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Volumn 22, Issue 24, 2014, Pages 6846-6856
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Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of α3β4 nicotinic acetylcholine receptor
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Author keywords
Dextromethorphan; Nicotinic acetylcholine receptors; Non competitive inhibitors; 3 4 nicotinic acetylcholine receptor
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Indexed keywords
(9 ALPHA,13 ALPHA,14 ALPHA) 17 (2 CYANOETHYL) 3 METHOXYMORPHINAN HYDROCHLORIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 (2 OXOBUTYL) 3 METHOXYMORPHINAN HYDROBROMIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 (3 CYANOETHYL) 3 METHOXYMORPHINAN HYDROBROMIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 (3 CYANOPROPYL) 3 METHOXYMORPHINAN HYDROBROMIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 (3 OXOBUTYL) 3 METHOXYMORPHINAN HYDROBROMIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 AMIDOMETHYL 3 METHOXYMORPHINAN HYDROBROMIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 CYANOMETHYL 3 METHOXYMORPHINAN HYDROBROMIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 [(1,3 DIOXOLAN 2 YL)METHYL] 3 METHOXYMORPHINAN HYDROBROMIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 [(4,5 DIHYDRO 1H IMIDAZOL 2 YL)METHYL] 3 METHOXYMORPHINAN HYDROBROMIDE;
(9 ALPHA,13 ALPHA,14 ALPHA) 17 [2 (1,3 DIOXOLAN 2 YL)ETHYL] 3 METHOXYMORPHINAN;
DEXTROMETHORPHAN;
DEXTROMETHORPHAN DERIVATIVE;
NICOTINE;
NICOTINIC RECEPTOR;
NICOTINIC RECEPTOR ALPHA3BETA4;
NICOTINIC RECEPTOR BLOCKING AGENT;
UNCLASSIFIED DRUG;
1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE;
LIGAND;
LIPID BILAYER;
PHOSPHATIDYLCHOLINE;
PROTEIN BINDING;
AFFINITY CHROMATOGRAPHY;
ALKYLATION;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ARTICLE;
CONDITIONING;
CONTROLLED STUDY;
DEMETHYLATION;
DRUG SYNTHESIS;
HYDROPHOBICITY;
IN VITRO STUDY;
IN VIVO STUDY;
MALE;
MOLECULAR DYNAMICS;
MOLECULAR MODEL;
MOUSE;
NONHUMAN;
PATCH CLAMP TECHNIQUE;
RAT;
SEQUENCE HOMOLOGY;
ANIMAL;
BINDING SITE;
CELL LINE;
CHEMISTRY;
DRUG EFFECTS;
LIPID BILAYER;
METABOLISM;
MOLECULAR DOCKING;
MOTOR ACTIVITY;
PROTEIN TERTIARY STRUCTURE;
SYNTHESIS;
WISTAR RAT;
ANIMALS;
BINDING SITES;
CELL LINE;
DEXTROMETHORPHAN;
LIGANDS;
LIPID BILAYERS;
MALE;
MOLECULAR DOCKING SIMULATION;
MOTOR ACTIVITY;
NICOTINIC ANTAGONISTS;
PATCH-CLAMP TECHNIQUES;
PHOSPHATIDYLCHOLINES;
PROTEIN BINDING;
PROTEIN STRUCTURE, TERTIARY;
RATS;
RATS, WISTAR;
RECEPTORS, NICOTINIC;
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EID: 84913603586
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2014.10.036 Document Type: Article |
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Times cited : (6)
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References (42)
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