HLA-DR expression as a biomarker of inflammation for multicenter clinical trials of ocular surface disease

Experimental Eye Research

Volumn 111, Issue , 2013, Pages 95-104

  Epstein, Seth P ^a   Gadaria Rathod, Neha ^a   Wei, Yi ^a   Maguire, Maureen G ^b   Asbell, Penny A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Dry eye; Feasibility; HLA DR; Impression cytology; Precision; Reliability; Repeatability; Storage

Indexed keywords

HLA DR ANTIGEN;

CELL COUNT; CRYOPRESERVATION; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; DRY EYE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; IMPRESSION CYTOLOGY; INFLAMMATION; MULTICENTER STUDY (TOPIC); OCULAR SURFACE DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); SHORT SURVEY; STANDARDIZATION;

BIOLOGICAL MARKERS; CLINICAL TRIALS AS TOPIC; DRY EYE SYNDROMES; FEASIBILITY STUDIES; FLOW CYTOMETRY; HLA-DR ANTIGENS; HUMANS; INFLAMMATION; KERATITIS; MULTICENTER STUDIES AS TOPIC; REPRODUCIBILITY OF RESULTS; SEVERITY OF ILLNESS INDEX;

EID: 84876702871     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.03.018     Document Type: Short Survey

References (56)

1. Athmanathan S., Bandlapally S.R., Gullapalli N.R. Collection of corneal impression cytology directly on a sterile glass slide for the detection of viral antigen: an inexpensive and simple technique for the diagnosis of HSV epithelial keratitis - a pilot study. BMC Ophthalmol. 2001, 1(3):1471-1476.
2. Barabino S., Montaldo E., Solignani F., Valente C., Mingari M.C., Rolando M. Immune response in the conjunctival epithelium of patients with dry eye. Exp. Eye Res. 2010, 91(4):524-529.
3. Baudouin C., Haouat N., Brignole F., et al. Immunopathological findings in conjunctival cells using immunofluorescence staining of impression cytology specimens. Br. J. Ophthalmol. 1992, 76:545-549.
4. Baudouin C., Brignole F., Becquet F., Pisella P.J., Goguel A. Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammation. Invest. Ophthalmol. Vis. Sci. 1997, 38(7):1458-1464.
5. Baudouin C., Bourcier T., Brignole F., et al. Correlation between tear IgE levels and HLA-DR expression by conjunctival cells in allergic and nonallergic chronic conjunctivitis. Graefes Arch. Clin. Exp. Ophthalmol. 2000, 238(11):900-904.
6. Baudouin C., Brignole F., Pisella P.J., De Jean M.S., Goguel A. Flow cytometric analysis of the inflammatory marker HLA DR in dry eye syndrome: results from 12 months of randomized treatment with topical cyclosporin A. Adv. Exp. Med. Biol. 2002, 506(B):761-769.
7. Beuerman R.W., Zhou L., Weon S.R., Chew J., Zhou L., Zhu H., Riau A.K. Biomarkers and proteomics in corneal cell biology. Acta Ophthalmol. 2011, 89:s248.
8. Clin. Pharmacol. Ther. 2001, 69:89-95. Biomarkers Definitions Working Group.
9. Brignole F., De Saint-Jean M., Goldschild M., Becqet F., Goguel A., Baudouin C. Expression of Fas-Fas ligand antigens and apoptotic marker APO2-7 by the human conjunctival epithelium. Positive correlation with class II HLA DR expression in inflammatory ocular surface disorders. Exp. Eye Res. 1998, 67:687-697.
10. Brignole F., Pisella P.J., Goldschild M., De Saint Jean M., Goguel A., Baudouin C. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest. Ophthalmol. Vis. Sci. 2000, 41(6):1356-1363.
11. Brignole F., Pisella P.J., De Saint Jean M., Goldschild M., Goguel A., Baudouin C. Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporine A. Invest. Ophthalmol. Vis. Sci. 2001, 42(1):90-95.
12. Brignole-Baudouin F., Ott A.C., Warnet J.M., Baudouin C. Flow cytometry in conjunctival impression cytology: a new tool for exploring ocular surface pathologies. Exp. Eye Res. 2004, 78:473-481.
13. Brignole-Baudouin F., Pisella P.J., Dupas B., Baeyens V., Baudouin C. Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. Graefes Arch. Clin. Exp. Ophthalmol. 2004, 243:531-538.
