Evidence for the segregation of a major gene for human plasma GABA levels

Molecular Psychiatry

Volumn 4, Issue 6, 1999, Pages 587-589

  Petty, F ^a,b   Fulton, M ^a   Kramer, G L ^b   Kram, M ^b   Davis, L L ^c   Rush, A J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Familiar transmission; Inhibitory neurotransmitter; Mood disorders; Segregation analysis

Indexed keywords

4 AMINOBUTYRIC ACID; NEUROTRANSMITTER;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE SEGREGATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEGREGATION ANALYSIS;

EID: 0032713540     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000569     Document Type: Article

References (14)

1. 1 Petty F, Kramer GL, Gullion CM, Rush AJ. Low plasma gamma-aminobutyric acid levels in male patients with depression. Biol Psychiatry 1992; 32: 354-363.
2. 2 Petty F, Fulton M, Moeller FG, Kramer G, Wilson L, Fraser K et al. Plasma gamma-aminobutyric acid (GABA) is low in alcoholics. Psychopharmacol Bull 1993; 29: 277-281.
3. 3 Berrettini WH, Nurnberger JI, Scheinin M, Seppala T, Linniola M, Narrow W et al. Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients. Biol Psychiatry 1985; 20: 257-269.
4. 4 Krogsgaardlarsen P, Frolund B, Kristiansen U, Frydenvang K, Ebert B. GABA(A) and GABA(B) receptor agonists, partial agonists, antagonists and modulators: design and therapeutic prospects. Eur J Pharm Sci 1997; 5: 355-384.
5. 5 Emrich HM, Zerssen DV, Kissling W, Moller H-J, Windorfer A. Effect of sodium valproate on mania: the GABA-hypothesis of affective disorders. Arch Psychiatr Nervenkr 1980; 229: 1-16.
6. 6 Petty F, Trivedi MH, Fulton M, Rush AJ. Henzodiazepines as antidepressants: does GABA play a role in depression? Biol Psychiatry 1995; 38: 578-591.
7. 7 Schachter SC. Review of the mechanisms of action of antiepileptic drugs. CNS Drugs 1995; 4: 469-477.
8. 8 Gerner RH, Hare TA. CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa. Am J Psychiatry 1981; 138: 1098-1101.
9. 9 Petty F, Kramer GL, Fulton M, Moeller FG, Rush AJ. Low plasma GABA is a trait-like marker for bipolar illness. Neuropsychopharmacology 1993; 9: 125-132.
10. 10 Petty F, Framer GL, Fulton M, Davis L, Rush AJ. Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression. Biol Psychiatry 1995; 37: 806-810.
11. 11 Coryell W, Winokur G, Keller M, Scheftner W, Endicott J. Alcoholism and primary major depression: a family study approach to co-existing disorders, J Affective Disord 1992; 24: 93-99.
12. 12 Davis LL, Kramer GL, Rush AJ, Petty F. Biological trait markers of depression. In: Panksepp J (ed). Advances in Biological Psychiatry, Vol 2. JAI Press Inc: Greenwich, Connecticut, 1996, pp 115-151.
13. 13 Halbreich U, Petty F, Yonkers K, Kramer GL, Rush AJ, Bibi KW. Low plasma GABA during the late luteal phase of women with premenstrual dysphoric disorder. Am J Psychiatry 1996; 153: 718-720.
14. 14 Pinal CS, Tobin AJ. Uniqueness and redundancy in GABA production. Perspect Develop Neurobiol 1998; 5: 109-118.