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Volumn 16, Issue 8, 2014, Pages 857-866

The serotonin transporter genotype modulates the relationship between early stress and adult suicidality in bipolar disorder

Author keywords

Serotonin; Stress; Suicide

Indexed keywords

SEROTONIN TRANSPORTER;

EID: 84914161970     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/bdi.12250     Document Type: Article
Times cited : (42)

References (49)
  • 1
    • 0038475696 scopus 로고    scopus 로고
    • Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    • Leverich GS, Altshuler LL, Frye MA et al. Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network. J Clin Psychiatry 2003; 64: 506-515.
    • (2003) J Clin Psychiatry , vol.64 , pp. 506-515
    • Leverich, G.S.1    Altshuler, L.L.2    Frye, M.A.3
  • 2
    • 84875026105 scopus 로고    scopus 로고
    • Diagnosis-specific disability pension predicts suicidal behaviour and mortality in young adults: a nationwide prospective cohort study
    • pii: e002286.
    • Jonsson U, Alexanderson K, Kjeldgard L, Westerlund H, Mittendorfer-Rutz E. Diagnosis-specific disability pension predicts suicidal behaviour and mortality in young adults: a nationwide prospective cohort study. BMJ Open 2013; 3: pii: e002286.
    • (2013) BMJ Open , vol.3
    • Jonsson, U.1    Alexanderson, K.2    Kjeldgard, L.3    Westerlund, H.4    Mittendorfer-Rutz, E.5
  • 3
    • 57449086531 scopus 로고    scopus 로고
    • Risk of suicide after suicide attempt according to coexisting psychiatric disorder: Swedish cohort study with long term follow-up
    • Tidemalm D, Langstrom N, Lichtenstein P, Runeson B. Risk of suicide after suicide attempt according to coexisting psychiatric disorder: Swedish cohort study with long term follow-up. BMJ 2008; 337: a2205.
    • (2008) BMJ , vol.337 , pp. a2205
    • Tidemalm, D.1    Langstrom, N.2    Lichtenstein, P.3    Runeson, B.4
  • 4
    • 83755163015 scopus 로고    scopus 로고
    • Genetic and environmental contributions to self-reported thoughts of self-harm and suicide
    • Althoff RR, Hudziak JJ, Willemsen G et al. Genetic and environmental contributions to self-reported thoughts of self-harm and suicide. Am J Med Genet B Neuropsychiatr Genet 2012; 159B: 120-127.
    • (2012) Am J Med Genet B Neuropsychiatr Genet , vol.159 B , pp. 120-127
    • Althoff, R.R.1    Hudziak, J.J.2    Willemsen, G.3
  • 5
    • 0032078822 scopus 로고    scopus 로고
    • Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study
    • Felitti VJ, Anda RF, Nordenberg D et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med 1998; 14: 245-258.
    • (1998) Am J Prev Med , vol.14 , pp. 245-258
    • Felitti, V.J.1    Anda, R.F.2    Nordenberg, D.3
  • 6
    • 42249096306 scopus 로고    scopus 로고
    • Stress, genes and the biology of suicidal behavior
    • Currier D, Mann JJ. Stress, genes and the biology of suicidal behavior. Psychiatr Clin North Am 2008; 31: 247-269.
    • (2008) Psychiatr Clin North Am , vol.31 , pp. 247-269
    • Currier, D.1    Mann, J.J.2
  • 8
    • 85055807041 scopus 로고    scopus 로고
    • Zai CC, de Luca V, Strauss J et al. Genetic factors and suicidal behavior. In: Dwivedi Y ed. The Neurobiological Basis of Suicide. Boca Raton, FL: CRC Press, 2012: Chapter 11. Available from: http://www.ncbi.nlm.nih.gov/books/NBK107191.
  • 9
    • 0142153196 scopus 로고    scopus 로고
    • Neurobiology of suicidal behaviour
    • Mann JJ. Neurobiology of suicidal behaviour. Nat Rev Neurosci 2003; 4: 819-828.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 819-828
    • Mann, J.J.1
  • 10
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    • Lesch KP, Bengel D, Heils A et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
    • (1996) Science , vol.274 , pp. 1527-1531
    • Lesch, K.P.1    Bengel, D.2    Heils, A.3
  • 11
    • 0032974781 scopus 로고    scopus 로고
    • Serotonin transporter genotype and seasonal variation in serotonin function
    • Hanna GL, Cook EH. Serotonin transporter genotype and seasonal variation in serotonin function. Neuropsychopharmacology 1999; 20: 506.
    • (1999) Neuropsychopharmacology , vol.20 , pp. 506
    • Hanna, G.L.1    Cook, E.H.2
  • 12
    • 0031930348 scopus 로고    scopus 로고
    • Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
    • Little KY, McLaughlin DP, Zhang L et al. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 1998; 155: 207-213.
    • (1998) Am J Psychiatry , vol.155 , pp. 207-213
