Insulin-like growth factor i signaling for brain recovery and exercise ability in brain ischemic rats

Medicine and Science in Sports and Exercise

Volumn 43, Issue 12, 2011, Pages 2274-2280

  Chang, Heng Chih ^a   Yang, Yea Ru ^a   Wang, Paulus S ^a   Kuo, Chia Hua ^b   Wang, Ray Yau ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b UNIVERSITY OF TAIPEI   (Taiwan)

Author keywords

brain ischemia; infarct volume; Insulin like growth factor I; motor function; phosphorylated Akt; treadmill training

Indexed keywords

3 BROMO 5 TERT BUTYL 4 HYDROXYBENZYLIDENEMALONONITRILE; INSULIN LIKE GROWTH FACTOR 1, RAT; INSULIN-LIKE GROWTH FACTOR-1, RAT; PROTEIN KINASE B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TYRPHOSTIN;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; CORPUS STRIATUM; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MOTOR ACTIVITY; MOTOR CORTEX; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN ISCHEMIA; CORPUS STRIATUM; INSULIN-LIKE GROWTH FACTOR I; MOTOR ACTIVITY; MOTOR CORTEX; PHYSICAL CONDITIONING, ANIMAL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1; TYRPHOSTINS;

EID: 81355138837     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e318223b5d9     Document Type: Article

References (38)