14. Brignole-Baudouin F., Baudouin C., Aragona P., Rolando M., Labetoulle M., Pisella P.J., Barabino S., Siou-Mermet R., Creuzot-Garcher C. Amulticentre, double-masked, randomized, controlled trial assessing the effect of oral supplementation of omega-3 and omega-6 fatty acids on a conjunctival inflammatory marker in dry eye patients. Acta Ophthalmol. 2011, 89(7):591-597. Epub 2011 Aug 11. 10.1111/j.1755-3768.2011.02196.x.
15. Calonge M., Diebold Y., Saez V., et al. Impression cytology of the ocular surface: a review. Exp. Eye Res. 2004, 78:457-472.
16. Chaglasian E.L. The evolving role of biomarkers. Rev. Cornea Contact Lens 2011, 11:18. http://www.reviewofcontactlenses.com/content/c/31008/.
17. De Saint Jean M., Baudouin C., Di Nolfo M., et al. Comparison of morphological and functional characteristics of primary-cultured human conjunctival epithelium and of Wong-Kilbourne derivative of Chang conjunctival cell line. Exp. Eye Res. 2004, 78(2):257-274.
18. Definition and Classification Subcommittee of the International Dry Eye Workshop The definition and classification of dry eye disease: report of the definition and classification subcommittee of the International Dry Eye Workshop. Ocul. Surf. 2007, 5(2):75-92.
19. Definition and Classification Subcommittee of the International Dry Eye Workshop The epidemiology of dry eye disease: report of the definition and classification subcommittee of the International Dry Eye Workshop. Ocul. Surf. 2007, 5:93-107.
20. Egbert P.R., Lauber S., Maurice D.M. Asimple conjunctival biopsy. Am. J. Ophthalmol. 1977, 84:798-801.
21. Fernandez K., Raynor G.S., Sheyman A.T., Epstein S.P., Massingale M.L., Dentone P.G., Asbell P.A. Modulation of HLA-DR in dry eye subjects following 30 days of treatment with a novel artificial tear product. Curr. Eye Res. 2013, (submitted for publication).
22. Goronzy J.J., Weyand C.M. Long-term immunomodulatory effects of T lymphocyte depletion in patients with systemic sclerosis. Arthritis Rheum. 1990, 33(4):511-519.
23. Guglielminetti E., Barabino S., Monaco M., Mantero S., Rolando M. HLA-DR expression in conjunctival cells after latanoprost. J.Ocul. Pharmacol. Ther. 2002, 18(1):1-9.
24. Ichikawa Y., Shimizu H., Yoshida M., Arimori S. Activation antigens expressed on T-cells of the peripheral blood in Sjogren's syndrome and rheumatoid arthritis. Clin. Exp. Rheumatol. 1990, 8(3):243-249.
25. Ishihara K., Yoshimura M., Nakao H., Kanakura Y., Kanayama Y., Matsuzawa Y. Tcell abnormalities in mixed connective tissue disease complicated with Klinefelter's syndrome. Intern. Med. 1994, 33(11):714-717.
26. Jaraquemada D., Ollier W., Awad J., Young A., Festenstein H. HLA and rheumatoid arthritis: susceptibility or severity?. Dis. Markers 1986, 4(1-2):43-53.
27. Jester J.V., Ho-Chang J. Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control invitro contractility and extracellular matrix contraction. Exp. Eye Res. 2003, 77(5):581-592.
28. Lopin E., Deveney T., Asbell P.A. Impression cytology: recent advances and applications in dry eye disease. Ocul. Surf. J. 2009, 7(2):93-110.
29. Massingale M.L., Li X., Vallabhajosyula M., Chen D., Wei Y., Asbell P.A. Analysis of inflammatory cytokines in the tears of dry eye patients. Cornea 2009, 28(9):1023-1027.
30. McKelvie P. Ocular surface impression cytology. Adv. Anal. Pathol. 2003, 10(6):328-337.
31. Mrugacz M., Zak J., Bakunowicz-Lazarczyk A., Wysocka J., Minarowska A. Flow cytometric analysis of HLA-DR antigen in conjunctival epithelial cells of patients with cystic fibrosis. Eye (Lond.) 2007, 21(8):1062-1066.
32. Natadisastra G., Wittpenn J.R., West K.P., et al. Impression cytology for detection of vitamin A deficiency. Arch. Ophthalmol. 1987, 105:1224-1228.
33. Natadisastra G., Wittpenn J.R., Muhilal, West K.P., Mele L., Sommer A. Impression cytology: a practical index of vitamin A status. Am. J. Clin. Nutr. 1988, 48(3):695-701.
