MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1

Hypertension

Volumn 64, Issue 4, 2014, Pages 839-845

  Luo, Rongcan ^a,b   Shao, Xuan ^a,e   Xu, Peng ^a,e   Liu, Yanlei ^a,e   Wang, Yongqing ^c   Zhao, Yangyu ^c   Liu, Ming ^a   Ji, Lei ^a   Li, Yu Xia ^a   Chang, Cheng ^b   Qiao, Jie ^c   Peng, Chun ^d   Wang, Yan Ling ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b LANZHOU UNIVERSITY   (China)

^c PEKING UNIVERSITY THIRD HOSPITAL   (China)

^d YORK UNIVERSITY   (Canada)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

KCMF1; MiR 210; Placenta; Preeclampsia; TNF a

Indexed keywords

KCMF1 PROTEIN, HUMAN; MICRORNA; MIRN210 MICRORNA, HUMAN; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN PROTEIN LIGASE;

ADULT; CELL LINE; DOWN REGULATION; DRUG EFFECTS; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; PLACENTA; PREECLAMPSIA; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; CELL LINE; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MICRORNAS; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-PROTEIN LIGASES;

EID: 84914682894     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.03530     Document Type: Article

References (49)

1. de Swiet J. Maternal mortality: Confidential enquiries into maternal deaths in the united kingdom. Am J Obstet Gynecol. 2000;182: 760-766.
2. Redman CW. Current topic: Pre-eclampsia and the placenta. Placenta. 1991 12: 301-308.
3. Walker JJ. Pre-eclampsia. Lancet. 2000;356: 1260-1265.
4. Pipkin FB, Roberts J. Hypertension in pregnancy. J Hum Hypertens. 2000;14: 705-724.
5. Redline RW, Patterson P. Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol. 1995;26: 594-600.
6. Myatt L. Role of placenta in preeclampsia. Endocrine 2002;19: 103-111.
7. Fisher SJ. The placental problem: Linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol. 2004;2: 53.
8. Cui Y, Wang W, Dong N, et al. Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature. 2012;484: 246-250.
9. de Groot CJ, O'Brien TJ, Taylor RN. Biochemical evidence of impaired trophoblastic invasion of decidual stroma in women destined to have preeclampsia. Am J Obstet Gynecol Obstet. 1996;175: 24-29.
10. Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 2004;116: 281-297.
11. Bartel DP. MicroRNAs: Target recognition and regulatory functions. Cell. 2009;136: 215-233.
12. Ivan M, Harris AL, Martelli F, Kulshreshtha R. Hypoxia response and microRNAs: No longer two separate worlds. J Cell Mol Med. 2008;12(5A): 1426-1431.
13. Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, Agosto- Perez FJ, Davuluri R, Liu CG, Croce CM, Negrini M, Calin GA, Ivan M. A microRNA signature of hypoxia. Mol Cell Biol. 2007;27: 1859-1867.
14. Zhang Z, Sun H, Dai H, et al. MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle. 2009;8: 2756-2768.
15. Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 2009;10: 273-284.
16. Huang X, Le QT, Giaccia AJ. MiR-210-micromanager of the hypoxia pathway. Trends Mol Med. 2010;16: 230-237.
17. Giannakakis A, Sandaltzopoulos R, Greshock J, Liang S, Huang J, Hasegawa K, Li C, O'Brien-Jenkins A, Katsaros D, Weber BL, Simon C, Coukos G, Zhang L. miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther. 2008;7: 255-264.
18. Fasanaro P, D'Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, Capogrossi MC, Martelli F. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem. 2008;283: 15878-15883.
19. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 2009;69: 1221-1229.
20. Pineles BL, Romero R, Montenegro D, Tarca AL, Han YM, Kim YM, Draghici S, Espinoza J, Kusanovic JP, Mittal P, Hassan SS, Kim CJ. Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia. Am J Obstet Gynecol. 2007;196: 261.e1-261.e6.
21. Enquobahrie DA, Abetew DF, Sorensen TK, Willoughby D, Chidambaram K, Williams MA. Placental microRNA expression in pregnancies complicated by preeclampsia. Am J Obstet Gynecol. 2011;204: 178.e12-178.e21.
22. Zhu XM, Han T, Sargent IL, Yin GW, Yao YQ. Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies. Am J Obstet Gynecol. 2009;200: 661.e1-661.e7.
23. Anton L, Olarerin-George AO, Schwartz N, Srinivas S, Bastek J, Hogenesch JB, Elovitz MA. miR-210 inhibits trophoblast invasion and is a serum biomarker for preeclampsia. Am J Pathol. 2013;183: 1437-1445.
