Anxiety in major depression and cerebrospinal fluid free gamma-aminobutyric acid

Depression and Anxiety

Volumn 31, Issue 10, 2014, Pages 814-821

  Mann, J John ^a,b   Oquendo, Maria A ^a,b   Watson, Kalycia Trishana ^a,b   Boldrini, Maura ^a,b   Malone, Kevin M ^a,b   Ellis, Steven P ^a,b   Sullivan, Gregory ^a,b   Cooper, Thomas B ^b   Xie, Shan ^b   Currier, Dianne ^c  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Anxiety; Cerebrospinal fluid; Gamma aminobutyric acid; Major depression

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE DERIVATIVE; LORAZEPAM; MONOAMINE DERIVATIVE; 4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; HOMOVANILLIC ACID;

ADULT; ANXIETY DISORDER; ARTICLE; BIPOLAR DISORDER; BROWN GOODWIN LIFE TIME AGGRESSION HISTORY SCORE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EXPOSURE; DSM-IV; FEMALE; HAMILTON SCALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUMBAR PUNCTURE; MAJOR DEPRESSION; MALE; MASS FRAGMENTOGRAPHY; MONOAMINERGIC SYSTEM; MOOD DISORDER; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PATHOPHYSIOLOGY; RESTLESSNESS; SEX DIFFERENCE; SYMPTOMATOLOGY; TENSION; AGE; ANXIETY; CASE CONTROL STUDY; MIDDLE AGED; PSYCHOLOGY; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADULT; AGE FACTORS; ANXIETY; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEPRESSIVE DISORDER, MAJOR; FEMALE; GAMMA-AMINOBUTYRIC ACID; HOMOVANILLIC ACID; HUMANS; HYDROXYINDOLEACETIC ACID; MALE; METHOXYHYDROXYPHENYLGLYCOL; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84914162764     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22278     Document Type: Article

References (64)