    • Little, K.Y.1    McLaughlin, D.P.2    Zhang, L.3
  • 13
    • 0033525170 scopus 로고    scopus 로고
    • Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets
    • Greenberg BD, Tolliver TJ, Huang SJ et al. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 1999; 88: 83-87.
    • (1999) Am J Med Genet , vol.88 , pp. 83-87
    • Greenberg, B.D.1    Tolliver, T.J.2    Huang, S.J.3
  • 14
    • 0034176712 scopus 로고    scopus 로고
    • A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity
    • Heinz A, Jones DW, Mazzanti C et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 2000; 47: 643-649.
    • (2000) Biol Psychiatry , vol.47 , pp. 643-649
    • Heinz, A.1    Jones, D.W.2    Mazzanti, C.3
  • 15
    • 40949098696 scopus 로고    scopus 로고
    • Lithium overcomes the influence of 5-HTTLPR gene polymorphism on antidepressant response to sleep deprivation
    • Benedetti F, Barbini B, Bernasconi A et al. Lithium overcomes the influence of 5-HTTLPR gene polymorphism on antidepressant response to sleep deprivation. J Clin Psychopharmacol 2008; 28: 249-251.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 249-251
    • Benedetti, F.1    Barbini, B.2    Bernasconi, A.3
  • 16
    • 77951854270 scopus 로고    scopus 로고
    • Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits
    • Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010; 167: 509-527.
    • (2010) Am J Psychiatry , vol.167 , pp. 509-527
    • Caspi, A.1    Hariri, A.R.2    Holmes, A.3    Uher, R.4    Moffitt, T.E.5
  • 17
    • 34548314067 scopus 로고    scopus 로고
    • Long story short: the serotonin transporter in emotion regulation and social cognition
    • Canli T, Lesch KP. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 2007; 10: 1103-1109.
    • (2007) Nat Neurosci , vol.10 , pp. 1103-1109
    • Canli, T.1    Lesch, K.P.2
  • 18
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    • Caspi A, Sugden K, Moffitt TE et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-389.
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1    Sugden, K.2    Moffitt, T.E.3
  • 19
    • 79952033418 scopus 로고    scopus 로고
    • The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation
    • Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 2011; 68: 444-454.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 444-454
    • Karg, K.1    Burmeister, M.2    Shedden, K.3    Sen, S.4
  • 20
    • 2342614896 scopus 로고    scopus 로고
    • Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis
    • Lin PY, Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry 2004; 55: 1023-1030.
    • (2004) Biol Psychiatry , vol.55 , pp. 1023-1030
    • Lin, P.Y.1    Tsai, G.2
  • 21
    • 84880840980 scopus 로고    scopus 로고
    • Positron emission tomography quantification of serotonin transporter in suicide attempters with major depressive disorder
    • Miller JM, Hesselgrave N, Ogden RT et al. Positron emission tomography quantification of serotonin transporter in suicide attempters with major depressive disorder. Biol Psychiatry 2013; 74: 287-295.
    • (2013) Biol Psychiatry , vol.74 , pp. 287-295
    • Miller, J.M.1    Hesselgrave, N.2    Ogden, R.T.3
  • 22
    • 0033838035 scopus 로고    scopus 로고
    • A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide
    • Mann JJ, Huang YY, Underwood MD et al. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 2000; 57: 729-738.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 729-738
    • Mann, J.J.1    Huang, Y.Y.2    Underwood, M.D.3
  • 23
    • 22844433107 scopus 로고    scopus 로고
    • 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    • Pezawas L, Meyer-Lindenberg A, Drabant EM et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828-834.
    • (2005) Nat Neurosci , vol.8 , pp. 828-834
    • Pezawas, L.1    Meyer-Lindenberg, A.2    Drabant, E.M.3
  • 24
    • 56449086132 scopus 로고    scopus 로고
    • Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
    • Frodl T, Koutsouleris N, Bottlender R et al. Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression. Mol Psychiatry 2008; 13: 1093-1101.
    • (2008) Mol Psychiatry , vol.13 , pp. 1093-1101
    • Frodl, T.1    Koutsouleris, N.2    Bottlender, R.3
  • 25
    • 55349093982 scopus 로고    scopus 로고
    • Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression
    • Frodl T, Zill P, Baghai T et al. Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 1003-1007.
    • (2008) Am J Med Genet B Neuropsychiatr Genet , vol.147 B , pp. 1003-1007
