Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways

Journal of Pathology

Volumn 235, Issue 1, 2015, Pages 101-112

  Choudhary, Mayur ^a   Kazmin, Dmitri ^b   Hu, Peng ^a   Thomas, Russell S ^c   McDonnell, Donald P ^d   Malek, Goldis ^a,d  

^a DUKE UNIVERSITY EYE CENTER   (United States)

^b EMORY UNIVERSITY   (United States)

^c HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Age related macular degeneration; Angiogenesis; Aryl hydrocarbon receptor; Choroidal neovascularization; Extracellular matrix; Inflammation; RNA sequencing

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CALCIUM ION; CHEMOKINE; COLLAGEN TYPE 4; OSTEOPONTIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN A;

AGE RELATED MACULAR DEGENERATION; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MICROGLIA; MIGRATION; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN SECRETION; RNA SEQUENCE; SIGNAL TRANSDUCTION; SUBRETINAL NEOVASCULARIZATION; VISUAL IMPAIRMENT; WILD TYPE; ANIMAL; C57BL MOUSE; CELL MOTION; CHOROID; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; MACULAR DEGENERATION; METABOLISM; RETINAL PIGMENT EPITHELIUM;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; CHOROID; CHOROIDAL NEOVASCULARIZATION; GENE EXPRESSION REGULATION; HUMANS; MACULAR DEGENERATION; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ARYL HYDROCARBON; RETINAL PIGMENT EPITHELIUM; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84916207341     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4433     Document Type: Article

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