1. Petty F, Fulton M, Kramer GL, et al. Evidence for the segregation of a major gene for human plasma GABA levels. Mol Psychiatry 1999;4(6):587-589.
2. Sanacora G, Mason GF, Rothman DL, et al. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry 1999;56(11):1043-1047.
3. Sanacora G, Gueorguieva R, Epperson CN, et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry 2004;61(7): 705-713.
4. Hasler G, Neumeister A, van der Veen JW, et al. Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biol Psychiatry 2005;58(12):969-973.
5. Underwood MD, Kassir SA, Bakalian MJ, et al. Neuron density and serotonin receptor binding in prefrontal cortex in suicide. Int J Neuropsychopharmacol 2012;15(4):435-447.
6. Benes FM, Majocha R, Bird ED, Marotta CA. Increased vertical axon numbers in cingulate cortex of schizophrenics. Arch Gen Psychiatry 1987;44(11):1017-1021.
7. Boldrini M, Santiago AN, Hen R, et al. Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology 2013;38(6):1068-1077.
8. Petty F. GABA and mood disorders: a brief review and hypothesis. J Affect Disord 1995;34(4):275-281.
9. Lloyd KG, Morselli PL, Bartholini G. GABA and affective disorders. Med Biol 1987;65(2-3):159-165.
10. B receptor binding sites in rat frontal cortex. Br J Pharmacol 1993;110(2):724-735.
11. A receptor mRNAs are increased after electroconvulsive shock. Psychopharmacol Bull 1991;27(3):359-363.
12. 3H]-diazepam binding in rat brain following repeated electroconvulsive shock. J Neural Transm 1983;56(1):3-12.
13. Green AR, Sant K, Bowdler JM, Cowen PJ. Further evidence for a relationship between changes in GABA concentration in rat brain and enhanced monoamine-mediated behavioural responses following repeated electroconvulsive shock. Neuropharmacology 1982;21(10):981-984.
14. Cunningham MO, Jones RS. The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro. Neuropharmacology 2000;39(11):2139-2146.
15. Gareri P, Falconi U, De Fazio P, De Sarro G. Conventional and new antidepressant drugs in the elderly. Prog Neurobiol 2000;61(4):353-396.
16. Post RM, Ballenger JC, Hare TA, Bunney WE, Jr. Lack of effect of carbamazepine on gamma-aminobutyric acid in cerebrospinal fluid. Neurology 1980;30(9):1008-1011.
17. Bhagwagar Z, Wylezinska M, Taylor M, et al. Increased brain GABA concentrations following acute administration ofaselective serotonin reuptake inhibitor. Am J Psychiatry 2004;161(2):368-370.
18. Sanacora G, Mason GF, Rothman DL, Krystal JH. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am J Psychiatry 2002;159(4):663-665.
19. Klein DF. Mixed anxiety depression. For and against. Encephale 1993;19(3):493-495.
20. Mountjoy CQ, Roth M. Studies in the relationship between depressive disorders and anxiety states. Part 2. Clinical items. J Affect Disord 1982;4(2):149-161.
21. Roth M, Gurney C, Garside RF, Kerr TA. Studies in the classification of affective disorders. The relationship between anxiety states and depressive illnesses-I. Br J Psychiatr 1972;121: 147-161.
22. Russell GFM, Desilva P. Observations on the relationship between anxiety and depressive symptoms during the course of depressive-illnesses. Br J Clin Pharmacol 1983;15: S147-S153.
23. A receptor subtype is involved? Trends Pharmacol Sci 2001;22(8):402-403.
24. A receptor subunit gene expression. Molecular Psychiatry 2001;6:404-412.
25. A) receptor sub-units and benzodiazepine binding: significance to clinical syndromes and their treatment. Br J Biomed Sci 2001;58:111-121.
26. Nutt DJ. Neurobiological mechanisms in generalized anxiety disorder. J Clin Psychiatry 2001;62(suppl 11):22-27; discussion 28.
27. Jetty PV, Charney DS, Goddard AW. Neurobiology of generalized anxiety disorder. Psychiatr Clin North Am 2001;24(1):75-97.
28. Helmuth L. Neuroscience. A possible target for better benzodiazepines. Science 2000;290(5489):23-25.
29. A receptor subtypes. Nature 1999;401:796-800.
30. Goddard AW, Mason GF, Almai A, et al. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Arch Gen Psychiatry 2001;58(6):556-561.
31. Gerner RH, Fairbanks L, Anderson GM, et al. Csf Neurochemistry in Depressed, Manic, and Schizophrenic-Patients Compared with That of Normal Controls. Am J Psychiatry 1984;141(12):1533-1540.
32. Berrettini WH, Nurnberger JI, Jr., Hare TA, et al. CSF GABA in euthymic manic-depressive patients and controls. Biol Psychiatry 1986;21(8-9):844-846.
33. Roy A, Dejong J, Ferraro T. CSF GABA in depressed patients and normal controls. Psychol Med 1991;21(3):613-618.
34. Hare TA, Wood JH, Manyam BV, et al. Central nervous system γ-aminobutyric acid activity in man. Relationship to age and sex as reflected in CSF. Arch Neurol 1982;39:247-249.
