A self-microemulsifying drug delivery system to overcome intestinal resveratrol toxicity and presystemic metabolism

Journal of Pharmaceutical Sciences

Volumn 103, Issue 11, 2014, Pages 3491-3500

  Seljak, Katarina Bolko ^a   Berginc, Katja ^b   Trontelj, Jurij ^a   Zvonar, Alenka ^a   Kristl, Albin ^a   Gašperlin, Mirjana ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b Lek dd   (Slovenia)

Author keywords

Caco 2 cells; Dissolution; Drug delivery systems; Gastrointestinal; Lipids; Phase diagram; Self emulsifying; Solubility; Surfactants

Indexed keywords

CASTOR OIL; DRUG METABOLITE; HYDROGENATED CASTOR OIL; MACROGOL STEARATE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; OCTANOIN; RESVERATROL; ACYLGLYCEROL; DRUG CARRIER; EMULSION; MULTIDRUG RESISTANCE PROTEIN; OCTANOIC ACID DERIVATIVE; STILBENE DERIVATIVE; SURFACTANT;

ANIMAL TISSUE; ARTICLE; CACO 2 CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DISPERSION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG METABOLISM; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL TOXICITY; IN VITRO STUDY; INTESTINE MUCOSA PERMEABILITY; JEJUNUM; MALE; MICROEMULSION; NONHUMAN; RAT; SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; VISCOSITY; ANIMAL; CHEMISTRY; EMULSION; HUMAN; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; METABOLISM; PERMEABILITY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; CACO-2 CELLS; CAPRYLATES; CASTOR OIL; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EMULSIONS; GLYCERIDES; HUMANS; INTESTINAL ABSORPTION; JEJUNUM; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; STILBENES; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY;

EID: 84914815494     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24114     Document Type: Article

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