Efficacy of polyunsaturated fatty acids for dry eye syndrome: A meta-analysis of randomized controlled trials

Nutrition Reviews

Volumn 72, Issue 10, 2014, Pages 662-671

  Zhu, Wei ^a,b   Wu, Yan ^a,c   Li, Guigang ^a   Wang, Juan ^a   Li, Xinyu ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b the Second People s Hospital of Changshu   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Dry eye syndrome; Meta analysis; Polyunsaturated fatty acids

Indexed keywords

POLYUNSATURATED FATTY ACID; UNSATURATED FATTY ACID;

ARTICLE; CLINICAL EXAMINATION; CONJUNCTIVA EPITHELIUM; DRUG EFFICACY; DRY EYE; EYE REDNESS; FOREIGN BODY; HLA SYSTEM; HUMAN; LABORATORY TEST; LACRIMATION DISORDER; META ANALYSIS; OCULAR SURFACE DISEASE; OUTCOME ASSESSMENT; PHOTOPHOBIA; RANDOMIZED CONTROLLED TRIAL (TOPIC); SENSITIVITY ANALYSIS; TEAR FILM; ANIMAL; DIET SUPPLEMENTATION; DIET THERAPY; QUALITY OF LIFE;

ANIMALS; DIETARY SUPPLEMENTS; DRY EYE SYNDROMES; FATTY ACIDS, UNSATURATED; HUMANS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84914176044     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/nure.12145     Document Type: Article

References (40)

1. Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol. 2000;118:1264-1268.
2. Schaumberg DA, Sullivan DA, Buring JE, etal. Prevalence of dry eye syndrome among US women. Am J Ophthalmol. 2003;136:318-326.
3. Galor A, Feuer W, Lee DJ, etal. Depression, post-traumatic stress disorder, and dry eye syndrome: a study utilizing the national United States Veterans Affairs administrative database. Am J Ophthalmol. 2012;154:340-346.
4. Torpy JM, Lynm C, Golub RM. JAMA patient page. Dry eye. JAMA. 2012;308:632. doi: 10.1001/jama.2012.6221.
5. Lan W, Tong L. Acupuncture has effect on increasing tear break-up time: acupuncture for treating dry eye, a randomized placebo-controlled trial. Acta Ophthalmol. 2012;90:e73. doi: 10.1111/j.1755-3768.2011.02201.x.
6. Reddy P, Grad O, Rajagopalan K. The economic burden of dry eye: a conceptual framework and preliminary assessment. Cornea. 2004;23:751-761.
7. Research in dry eye: report of the Research Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5:179-193.
8. Emmungil H, Kalfa M, Zihni FY, etal. Interstitial cystitis: a rare manifestation of primary Sjögren's syndrome, successfully treated with low dose cyclosporine. Rheumatol Int. 2012;32:1215-1218.
9. Jackson MA, Burrell K, Gaddie IB, etal. Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A. Clin Ophthalmol. 2011;5:1201-1206.
10. Thies F, Garry JM, Yaqoob P, etal. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet. 2003;361:477-485.
11. Trebble TM, Arden NK, Wootton SA, etal. Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. Am J Clin Nutr. 2004;80:1137-1144.
12. Cortina MS, Bazan HE. Docosahexaenoic acid, protectins and dry eye. Curr Opin Clin Nutr Metab Care. 2011;14:132-137.
13. Miljanovic B, Trivedi KA, Dana MR, etal. Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr. 2005;82:887-893.
14. Jacobson TA. Role of n-3 fatty acids in the treatment of hypertriglyceridemia and cardiovascular disease. Am J Clin Nutr. 2008;87:1981S-1990S.
15. Szajewska H, Horvath A, Koletzko B. Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2006;83:1337-1344.
16. Liberati A, Altman DG, Tetzlaff J, etal. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6:e1000100. doi: 10.1371/journal.pmed.1000100.
17. Higgins JP, Altman DG, Gotzsche PC, etal. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. doi: 10.1136/bmj.d5928.
18. Wojtowicz JC, Butovich I, Uchiyama E, etal. Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. Cornea. 2011;30:308-314.
19. Aragona P, Bucolo C, Spinella R, etal. Systemic omega-6 essential fatty acid treatment and PGE1 tear content in Sjögren's syndrome patients. Invest Ophthalmol Vis Sci. 2005;46:4474-4479.
20. Larmo PS, Jarvinen RL, Setala NL, etal. Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. J Nutr. 2010;140:1462-1468.
21. Barabino S, Rolando M, Camicione P, etal. Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Cornea. 2003;22:97-101.
22. Theander E, Horrobin DF, Jacobsson LT, etal. Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome. Scand J Rheumatol. 2002;31:72-79.
23. Creuzot C, Passemard M, Viau S, etal. Improvement of dry eye symptoms with polyunsaturated fatty acids. J Fr Ophtalmol. 2006;29:868-873.
24. Pinheiro MN Jr, dos Santos PM, dos Santos RC, etal. Oral flaxseed oil (Linum usitatissimum) in the treatment for dry-eye Sjögren's syndrome patients [in Portuguese]. Arq Bras Oftalmol. 2007;70:649-655.
25. ®, a per os omega-3 and omega-6 polyunsaturated essential fatty acid dietary formulation versus placebo in patients with bilateral treated moderate dry eye syndrome [in French]. J Fr Ophtalmol. 2011;34:448-455.
26. Brignole-Baudouin F, Baudouin C, Aragona P, etal. A multicentre, double-masked, randomized, controlled trial assessing the effect of oral supplementation of omega-3 and omega-6 fatty acids on a conjunctival inflammatory marker in dry eye patients. Acta Ophthalmol. 2011;89:e591-e597.
27. Bidoli E, Talamini R, Bosetti C, etal. Macronutrients, fatty acids, cholesterol and prostate cancer risk. Ann Oncol. 2005;16:152-157.
28. van Gool CJ, Thijs C, Henquet CJ, etal. Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis - a randomized controlled trial in infants at high familial risk. Am J Clin Nutr. 2003;77:943-951.
29. Barnard ND, Cohen J, Jenkins DJ, etal. A low-fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74-wk clinical trial. Am J Clin Nutr. 2009;89:1588S-1596S.
30. Viau S, Maire MA, Pasquis B, etal. Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. Graefes Arch Clin Exp Ophthalmol. 2009;247:1039-1050.
31. Kokke KH, Morris JA, Lawrenson JG. Oral omega-6 essential fatty acid treatment in contact lens associated dry eye. Cont Lens Anterior Eye. 2008;31:141-146. quiz 170.
32. Arciniega JC, Nadji EJ, Butovich IA. Effects of free fatty acids on meibomian lipid films. Exp Eye Res. 2011;93:452-459.
33. Jarvinen RL, Larmo PS, Setala NL, etal. Effects of oral sea buckthorn oil on tear film fatty acids in individuals with dry eye. Cornea. 2011;30:1013-1019.
34. He J, Bazan HE. Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery. Prostaglandins Leukot Essent Fatty Acids. 2010;82:319-325.
35. Epstein SP, Gadaria-Rathod N, Wei Y, etal. HLA-DR expression as a biomarker of inflammation for multicenter clinical trials of ocular surface disease. Exp Eye Res. 2013;111:95-104.
36. Lemp MA. Advances in understanding and managing dry eye disease. Am J Ophthalmol. 2008;146:350-356.
37. Solomon A, Dursun D, Liu Z, etal. Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci. 2001;42:2283-2292.
38. Shim J, Park C, Lee HS, etal. Change in prostaglandin expression levels and synthesizing activities in dry eye disease. Ophthalmology. 2012;119:2211-2219.
39. Pinazo-Duran MD, Galbis-Estrada C, Pons-Vazquez S, etal. Effects of a nutraceutical formulation based on the combination of antioxidants and omega-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders. Clin Interv Aging. 2013;8:139-148.
40. Rashid S, Jin Y, Ecoiffier T, etal. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. Arch Ophthalmol. 2008;126:219-225.