Untargeted mass spectrometry-based metabolomic profiling of pleural effusions: Fatty acids as novel cancer biomarkers for malignant pleural effusions

Journal of Proteome Research

Volumn 13, Issue 9, 2014, Pages 4040-4046

  Lam, Ching Wan ^a   Law, Chun Yiu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

fatty acids; mass spectrometry; Metabolomic profiling; pleural effusions

Indexed keywords

CERAMIDE; FATTY ACID; FATTY ACID SYNTHASE; OLEIC ACID; TUMOR MARKER;

AGED; ARTICLE; CANCER CELL; CANCER DIAGNOSIS; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; DATA BASE; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; LUNG TUBERCULOSIS; MALE; MALIGNANT PLEURA EFFUSION; METABOLOME; METABOLOMICS; PHENOTYPE; PROTEIN EXPRESSION; RECEIVER OPERATING CHARACTERISTIC; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; ADULT; CHEMISTRY; LUNG TUMOR; METABOLISM; MIDDLE AGED; PLEURAL EFFUSION, MALIGNANT; PROCEDURES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; FATTY ACIDS; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; METABOLOMICS; MIDDLE AGED; PLEURAL EFFUSION, MALIGNANT; TANDEM MASS SPECTROMETRY; TUMOR MARKERS, BIOLOGICAL;

EID: 84914141686     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr5003774     Document Type: Article

References (23)

1. Stieber, P.; Hatz, R.; Holdenrieder, S.; Molina, R.; Nap, M.; Pawel, J.; Schalhorn, A.; Schneider, J.; Yamaguchi, K. National Academy of Clinical Biochemistry Guidelines for the Use of Tumor Markers in Lung Cancer. In NACB: Practice Guidelines and Recommendations for Use of Tumor Markers in the Lung Cancer (Section 3p). http://www.aacc.org/Search/Pages/results.aspx/Results.aspx?k=lung%20cancer%20markers# (accessed on Mar 1, 2014).
2. Marel, M.; Zrustova, M.; Stasny, B.; Light, R. W. The incidence of pleural effusion in a well-defined region. Epidemiologic study in central bohemia Chest 1993, 104 (5) 1486-9
3. Valdes, L.; Alvarez, D.; Valle, J. M.; Pose, A.; San Jose, E. The etiology of pleural effusions in an area with high incidence of tuberculosis Chest 1996, 109 (1) 158-62
4. American Thoracic Society Management of malignant pleural effusions. Am. J. Respir. Crit. Care. Med. 2000, 162 (5) 1987-2001
5. Maji, A.; Maikap, M. K.; Jash, D.; Saha, K.; Kundu, A.; Saha, D.; Banerjee, S.; Patra, A. Role of common investigations in aetiological evaluation of exudative pleural effusions J. Clin. Diagn. Res. 2013, 7 (10) 2223-6
6. Shitrit, D.; Zingerman, B.; Shitrit, A. B.; Shlomi, D.; Kramer, M. R. Diagnostic value of CYFRA 21-1, CEA, CA 19-9, CA 15-3, and CA 125 assays in pleural effusions: Analysis of 116 cases and review of the literature Oncologist 2005, 10 (7) 501-7
7. San Jose, M. E.; Alvarez, D.; Valdes, L.; Sarandeses, A.; Valle, J. M.; Penela, P. Utility of tumour markers in the diagnosis of neoplastic pleural effusion Clin. Chim. Acta 1997, 265 (2) 193-205
8. Nicholson, J. K.; Lindon, J. C.; Holmes, E. "Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 1999, 29 (11) 1181-9
9. Kinross, J. M.; Holmes, E.; Darzi, A. W.; Nicholson, J. K. Metabolic phenotyping for monitoring surgical patients Lancet 2011, 377 (9780) 1817-9
10. Xia, J.; Broadhurst, D. I.; Wilson, M.; Wishart, D. S. Translational biomarker discovery in clinical metabolomics: An introductory tutorial Metabolomics 2013, 9 (2) 280-99
11. Chadeau-Hyam, M.; Ebbels, T. M.; Brown, I. J.; Chan, Q.; Stamler, J.; Huang, C. C.; Daviglus, M. L.; Ueshima, H.; Zhao, L.; Holmes, E.; Nicholson, J. K.; Elliott, P.; De Iorio, M. Metabolic profiling and the metabolome-wide association study: Significance level for biomarker identification J. Proteome Res. 2010, 9 (9) 4620-7
12. Wishart, D. S.; Jewison, T.; Guo, A. C.; Wilson, M.; Knox, C.; Liu, Y.; Djoumbou, Y.; Mandal, R.; Aziat, F.; Dong, E.; Bouatra, S.; Sinelnikov, I.; Arndt, D.; Xia, J.; Liu, P.; Yallou, F.; Bjorndahl, T.; Perez-Pineiro, R.; Eisner, R.; Allen, F.; Neveu, V.; Greiner, R.; Scalbert, A. HMDB 3.0: The human metabolome database in 2013 Nucleic Acids Res. 2013, 41, D801-7
13. Obuchowski, N. A.; Lieber, M. L.; Wians, F. H., Jr. ROC curves in clinical chemistry: Uses, misuses, and possible solutions Clin. Chem. 2004, 50 (7) 1118-25
14. Zweig, M. H.; Campbell, G. Receiver-operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine Clin. Chem. 1993, 39 (4) 561-77
15. Soreide, K. Receiver-operating characteristic curve analysis in diagnostic, prognostic and predictive biomarker research J. Clin. Pathol. 2009, 62 (1) 1-5
16. Light, R. W.; Macgregor, M. I.; Luchsinger, P. C.; Ball, W. C., Jr. Pleural effusions: The diagnostic separation of transudates and exudates Ann. Int. Med. 1972, 77 (4) 507-13
17. Light, R. W. Clinical practice. Pleural effusion N. Engl. J. Med. 2002, 346 (25) 1971-7
18. Hooper, C.; Lee, Y. C.; Maskell, N. BTS Pleural Guideline Group; Investigation of a Unilateral Pleural Effusion in Adults: British Thoracic Society Pleural Disease Guideline 2010 Thorax 2010, 65, 4-17
19. Menendez, J. A.; Lupu, R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis Nat. Rev. Cancer 2007, 7 (10) 763-77
20. Swinnen, J. V.; Brusselmans, K.; Verhoeven, G. Increased lipogenesis in cancer cells: new players, novel targets Curr. Opin. Clin. Nutr. Metab. Care 2006, 9 (4) 358-65
21. Visca, P.; Sebastiani, V.; Botti, C.; Diodoro, M. G.; Lasagni, R. P.; Romagnoli, F.; Brenna, A.; De Joannon, B. C.; Donnorso, R. P.; Lombardi, G.; Alo, P. L. Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma Anticancer Res. 2004, 24 (6) 4169-73
22. Flavin, R.; Peluso, S.; Nguyen, P. L.; Loda, M. Fatty acid synthase as a potential therapeutic target in cancer Future Oncol. 2010, 6 (4) 551-62
23. Agostini, M.; Almeida, L. Y.; Bastos, D. C.; Ortega, R. M.; Moreira, F. S.; Seguin, F.; Zecchin, K. G.; Raposo, H. F.; Oliveira, H. C.; Amoêdo, N. D.; Salo, T.; Coletta, R. D.; Graner, E. The fatty acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas Mol. Cancer Ther. 2014 Mar, 13 (3) 585-95