Sustained increase in α5GABAa receptor function impairs memory after anesthesia

Journal of Clinical Investigation

Volumn 124, Issue 12, 2014, Pages 5437-5441

  Zurek, Agnieszka A ^a   Yu, Jieying ^a   Wang, Dian Shi ^a   Haffey, Sean C ^a   Bridgwater, Erica M ^a   Penna, Antonello ^a   Lecker, Irene ^a   Lei, Gang ^a   Chang, Tom ^a   Salter, Eric W R ^a   Orser, Beverley A ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DEXMEDETOMIDINE; ETOMIDATE; GABRA5 PROTEIN, MOUSE; INHALATION ANESTHETIC AGENT; ISOFLURANE;

AMNESIA; ANESTHESIA COMPLICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN FUNCTION; CELL SURFACE; CONTROLLED STUDY; DEPRESSION; DRUG DOSE; FACILITATION; GENERAL ANESTHESIA; HIPPOCAMPAL CA1 REGION; MENTAL PERFORMANCE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; POSTSYNAPTIC POTENTIAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RECOGNITION; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; COGNITIVE DEFECT; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; KNOCKOUT MOUSE; MEMORY DISORDER; METABOLISM; PATHOLOGY; TIME;

ANESTHESIA, GENERAL; ANESTHETICS, INHALATION; ANIMALS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; ISOFLURANE; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; RECEPTORS, GABA-A; TIME FACTORS;

EID: 84915750039     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76669     Document Type: Article

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