    • Frodl, T.1    Zill, P.2    Baghai, T.3
  • 26
    • 79955481926 scopus 로고    scopus 로고
    • Decreased regional gray matter volume in S' allele carriers of the 5-HTTLPR triallelic polymorphism
    • Selvaraj S, Godlewska BR, Norbury R et al. Decreased regional gray matter volume in S' allele carriers of the 5-HTTLPR triallelic polymorphism. Mol Psychiatry 2011; 16: 472-473.
    • (2011) Mol Psychiatry , vol.16 , pp. 472-473
    • Selvaraj, S.1    Godlewska, B.R.2    Norbury, R.3
  • 27
    • 84857709807 scopus 로고    scopus 로고
    • Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum
    • Teicher MH, Anderson CM, Polcari A. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc Natl Acad Sci USA 2012; 109: E563-E572.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. E563-E572
    • Teicher, M.H.1    Anderson, C.M.2    Polcari, A.3
  • 28
    • 79956332660 scopus 로고    scopus 로고
    • Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences
    • Benedetti F, Radaelli D, Poletti S et al. Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences. Psychol Med 2011; 41: 509-519.
    • (2011) Psychol Med , vol.41 , pp. 509-519
    • Benedetti, F.1    Radaelli, D.2    Poletti, S.3
  • 29
    • 78650801756 scopus 로고    scopus 로고
    • Exposure to parental verbal abuse is associated with increased gray matter volume in superior temporal gyrus
    • Tomoda A, Sheu YS, Rabi K et al. Exposure to parental verbal abuse is associated with increased gray matter volume in superior temporal gyrus. Neuroimage 2011; 54 (Suppl. 1): S280-S286.
    • (2011) Neuroimage , vol.54 , pp. S280-S286
    • Tomoda, A.1    Sheu, Y.S.2    Rabi, K.3
  • 30
    • 84861999740 scopus 로고    scopus 로고
    • Cumulative adversity and smaller gray matter volume in medial prefrontal, anterior cingulate, and insula regions
    • Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R. Cumulative adversity and smaller gray matter volume in medial prefrontal, anterior cingulate, and insula regions. Biol Psychiatry 2012; 72: 57-64.
    • (2012) Biol Psychiatry , vol.72 , pp. 57-64
    • Ansell, E.B.1    Rando, K.2    Tuit, K.3    Guarnaccia, J.4    Sinha, R.5
  • 31
    • 77956172590 scopus 로고    scopus 로고
    • Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression
    • Frodl T, Reinhold E, Koutsouleris N, Reiser M, Meisenzahl EM. Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression. J Psychiatr Res 2010; 44: 799-807.
    • (2010) J Psychiatr Res , vol.44 , pp. 799-807
    • Frodl, T.1    Reinhold, E.2    Koutsouleris, N.3    Reiser, M.4    Meisenzahl, E.M.5
  • 32
    • 41249084517 scopus 로고    scopus 로고
    • Stress, sensitive periods and maturational events in adolescent depression
    • Andersen SL, Teicher MH. Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci 2008; 31: 183-191.
    • (2008) Trends Neurosci , vol.31 , pp. 183-191
    • Andersen, S.L.1    Teicher, M.H.2
  • 33
    • 0014118642 scopus 로고
    • The Social Readjustment Rating Scale
    • Holmes TH, Rahe RH. The Social Readjustment Rating Scale. J Psychosom Res 1967; 11: 213-218.
    • (1967) J Psychosom Res , vol.11 , pp. 213-218
    • Holmes, T.H.1    Rahe, R.H.2
  • 34
    • 80054981572 scopus 로고    scopus 로고
    • Opposite effects of suicidality and lithium on gray matter volumes in bipolar depression
    • Benedetti F, Radaelli D, Poletti S et al. Opposite effects of suicidality and lithium on gray matter volumes in bipolar depression. J Affect Disord 2011; 135: 139-147.
    • (2011) J Affect Disord , vol.135 , pp. 139-147
    • Benedetti, F.1    Radaelli, D.2    Poletti, S.3
  • 35
    • 0036154267 scopus 로고    scopus 로고
    • Serotonin transporter promoter genotype and illness recurrence in mood disorders
    • Smeraldi E, Benedetti F, Zanardi R. Serotonin transporter promoter genotype and illness recurrence in mood disorders. Eur Neuropsychopharmacol 2002; 12: 73-75.
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 73-75
    • Smeraldi, E.1    Benedetti, F.2    Zanardi, R.3
  • 36
    • 33646019037 scopus 로고    scopus 로고
    • Statistics: methods and applications. a comprehensive reference for science, industry, and data mining
    • Tulsa, OK: StatSoft
    • Hill T, Lewicki P. Statistics: methods and applications. a comprehensive reference for science, industry, and data mining. Tulsa, OK: StatSoft, 2006: 245-276.
    • (2006) , pp. 245-276
    • Hill, T.1    Lewicki, P.2
  • 37
    • 85030987095 scopus 로고    scopus 로고
