Nanosuspension Development of scutellarein as an active and rapid orally absorbed precursor of its BCS class IV glycoside scutellarin

Journal of Pharmaceutical Sciences

Volumn 103, Issue 11, 2014, Pages 3576-3584

  Yang, Xiao ^a   Miao, Xiaoqing ^a   Cao, Fangrui ^b   Li, Shang ^a   Ai, Nana ^a   Chang, Q I ^b   Lee, Simon M Y ^a   Zheng, Ying ^a  

^a University of Macau   (Macao)

^b PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Absorption; Cerebral hemorrhage; Metabolism; Nanotechnology; Oral drug delivery; Precursor; Scutellarin (SG); Solubility; Zebrafish

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; POLOXAMER; SCUTELLAREIN; SCUTELLARIN; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; APIGENIN; BETA CYCLODEXTRIN DERIVATIVE; EXCIPIENT; GLUCURONIC ACID; NANOMATERIAL; PRODRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN HEMORRHAGE; CONTROLLED STUDY; DISPERSION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG SOLUBILITY; FREEZE DRYING; ISOMER; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MEMBRANE PERMEABILITY; NONHUMAN; PARTICLE SIZE; PRECIPITATION; RAT; ZEBRA FISH; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; BIOTRANSFORMATION; BLOOD; CEREBRAL HEMORRHAGE; CHEMISTRY; DISEASE MODEL; MEDICINAL CHEMISTRY; NANOTECHNOLOGY; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; APIGENIN; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CEREBRAL HEMORRHAGE; CHEMISTRY, PHARMACEUTICAL; DISEASE MODELS, ANIMAL; EXCIPIENTS; FREEZE DRYING; GLUCURONATES; NANOSTRUCTURES; NANOTECHNOLOGY; PARTICLE SIZE; POLOXAMER; PRODRUGS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; ZEBRAFISH;

EID: 84915748170     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24149     Document Type: Article

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