Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Cusick, Sarah E ^a   Opoka, Robert O ^a,b   Lund, Troy C ^a   John, Chandy C ^a   Polgreen, Lynda E ^c  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MAKERERE UNIVERSITY   (Uganda)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; HYDROXYCOLECALCIFEROL;

ARTICLE; BLOOD SAMPLING; BRAIN MALARIA; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOASSAY; MALARIA; MALE; PREVALENCE; SEVERE MALARIAL ANEMIA; UGANDA; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; BLOOD; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; INFANT; INNATE IMMUNITY; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PROSPECTIVE STUDY; RISK FACTOR;

CHILD; CHILD, PRESCHOOL; HUMANS; HYDROXYCHOLECALCIFEROLS; IMMUNITY, INNATE; INFANT; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PROSPECTIVE STUDIES; RISK FACTORS; UGANDA; VITAMIN D DEFICIENCY;

EID: 84915770978     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113185     Document Type: Article

References (19)

1. Hewison M (2010) Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 39(2): 365-379.
2. Nnoaham KE, Clarke A (2008) Low serum vitamin D levels and tuburculosis: a systematic review and meta-analysis. Int J Epidemiol 37(1): 113-119.
3. Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, et al. (2013) Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis. BMC Infectious Diseases 13: 22.
4. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, et al. (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311: 1770-1773.
5. Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, et al. (2011) High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 377: 242-250.
6. Khare D, Godbole NM, Pawar SD, Mohan V, Pandey G, et al. (2013) Calcitriol [1, 25[OH]2 D3] pre- and post-treatment suppresses inflammatory response to influenza A (H1N1) infection in human lung A549 epithelial cells. Eur. J. Nutr. 52: 1405-1415.
7. Barlow PG, Svoboda P, Mackellar A, Nash AA, York IA, et al. (2011) Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PloS One 6: e25333.
8. Chua CLL, Brown G, Hamilton JA, Rogerson S, Boeuf P (2013) Monocytes and macrophages in malaria: protection or pathology? Trends Parasitol 29: 26-34.
9. Parra M, Liu X, Derrick SC, Yang A, Tian J, et al. (2013) Molecular analysis of non-specific protection against murine malaria induced by BCG vaccination. PloS One 8: e66115.
10. Cippitelli M, Santoni A (1998) Vitamin D3: a transcriptional modulator of the interferon-gamma gene. Eur. J. Immunol 28: 3017-3030.
11. Cohen ML, Douvdevani A, Chaimovitz C, Shany S (2001) Regulation of TNF-alpha by 1alpha,25-dihydroxyvitamin D3 in human macrophages from CAPD patients. Kidney Int 59: 69-75.
12. Dickie LJ, Church LD, Coulthard LR, Mathews RJ, Emery P et al. (2010) Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatol Oxf Engl 49: 1466-1471.
13. He X, Yan J, Zhu X, Wang Q, Wei P, et al. (2014) Vitamin D inhibits the occurrence of experimental cerebral malaria in mice by suppressing the host inflammatory response. J Immunol published online 25 June 2014.
14. Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87(4): p. 1080S-6S.
15. Amukele TK, Soko D, Katundu P, Kamanga M, Sun J, et al. (2013) Vitamin D levels in Malawian infants from birth to 24 months. Arch Dis Child 98: 180-183.
16. Gordon CM, Feldman HA, Sinclair L, Williams AL, Kleinman PK, et al. (2008) Prevalence of vitamin D deficiency among healthy infants and toddlers. Arch Pediatr Adolec Med 162(6): 505-512.
17. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, et al. (2013) Vitamin D-binding status of black Americans and white Americans. N Engl J Med 369(21): 1991-2000.
18. Newens K, Filteau S, Tomkins A (2006) Plasma 25-hydroxyvitamin D does not vary over the course of a malarial infection. Trans R Soc Trop Med Hyg 100(1): 41-4 Epub 2005 Sep 19.
19. Weintraub SJ, Chen Y, Bouillon R, Jones K, Schoenmakers I, et al. (2014) Correspondence. Vitamin D-Binding Protein and Vitamin D in Blacks and Whites N Engl J Med 370: 878-881February 27, 2014 doi:10.1056/NEJMc1315850.