34. Nelson D.J., Havener V.R., Cameron J.D. Cellulose acetate impressions of the ocular surface: dry eye states. Arch. Ophthalmol. 1983, 101:1869-1872.
35. Newman P.J. The biology of PECAM-1. J.Clin. Invest. 1997, 100:S25-S29.
36. Nolan G.R., Hirst L.W., Wright R.G., et al. Application of impression cytology to the diagnosis of conjunctival neoplasms. Diagn. Cytopathol. 1994, 11:246-249.
37. Pauly A., Brignole-Baudouin F., Labbé A., Liang H., Warnet J.M., Baudouin C. New tools for the evaluation of toxic ocular surface changes in the rat. Invest. Ophthalmol. Vis. Sci. 2007, 48(12):5473-5483.
38. Pietersz R.N., Loos J.A., Reesink H.W. Survival invivo of platelets stored for 48 hours in the buffycoat at 4 degrees C compared to platelet rich plasma stored at 22 degrees C. Blut 1987, 54(4):201-206.
39. Pisella P.J., Brignole F., Debbasch C., Lozato P.A., Creuzot-Garcher C., Bara J., et al. Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca. Ophthalmology 2000, 107(10):1841-1849.
40. Puangsricharern V., Tseng S.C. Cytological evidence of corneal diseases with limbal stem cell deficiency. Ophthalmology 1995, 102:1476-1485.
41. Rivas L., Murube J., Rivas A., Shalaby O. Contribución de la citología de impresión al diagnóstico del penfigoide cicatricial ocular en sus primeras fases. Arch. Soc. Esp. Oftalmol. 2004, 79(2):67-74. 0365-6691.
42. Rolando M., Barabino S., Mingari C., Moretti S., Giuffrida S., Calabria G. Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes. Cornea 2005, 24(8):951-954.
43. Roy P., Cimbolini N., Feraille L., Elena P.P. Evaluation of membranes material for impression cytology. Invest. Ophthalmol. Vis. Sci. 2011, 52(4):S1937.
44. Roy P., Cimbolini N., Feraille L., Elena P.P., Baudouin C. Evaluation of membranes material for impression cytology. Invest. Ophthalmol. Vis. Sci. 2012, 53(4):S1868.
45. Sanchez M.A., Arriola-Villalobos P., Torralbo-Jimmenez P., et al. The effect of preservative-free HP-Guar on dry eye after phacoemulsification: a flow cytometric study. Eye (Lond.) 2010, 24:1331-1337.
46. Singh R., Joseph A., Umapathy T., et al. Impression cytology of the ocular surface. Br. J. Ophthalmol. 2005, 89:1655-1659.
47. Stern M.E., Gao J., Schwalb T.A., et al. Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye. Invest. Ophthalmol. Vis. Sci. 2002, 43(8):2609-2614.
48. Stevenson D., Tauber J., Reis B.L. Efficacy and safety of cyclosporin A ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease: a dose-ranging, randomized trial: the Cyclosporine Phase 2 Study Group. Ophthalmology 2000, 107(5):967-974.
49. Thiel M.A., Bossart W., Bernauer W. Improved impression cytology techniques for the immunopathological diagnosis of superficial viral infections. Br. J. Ophthalmol. 1997, 81:984-988.
50. Tole D.M., McKelvie P.A., Daniell M. Reliability of impression cytology for the diagnosis of ocular surface squamous neoplasia employing the biopore membrane. Br. J. Ophthalmol. 2001, 85:154-158.
51. Tseng S.C.G. Staging of conjunctival metaplasia by impression cytology. Ophthalmology 1985, 92:728-733.
52. Tsubota K., Fujihara T., Saito K., Takeuchi T. Conjunctival epithelium expression of HLA-DR in dry eye patients. Ophthalmologica 1999, 213(1):16-19.
53. Tsubota K., Kajiwara K., Ugajin S., Hasegawa T. Conjunctival brush cytology. Acta Cytol. 1990, 34(2):233-235.
54. Versura P., Profazio V., Schiavi C., Campos E.C. Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and invitro models. Invest. Ophthalmol. Vis. Sci. 2011, 52(8):5488-5496.
55. Wittpenn J.R., Tseng S.C., Sommer A. Detection of early xerophthalmia by impression cytology. Arch. Ophthalmol. 1986, 104(2):237-239.
56. Zhou L., Beuerman R.W., Chan C.M., Zhao S.Z., Li X.R., Yang H., Tong L., Liu S., Stern M.E., Tan D. Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. J. Proteome Res. 2009, 8(11):4889-4905.