1. Antal A, Chaieb L, Moliadze V, et al. Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans. Brain Stimul. 2010;3(4):230-7.
2. Bondanelli M, Ambrosio MR, Onofri A, et al. Predictive value of circulating insulin-like growth factor I levels in ischemic stroke outcome. J Clin Endocrinol Metab. 2006;91(10):3928-34. (Pubitemid 44536866)
3. Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296(5573):1655-7. (Pubitemid 34579158)
4. Carro E, Nunez A, Busiguina S, Torres-Aleman I. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci. 2000;20(8):2926-33. (Pubitemid 30220318)
5. Carro E, Trejo JL, Busiguina S, Torres-Aleman I. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci. 2001;21(15):5678-84. (Pubitemid 32692166)
6. Cechetti F, Fochesatto C, Scopel D, et al. Effect of a neuroprotective exercise protocol on oxidative state and BDNF levels in the rat hippocampus. Brain Res. 2008;1188:182-8.
7. Chang HC, Yang YR, Wang SG, Wang RY. Effects of treadmill training on motor performance and extracellular glutamate level in striatum in rats with or without transient middle cerebral artery occlusion. Behav Brain Res. 2009;205(2):450-5.
8. Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD. A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke. 1986;17(4):738-43. (Pubitemid 16066549)
9. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25(6): 295-301. (Pubitemid 34667010)
10. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999;13(22):2905-27.
11. Ding Q, Vaynman S, Akhavan M, Ying Z, Gomez-Pinilla F. Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function. Neuroscience. 2006;140(3): 823-33. (Pubitemid 43767460)
12. Ding Y, Li J, Lai Q, et al. Motor balance and coordination training enhances functional outcome in rat with transient middle cerebral artery occlusion. Neuroscience. 2004;123(3):667-74. (Pubitemid 38045403)
13. Frystyk J. Exercise and the growth hormone-insulin-like growth factor axis. Med Sci Sports Exerc. 2010;42(1):58-66.
14. Glasper ER, Llorens-Martin MV, Leuner B, Gould E, Trejo JL. Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus. Hippocampus. 2010;20(6): 706-12.
15. Guan J, Bennet L, Gluckman PD, Gunn AJ. Insulin-like growth factor-1 and post-ischemic brain injury. Prog Neurobiol. 2003; 70(6):443-62. (Pubitemid 37249426)
16. Guan J, Miller OT, Waugh KM, McCarthy DC, Gluckman PD. Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia-ischemia in rats. Neuroscience. 2001;105(2): 299-306. (Pubitemid 32728114)
17. Jia Y, Gall CM, Lynch G. Presynaptic BDNF promotes postsynaptic long-term potentiation in the dorsal striatum. J Neurosci. 2010;30(43):14440-5.
18. Jiang Y, Wei N, Lu T, Zhu J, Xu G, Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience. 2011;172:398-405.
19. Juul A. Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res. 2003;13(4): 113-70. (Pubitemid 36986557)
20. Lin TN, He YY, Wu G, Khan M, Hsu CY. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke. 1993;24(1):117-21. (Pubitemid 23014393)
21. Magistretti PJ, Pellerin L. Cellular mechanisms of brain energy metabolism. Relevance to functional brain imaging and to neurodegenerative disorders. Ann N Y Acad Sci. 1996;777:380-7.
22. McCusker RH, McCrea K, Zunich S, et al. Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons. J Neuroimmunol. 2006; 179(1-2):186-90. (Pubitemid 44441590)
23. Menzies SA, Hoff JT, Betz AL. Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery. 1992;31(1):100-6; discussion 106-7.
24. Nakajima S, Ohsawa I, Ohta S, Ohno M, Mikami T. Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. Behav Brain Res. 2010; 211(2):178-84.
25. Nindl BC, Pierce JR. Insulin-like growth factor I as a biomarker of health, fitness, and training status. Med Sci Sports Exerc. 2010; 42(1):39-49.
26. Nunez A, Carro E, Torres-Aleman I. Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons. J Neurophysiol. 2003;89(6):3008-17. (Pubitemid 36682653)
27. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 6th ed. In: Plates and Figures. San Diego (CA): Harcourt Brace Jovanovich; 2007. p. 11-30.
28. Peurala SH, Airaksinen O, Huuskonen P, et al. Effects of intensive therapy using gait trainer or floor walking exercises early after stroke. J Rehabil Med. 2009;41(3):166-73.
29. Peurala SH, Airaksinen O, Jakala P, Tarkka IM, Sivenius J. Effects of intensive gait-oriented physiotherapy during early acute phase of stroke. J Rehabil Res Dev. 2007;44(5):637-48.
30. Ploughman M, Granter-Button S, Chernenko G, Tucker BA, Mearow KM, Corbett D. Endurance exercise regimens induce differential effects on brain-derived neurotrophic factor, synapsin-I and insulin-like growth factor I after focal ischemia. Neuroscience. 2005;136(4):991-1001. (Pubitemid 41790515)
31. Ploughman M, Windle V, MacLellan CL, White N, Dore JJ, Corbett D. Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke. 2009;40(4):1490-5.
32. Quartu M, Serra MP, Boi M, Melis T, Ambu R, Del Fiacco M. Brain-derived neurotrophic factor (BDNF) and polysialylated-neural cell adhesion molecule (PSA-NCAM): codistribution in the human brainstem precerebellar nuclei from prenatal to adult age. Brain Res. 2010;1363:49-62.
33. Rabinovsky ED, Draghia-Akli R. Insulin-like growth factor I plasmid therapy promotes in vivo angiogenesis. Mol Ther. 2004; 9(1):46-55. (Pubitemid 38208327)
34. Rizk NN, Myatt-Jones J, Rafols J, Dunbar JC. Insulin like growth factor-1 (IGF-1) decreases ischemia-reperfusion induced apoptosis and necrosis in diabetic rats. Endocrine. 2007;31(1):66-71. (Pubitemid 350194197)
35. Torres-Aleman I. Serum growth factors and neuroprotective surveillance: focus on IGF-1. Mol Neurobiol. 2000;21(3):153-60. (Pubitemid 32434068)
36. Trejo JL, Carro E, Torres-Aleman I. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J Neurosci. 2001;21(5): 1628-34. (Pubitemid 32182203)
37. Wang RY, Yang YR, Yu SM. Protective effects of treadmill training on infarction in rats. Brain Res. 2001;922(1):140-3.
38. Yang YR, Wang RY, Wang PS, Yu SM. Treadmill training effects on neurological outcome after middle cerebral artery occlusion in rats. Can J Neurol Sci. 2003;30(3):252-8. (Pubitemid 37064522)