35. McGeer EG, McGeer PL. Aging and neurotransmitter systems. Adv Biochem Psychopharmacol 1980;23:305-314.
36. Perry TL, Hansen S, Schier GM, Halpern B. Isolation and identification of γ-aminobutyryl-cystathionine from human brain and CSF. J Neurochem 1977;29:791-795.
37. Reisine TD, Yamamura HI, Bird ED, et al. Pre- and postsynaptic neurochemical alterations in Alzheimer's disease. Brain Res 1978;159(2):477-481.
38. Brown RP, Stoll PM, Stokes PE, et al. Adrenocortical hyperactivity in depression: effects of agitation, delusions, melancholia, and other illness variables. Psychiatr Res 1987;23:167-178.
39. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
40. Overall JE, Gorham DR. The brief psychiatric rating-scale. Psychological Reports 1962;10(3):799-812.
41. Placidi GP, Oquendo MA, Malone KM, et al. Aggressivity, suicide attempts, and depression: relationship to cerebrospinal fluid monoamine metabolite levels. Biol Psychiatry 2001;50(10):783-791.
42. Struys EA, Guerand WS, ten Brink HJ, Jakobs C. Combined method for the determination of gamma-aminobutyric and beta-alanine in cerebrospinal fluid by stable isotope dilution mass spectrometry. J Chromatogr B Biomed Sci Appl 1999;732(1): 245-249.
43. Goddard AW, Mason GF, Appel M, et al. Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. Am J Psychiatry 2004;161(12):2186-2193.
44. Vaiva G, Thomas P, Ducrocq F, et al. Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder. Biol Psychiatry 2004;55(3):250-254.
45. Rimon R, Lepola U, Jolkkonen J, et al. Cerebrospinal fluid gamma-aminobutyric acid in patients with panic disorder. Biol Psychiatry 1995;38(11):737-741.
46. Gerner RH, Hare TA. CSF GABA innormal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa. Am J Psychiatry 1981;138(8):1098-1101.
47. Roy A, Dejong J, Lamparski D, et al. Depression among Alcoholics - Relationship to Clinical and Cerebrospinal-Fluid Variables. Arch Gen Psychiatry 1991;48(5):428-432.
48. Roy A. Neuropeptides in relation to suicidal behavior in depression. Neuropsychobiology 1993;28(4):184-186.
49. Honig A, Bartlett JR, Bouras N, Bridges PK. Amino acid levels in depression: a preliminary investigation. J Psychiatr Res 1988;22(3):159-164.
50. Berrettini WH, Nurnberger JI, Jr., Hare TA, et al. Reduced plasma and CSF γ-aminobutyric acid in affective illness: Effect of lithium carbonate. Biol Psychiatry 1983;18(2):185-194.
51. Lyness JM, Caine ED, King DA, et al. Psychiatric disorders in older primary care patients. J Gen Intern Med 1999;14(4):249-254.
52. Gallo JJ, Lebowitz BD. The epidemiology of common late-life mental disorders in the community: Themes for the new century[Mental health and aging]. Psychiatric Services 1999;50(9):1158-1166.
53. Gottfries CG. Is there a difference between elderly and younger patients with regard to the symptomatology and aetiology of depression? Int Clin Psychopharmacol 1998;13(Suppl 5): S13-S18.
54. Bohlen P, Huot S, Palfreyman MG. The relationship between GABA concentrations in brain and cerebrospinal fluid. Brain Res 1979;167(2):297-305.
55. Abadie P, Boulenger JP, Benali K, et al. Relationships between trait and state anxiety and the central benzodiazepine receptor: a PET study. Eur J Neurosci 1999;11(4):1470-1478.
56. Sullivan GM, Oquendo MA, Huang YY, Mann JJ. Elevated cere-brospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder. Int J Neuropsychopharmacol 2006;9(5):547-556.
57. Sher L, Oquendo MA, Li S, et al. Higher cerebrospinal fluid homovanillic acid levels in depressed patients with comorbid posttraumatic stress disorder. Eur Neuropsychopharmacol 2005;15(2):203-209.
58. Bonne O, Bain E, Neumeister A, et al. No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder. Am J Psychiatry 2005;162(2):383-385.
59. Sullivan GM, Oquendo MA, Simpson N, et al. Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety. Biol Psychiatry 2005;58(12): 947-954.
60. Frankfurt M, Fuchs E, Wuttke W. Sex differences in gamma-aminobutyric acid and glutamate concentrations in discrete rat brain nuclei. Neurosci Lett 1984;50(1-3):245-250.
61. McCarthy MM, Auger AP, Perrot-Sinal TS. Getting excited about GABA and sex differences in the brain. Trends Neurosci 2002;25(6):307-312.
62. Gold BI, Bowers MB, Jr., Roth RH, Sweeney DW. GABA levels in CSF of patients with psychiatric disorders. Am J Psychiatry 1980;137(3):362-364.
63. Kasa K, Otsuki S, Yamamoto M, et al. Cerebrospinal fluid γ-aminobutyric acid and homovanillic acid in depressive disorders. Biological Psychiatry 1982;17(8):877-883.
64. Roy A, DeJong J, Ferraro T, et al. CSF GABA and neuropeptides in pathological gamblers and normal controls. Psychiatry Res 1989;30(2):137-144.