Efficacy assessment of Nutrilarm®, a per os omega-3 and omega-6 polyunsaturated essential fatty acid dietary formulation versus placebo in patients with bilateral treated moderate dry eye syndrome;Èvaluation de l'efficacité du Nutrilarm®, complément nutritionnel à base d'acides gras essentiels polyinsaturés oméga 3 et oméga 6, versus placebo chez des patients atteints de sécheresse oculaire bilatérale modérée et traitée

Journal Francais d'Ophtalmologie

Volumn 34, Issue 7, 2011, Pages 448-455

  Creuzot Garcher, C ^a   Baudouin, C ^b   Labetoulle, M ^c   Pisella, P J ^d   Mouriaux, F ^e   Meddeb Ouertani, A ^f   El Matri, L ^g   Khairallah, M ^h   Brignole Baudouin, F ⁱ  

^a DIJON UNIVERSITY HOSPITAL   (France)

^b CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^c BICÊTRE HOSPITAL   (France)

^d Paris 5 Descartes University EA 2496 U F R of Odontology   (France)

^e CHU CÔTE DE NACRE   (France)

^f HÔPITAL CHARLES NICOLLE   (France)

^g Institut Hedi Rais d'Ophtalmologie   (Tunisia)

^h FATTOUMA BOURGUIBA UNIVERSITY HOSPITAL   (Tunisia)

ⁱ UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Dry eye syndrome; Nutrition; Omega 3; Omega 6

Indexed keywords

NUTRILARM; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DRY EYE; ELEMENTAL DIET; FEMALE; HOSPITALIZATION; HUMAN; MALE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; DRY EYE SYNDROMES; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; FOOD, FORMULATED; HUMANS; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX;

EID: 80052586758     PISSN: 01815512     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jfo.2011.01.018     Document Type: Article

References (33)

