Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: Evidence for protective role of CYP1A1 against oxidative stress

Toxicological Sciences

Volumn 141, Issue 1, 2014, Pages 68-77

  Lingappan, Krithika ^a   Jiang, Weiwu ^a   Wang, Lihua ^a   Wang, Gangduo ^b   Couroucli, Xanthi I ^a   Shivanna, Binoy ^a   Welty, Stephen E ^a   Barrios, Roberto ^a   Khan, M Firoze ^b   Nebert, Daniel W ^c   Roberts, L Jackson ^d   Moorthy, Bhagavatula ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CYP1A1 protein (or enzyme); Hyperoxia; Lung injury; Mouse Cyp1a1 gene

Indexed keywords

CYTOCHROME P450 1A; CYTOCHROME P450 1A1; ENZYME; FURAN DERIVATIVE; ISOFURAN; ISOPROSTANE DERIVATIVE; LIPID HYDROPEROXIDE; MESSENGER RNA; OXYGEN; PROTEIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT CYTOCHROME P450 1A1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMBIENT AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; BODY WEIGHT; CONTROLLED STUDY; ENZYME BLOOD LEVEL; GENE EXPRESSION; GENE FUNCTION; HYPEROXIA; HYPOXIA; IN VIVO STUDY; INFLAMMATION; LUNG INJURY; LUNG WEIGHT; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; WILD TYPE; ACUTE LUNG INJURY; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; LIPID PEROXIDATION; LUNG; ORGAN SIZE; PATHOLOGY; WESTERN BLOTTING;

MUS;

ACUTE LUNG INJURY; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; CYTOCHROME P-450 CYP1A1; HYPEROXIA; LIPID PEROXIDATION; LUNG; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; ORGAN SIZE; OXIDATIVE STRESS;

EID: 84913617146     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu106     Document Type: Article

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