24. Zhang Y, Fei M, Xue G, Zhou Q, Jia Y, Li L, Xin H, Sun S. Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: New insights into molecular mechanisms for the disease. J Cell Mol Med. 2012;16: 249-259.
25. Xu P, Zhao Y, Liu M, Wang Y, Wang H, Li YX, Zhu X, Yao Y, Wang H, Qiao J, Ji L, Wang YL. Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy. Hypertension. 2014;63: 1276-1284.
26. Beilke S, Oswald F, Genze F, Wirth T, Adler G, Wagner M. The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Oncogene. 2010;29: 4058-4067.
27. Kreppel M, Aryee DN, Schaefer KL, Amann G, Kofler R, Poremba C, Kovar H. Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells. Oncogene. 2006;25: 2795-2800.
28. Jang JH. FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers. FEBS Lett. 2004;578: 21-25.
29. Kagiya T, Nakamura S. Expression profiling of microRNAs in RAW264.7 cells treated with a combination of tumor necrosis factor alpha and RANKL during osteoclast differentiation. J Periodontal Res. 2013;48: 373-385.
30. Bernardi F, Guolo F, Bortolin T, Petronilho F, Dal-Pizzol F. Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia. J Obstet Gynaecol Res. 2008;34: 948-951.
31. Todt JC, Yang Y, Lei J, Lauria MR, Sorokin Y, Cotton DB, Yelian FD. Effects of tumor necrosis factor-alpha on human trophoblast cell adhesion and motility. Am J Reprod Immunol. 1996;36: 65-71.
32. Meekins JW, McLaughlin PJ, West DC, McFadyen IR, Johnson PM. Endothelial cell activation by tumour necrosis factor-alpha (TNF-alpha) and the development of pre-eclampsia. Clin Exp Immunol. 1994;98: 110-114.
33. Brian K. Rinehart, Dom A. Terrone, Sandhya Lagoo-Deenadayalan, William H. Barber, Enatra A. Hale b, James N. Martin, Jr, Bennett. WA. Expression of the placental cytokines tumor necrosis factor a, interleukin 1ß, and interleukin 10 is increased in preeclampsia. Am J Obstet Gynecol. 1999;181: 915-920.
34. Chen G, R Wilson, Wang SH, Zheng HZ, Walker JJ, McKillop JH. Tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and expression in pre-eclampsia. Clin Exp Immunol. 1996;104: 154-159.
35. Chelbi ST, Vaiman D. Genetic and epigenetic factors contribute to the onset of preeclampsia. Mol Cell Endocrinol. 2008;282: 120-129.
36. Chan YC, Banerjee J, Choi SY, Sen CK. miR-210: The master hypoxamir. Microcirculation. 2012;19: 215-223.
37. Chan SY, Loscalzo J. Micro-RNA-210: A unique and pleiotropic hypoxamir. Cell Cycle. 2010;9: 1072-1083.
38. Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, Meenakshisundaram G, Kuppusamy P, Friedman A, Sen CK. Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds. Proc Natl Acad Sci U S A. 2010;107: 6976-6981.
39. Tsuchiya S, Fujiwara T, Sato F, Shimada Y, Tanaka E, Sakai Y, Shimizu K, Tsujimoto G. MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1). J Biol Chem. 2011;286: 420-428.
40. Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell. 2009;35: 856-867.
41. Bai Y, Yang W, Yang HX, Liao Q, Ye G, Fu G, Ji L, Xu P, Wang H, Li YX, Peng C, Wang YL. Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRIIA expression. PLoS One. 2012;7: E38875.
42. Redova M, Poprach A, Besse A, Iliev R, Nekvindova J, Lakomy R, Radova L, Svoboda M, Dolezel J, Vyzula R, Slaby O. MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma. Tumour Biol. 2013;34: 481-491.
43. Roberts JM, Gammill HS. Preeclampsia: Recent insights. Hypertension. 2005;46: 1243-1249.
44. Hung TH, Skepper JN, Charnock-Jones DS, Burton GJ. Hypoxiareoxygenation: A potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res. 2002;90: 1274-1281.
45. Saito S, Sakai M. Th1/Th2 balance in preeclampsia. J Reprod Immunol. 2003;59: 161-173.
46. Jamaluddin M, Wang S, Boldogh I, Tian B, Brasier AR. TNF-alphainduced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway. Cell Signal. 2007;19: 1419-1433.
47. Moe GW, Marin-Garcia J, Konig A, Goldenthal M, Lu X, Feng Q. In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. Am J Physiol Heart Circ Physiol. 2004;287: H1813-H1820.
48. Kim JH, Park SG, Song SY, Kim JK, Sung JH. Reactive oxygen species- responsive mir-210 regulates proliferation and migration of adiposederived stem cells via ptpn2. Cell Death Dis. 2013;4.
49. Kopriva SE, Chiasson VL, Mitchell BM, Chatterjee P. TLR3-induced placental miR-210 down-regulates the STAT6/interleukin-4 pathway. PLoS One. 2013;8: E67760.