1. S. Roncin L'œil sec Rev Prat 51 2001 140 147
2. M.B. Abelson, G.W. Ousler III, and C. Maffei Dry eye in 2008 Curr Opin Ophthalmol 20 2009 282 286
3. C. Creuzot-Garcher La sécheresse oculaire liée aux médications systémiques J Fr Ophtalmol 32 2009 64 70
4. M.A. Lemp, C. Baudouin, J. Baum, M. Dogru, G.N. Foulks, and S. Kinoshita The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye workshop Ocul Surf 5 2007 75 92 (Pubitemid 351902651)
5. C. Baudouin, F. Brignole, F. Becquet, P.J. Pisella, and A. Goguel Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammation Invest Ophthalmol Vis Sci 38 1997 1458 1464 (Pubitemid 27278566)
6. C. Baudouin The pathology of dry eye Surv Ophthalmol 45 2001 S211 S220
7. C. Baudouin Dry eye: an unexpected inflammatory disease Arch Soc Esp Oftalmol 76 2001 205 206
8. F. Brignole, P.J. Pisella, M. Goldschild, M. De Saint-Jean, A. Goguel, and C. Baudouin Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes Invest Ophthalmol Vis Sci 41 2000 1356 1363 (Pubitemid 30261857)
9. M.E. Stern, J. Gao, T.A. Schwalb, M. Ngo, D.D. Tieu, and C.C. Chan Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye Invest Ophthalmol Vis Sci 43 2002 2609 2614 (Pubitemid 34809449)
10. S. Liotet, O.P. van Bijsterveld, O. Kogbe, and L. Laroche A new hypothesis on tear film stability Ophthalmologica 195 1987 119 124
11. S.C. Pflugfelder, A. Solomon, and M.E. Stern The diagnosis and management of dry eye: a 25-year review Cornea 19 2000 644 649
12. Roncin S, Mage F, Youinou P, Pennec YL, Jouquan J, Colin J. Le traitement médical actuel de l'œil sec. J Fr Ophtalmol 1995;18:708-13, 715-30.
13. M. Calonge The treatment of dry eye Surv Ophthalmol 45 2001 S227 S239
14. C. Baudouin, P.J. Pisella, and M. De Saint-Jean Syndromes secs et surface oculaire J Fr Ophtalmol 22 1999 893 902 (Pubitemid 29510439)
15. P. Marsh, and S.C. Pflugfelder Topical non preserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren syndrome Ophthalmology 106 1999 811 816 (Pubitemid 30194327)
16. S.C. Pflugfelder Anti-inflammatory therapy for dry eye Am J Ophthalmol 137 2004 337 342
17. A. Gil Polyunsaturated fatty acids and inflammatory diseases Biomed Pharmacother 56 2002 388 396 (Pubitemid 35232741)
18. C.F. Boerner, P.R. Honan, R. Ambrosio Jr., S.K. Stelzner, and D.J. McIntyre Omega-3 fatty acid therapy for dry eye: clinical results 2002 American Society of Cataract and Refractive (ASCRS) Annual Meeting Philadelphia, USA p. 1
19. D.F. Horrobin, A. Campbell, and C.G. McEwen Treatment of the Sicca syndrome and Sjogren's syndrome with EFA, pyridoxine and vitamin C Prog Lipid Res 20 1981 253 254
20. R. Manthorpe, P.S. Hagen, and J.U. Prause Primary Sjogren's syndrome treated with Efamol/Efavit. A double-blind cross-over investigation Rheumatol Int 4 1984 165 167 (Pubitemid 14034296)
21. P. Oxholm, R. Manthorpe, J.U. Prause, and D. Horrobin Patients with primary Sjogren's syndrome treated for 2 months with evening primrose oil Scand J Rheumatol 15 1986 103 108 (Pubitemid 16048707)
22. D.F. Horrobin, and A. Campbell Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C Med Hypotheses 6 1980 225 232 (Pubitemid 10057419)
23. C. Creuzot, M. Passemard, S. Viau, C. Joffre, P. Pouliquen, and P.P. Elena Amélioration de la symptomatologie chez des patients atteints de sécheresse oculaire et traités oralement par des acides gras polyinsaturés J Fr Ophtalmol 29 2006 868 873 (Pubitemid 44673321)
24. Ambrosio RJ, Stelzner SK, Boerner CF, Honan PR, McIntyre DJ. Nutrition and dry eye: the role of lipids. Review Refract Surg 2002;29-32.
25. S. Barabino, M. Rolando, P. Camicione, G. Ravera, S. Zanardi, and S. Giuffrida Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component Cornea 22 2003 97 101 (Pubitemid 36701907)
26. B.D. Sullivan, J.M. Cermak, R.M. Sullivan, A.S. Papas, J.E. Evans, and M.R. Dana Correlations between nutrient intake and the polar lipid profiles of meibomian gland secretions in women with Sjogren's syndrome Adv Exp Med Biol 506 Pt A 2002 441 447 (Pubitemid 36307704)
27. K.A. Trivedi, M.R. Dana, J.P. Gilbard, J.E. Buring, and D.A. Schaumberg Dietary omega-3 fatty acid intake and risk of clinically diagnosed dry eye syndrome in women 2003 ARVO Fort Lauderdale, USA 811/B786
28. S. Viau, M.A. Maire, B. Pasquis, S. Gregoire, N. Acar, and A.M. Bron Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model Graefes Arch Clin Exp Ophthalmol 247 2009 1039 1050
29. C. Schnebelen, S. Gregoire, B. Pasquis, C. Joffre, C.P. Creuzot-Garcher, and A.M. Bron Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels Lipids 44 2009 465 470
30. P. Aragona, C. Bucolo, R. Spinella, S. Giuffrida, and G. Ferreri Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren's syndrome patients Invest Ophthalmol Vis Sci 46 2005 4474 4479 (Pubitemid 44264541)
31. K.H. Kokke, J.A. Morris, and J.G. Lawrenson Oral omega-6 essential fatty acid treatment in contact lens associated dry eye Cont Lens Anterior Eye 31 2008 141 146
32. B. Miljanovic, K.A. Trivedi, M.R. Dana, J.P. Gilbard, J.E. Buring, and D.A. Schaumberg Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women Am J Clin Nutr 82 2005 887 893 (Pubitemid 43779705)
33. S. Drouault-Holowacz, S. Bieuvelet, A. Burckel, D. Rigal, C. Dubray, and J.L. Lichon Antioxidants intake and dry eye syndrome: a crossover, placebo-controlled, randomized trial Eur J Ophthalmol 19 2009 337 342