Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance

Journal of Neuroscience

Volumn 34, Issue 49, 2014, Pages 16273-16285

  Cui, Wanpeng ^a   Mizukami, Hiroaki ^b   Yanagisawa, Michiko ^a   Aida, Tomomi ^a   Nomura, Masatoshi ^c   Isomura, Yoshikazu ^d   Takayanagi, Ryoichi ^c   Ozawa, Keiya ^b   Tanaka, Kohichi ^a,e   Aizawa, Hidenori ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d TAMAGAWA UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Astrocytes; Depression; Glutamate transporters; Habenula; Monoamines; Rapid eye movement sleep

Indexed keywords

DIHYDROKAINIC ACID; EXCITATORY AMINO ACID TRANSPORTER; NEUROFILAMENT PROTEIN; NEURON SPECIFIC NUCLEAR PROTEIN; PARVOVIRUS VECTOR; PLASMID DNA; PROTEIN C FOS; PROTEIN S100B; VESICULAR GLUTAMATE TRANSPORTER 1; DIHYDROKAWAIN; EXCITATORY AMINO ACID TRANSPORTER 2; NEUROTRANSMITTER UPTAKE INHIBITOR; PYRONE DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AVOIDANCE BEHAVIOR; BRAIN DYSFUNCTION; BRAIN STEM; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DOPAMINERGIC NERVE CELL; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; GENE DELETION; GENOTYPING TECHNIQUE; GLIAL DYSFUNCTION; HABENULA; HISTOPATHOLOGY; IMMOBILITY; LOCOMOTION; MALE; MONOAMINERGIC SYSTEM; MOUSE; NERVE CELL EXCITABILITY; NERVE CONDUCTION; NONHUMAN; NOVELTY SUPPRESSED FEEDING TEST; OPEN FIELD TEST; PATHOPHYSIOLOGY; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REM SLEEP; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTONINERGIC NERVE CELL; SLEEP DISORDER; SLEEP PATTERN; SLEEP STAGE; SPIKE WAVE; TAIL SUSPENSION TEST; ACTION POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; MICROINJECTION; NERVE CELL; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; DEPRESSION; EXCITATORY AMINO ACID TRANSPORTER 2; HABENULA; MICE; MICE, TRANSGENIC; MICROINJECTIONS; NEURONS; NEUROTRANSMITTER UPTAKE INHIBITORS; PYRONES; SLEEP, REM;

EID: 84914689044     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1465-14.2014     Document Type: Article

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