK, Henneberg SW, et al,. Academic performance in adolescence after inguinal hernia repair in infancy: a nationwide cohort study. Anesthesiology 2011; 114: 1076-1085.
32. Hansen TG, Pedersen JK, Henneberg SW, et al,. Educational outcome in adolescence following pyloric stenosis repair before 3 months of age: a nationwide cohort study. Pediatr Anesth 2013; 23: 883-890.
33. Kalkman CJ, Peelen L, Moons KG, et al,. Behavior and development in children and age at the time of first anesthetic exposure. Anesthesiology 2009; 110: 805-812.
34. Stratman G, Lee J, Sall JW, et al,. Effect of general anesthesia in infancy on long-termrecognition memory in humans and rats. Neuropsychopharmacology 2014; 39: 2275-2287.
35. Block RI, Thomas JJ, Bayman EO, et al,. Are anesthesia and surgery during infancy associated with altered academic performance during childhood. Anesthesiology 2012; 117: 494-503.
36. Katusic SK, Colligan RC, Barbaresi WJ, et al,. Potential influence on migration bias in birth cohort studies. Mayo Clin Proc 1998; 73: 1053-1061.
37. Hansen TG, Pedersen JK, Henneberg SE, et al,. Neurosurgical conditions and procedures in infancy significantly impact mortality and academic performances in adolescence: a nation-wide cohort study. Pediatr Anesth 2014. (in press).
38. Lewis MS, Maruff P, Silbert BS, et al,. Detection of postoperative decline after coronary bypass graft surgery is affected by the number of neuropsychological tests in the assessment battery. Ann Thorac Surg 2006; 81: 2097-2104.
39. Selnes OA, Gottesman RF, Grega MA, et al,. Cognitive and neurologic outcome after coronary-bypass surgery. N Engl J Med 2012; 366: 250-257.
40. Weiss M, Bissonnette B, Engelhardt T, et al,. Anesthetists rather than anesthetics are the threat to the baby brains. Pediatr Anesth 2013; 23: 881-882.