    • Dobson AJ. An Introduction to Generalized Linear Models. New York, NY: Chapman & Hall, 1990.
  • 38
    • 85030993976 scopus 로고    scopus 로고
    • McCullagh P, Nelder JA. Generalized Linear Models, 2nd edn. New York, NY: Chapman & Hall, 1989.
  • 39
    • 84947574920 scopus 로고    scopus 로고
    • Agresti A. An Introduction to Categorical Data Analysis. New York, NY: Wiley, 1996.
  • 40
    • 79952012111 scopus 로고    scopus 로고
    • Looking on the bright side of serotonin transporter gene variation
    • Homberg JR, Lesch KP. Looking on the bright side of serotonin transporter gene variation. Biol Psychiatry 2011; 69: 513-519.
    • (2011) Biol Psychiatry , vol.69 , pp. 513-519
    • Homberg, J.R.1    Lesch, K.P.2
  • 41
    • 0141679225 scopus 로고    scopus 로고
    • The long-term course of rapid-cycling bipolar disorder
    • Coryell W, Solomon D, Turvey C et al. The long-term course of rapid-cycling bipolar disorder. Arch Gen Psychiatry 2003; 60: 914-920.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 914-920
    • Coryell, W.1    Solomon, D.2    Turvey, C.3
  • 42
    • 61549098133 scopus 로고    scopus 로고
    • Candidate endophenotypes for genetic studies of suicidal behavior
    • Mann JJ, Arango VA, Avenevoli S et al. Candidate endophenotypes for genetic studies of suicidal behavior. Biol Psychiatry 2009; 65: 556-563.
    • (2009) Biol Psychiatry , vol.65 , pp. 556-563
    • Mann, J.J.1    Arango, V.A.2    Avenevoli, S.3
  • 43
    • 33846882129 scopus 로고    scopus 로고
    • Neural and genetic correlates of antidepressant response to sleep deprivation - a functional magnetic resonance imaging study of moral valence decision, in bipolar depression
    • Benedetti F, Bernasconi A, Blasi V et al. Neural and genetic correlates of antidepressant response to sleep deprivation - a functional magnetic resonance imaging study of moral valence decision, in bipolar depression. Arch Gen Psychiatry 2007; 64: 179-187.
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 179-187
    • Benedetti, F.1    Bernasconi, A.2    Blasi, V.3
  • 44
    • 69249205428 scopus 로고    scopus 로고
    • Cognitive learning is associated with gray matter changes in healthy human individuals: a tensor-based morphometry study
    • Ceccarelli A, Rocca MA, Pagani E et al. Cognitive learning is associated with gray matter changes in healthy human individuals: a tensor-based morphometry study. Neuroimage 2009; 48: 585-589.
    • (2009) Neuroimage , vol.48 , pp. 585-589
    • Ceccarelli, A.1    Rocca, M.A.2    Pagani, E.3
  • 45
    • 84980697661 scopus 로고    scopus 로고
    • Adverse childhood experiences influence white matter microstructure in patients with bipolar disorder
    • Benedetti F, Bollettini I, Radaelli D et al. Adverse childhood experiences influence white matter microstructure in patients with bipolar disorder. Psychol Med 2014; 44: 3069-3082.
    • (2014) Psychol Med , vol.44 , pp. 3069-3082
    • Benedetti, F.1    Bollettini, I.2    Radaelli, D.3
  • 46
    • 84906988149 scopus 로고    scopus 로고
    • 5-HTTLPR Polymorphism modulates neural mechanisms of negative self-reflection
    • Ma Y, Li B, Wang C et al. 5-HTTLPR Polymorphism modulates neural mechanisms of negative self-reflection. Cereb Cortex 2013; 24: 2421-2429.
    • (2013) Cereb Cortex , vol.24 , pp. 2421-2429
    • Ma, Y.1    Li, B.2    Wang, C.3
  • 47
    • 77955143338 scopus 로고    scopus 로고
    • Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques
    • Kinnally EL, Capitanio JP, Leibel R et al. Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques. Genes Brain Behav 2010; 9: 575-582.
    • (2010) Genes Brain Behav , vol.9 , pp. 575-582
    • Kinnally, E.L.1    Capitanio, J.P.2    Leibel, R.3
  • 48
    • 59849095464 scopus 로고    scopus 로고
    • The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population
    • Zhang K, Xu Q, Xu Y et al. The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population. J Affect Disord 2009; 114: 224-231.
    • (2009) J Affect Disord , vol.114 , pp. 224-231
    • Zhang, K.1    Xu, Q.2    Xu, Y.3
  • 49
    • 68849090814 scopus 로고    scopus 로고
    • Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults
    • Laucht M, Treutlein J, Blomeyer D et al. Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults. Int J Neuropsychopharmacol 2009; 12: 737-747.
    • (2009) Int J Neuropsychopharmacol , vol.12 , pp. 737-747
    • Laucht, M.1    Treutlein, J.2    Blomeyer, D.3


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