Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at the nucleus accumbens

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 368, Issue 5, 2003, Pages 386-392

  Huang, Eagle Y K ^a   Liu, Te Chen ^a   Tao, Pao Luh ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Conditioned place preference; Dependence; Dextromethorphan; Locomotor activity; Mesolimbic pathway; Microdialysis; Morphine; Nucleus accumbens

Indexed keywords

DEXTROMETHORPHAN; DOPAMINE; MORPHINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; BEHAVIOR; CHEMICAL ANALYSIS; CONTROLLED STUDY; DOPAMINE METABOLISM; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; DRUG DEPENDENCE; DRUG EFFECT; DRUG TOLERANCE; EXTRACELLULAR SPACE; LIMBIC CORTEX; LOCOMOTION; MALE; MENTAL DISEASE; METABOLITE; MICRODIALYSIS; MORPHINE ADDICTION; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PSYCHIC DEPENDENCE; RAT; REWARD; SENSITIZATION;

3,4-DIHYDROXYPHENYLACETIC ACID; ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONDITIONING, OPERANT; DEXTROMETHORPHAN; DOPAMINE; DRUG SYNERGISM; MALE; MICRODIALYSIS; MORPHINE; MOTOR ACTIVITY; NARCOTICS; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; REWARD; TIME FACTORS;

EID: 0345376225     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0803-7     Document Type: Article

References (57)

1. Anderson ST, Curlewis JD (1998) PACAP stimulates dopamine neuronal activity in the medial basal hypothalamus and inhibits prolactin. Brain Res 790:343-346
2. Babbini M, Davis WM (1972) Time-dose relationships for locomotor activity effects of morphine after acute or repeated treatment. Br J Pharmacol 46:213-224
3. Bals-Kubik R, Ableitner A, Herz A, Shippenberg TS (1993) Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. J Pharmacol Exp Ther 264:489-495
4. Bem JL, Peck R (1992) Dextromethorphan. An overview of safety issues. Drug Saf 7:190-199
5. Bisaga A, Sikora J, Kostowski W (1993) The effect of drugs interacting with serotonergic 5HT3 and 5HT4 receptors on morphine place conditioning. Pol J Pharmacol 45:513-519
6. Bozarth MA (1987) Neuroanatomical boundaries of the reward-relevant opiate-receptor field in the ventral tegmental area as mapped by the conditioned place preference method in rats. Brain Res 414:77-84
7. Brady LS, Holtzman SG (1981) Locomotor activity in morphine-dependent and post-dependent rats. Pharmacol Biochem Behav 14:361-370
8. Carboni E, Acquas E, Leone P, Di Chiara G (1989) 5HT3 receptor antagonists block morphine- and nicotine- but not amphetamine-induced reward. Psychopharmacology 97:175-178
9. Chen JC, Liang KW, Huang YK, Liang CS, Chiang YC (2001) Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine. Life Sci 68:973-983
10. Church J, Sawyer D, McLarnon JG (1994) Interactions of dextromethorphan with the N-methyl-D-aspartate receptor-channel complex: single channel recordings. Brain Res 666:189-194
11. Del Pozo E, Barrios M, Baeyens JM (1996) The NMDA receptor antagonist dizocilpine (MK-801) stereoselectively inhibits morphine-induced place preference conditioning in mice. Psychopharmacology (Berl) 125:209-213
12. Ebert B, Thorkildsen C, Andersen S, Christrup LL, Hjeds H (1998) Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists. Biochem Pharmacol 56:553-559
13. Farzin D (1999) Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice. Eur J Pharmacol 377:35-42
14. Franklin PH, Murray TF (1992) High affinity [3H]dextrorphan binding in rat brain is localized to a noncompetitive antagonist site of the activated N-methyl-D-aspartate receptor-cation channel. Mol Pharmacol 41:134-146
15. Glick SD, Maisonneuve IM, Dickinson HA, Kitchen BA (2001) Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats. Eur J Pharmacol 422:87-90
16. Glick SD, Maisonneuve IM, Kitchen BA (2002a) Modulation of nicotine self-administration in rats by combination therapy with agents blocking alpha 3 beta 4 nicotinic receptors. Eur J Pharmacol 448:185-191
17. Glick SD, Maisonneuve IM, Kitchen BA, Heck MW (2002b) Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration. Eur J Pharmacol 438:99-105
18. Gonzalez P, Cabello P, Germany A, Norris B, Contreras E (1997) Decrease of tolerance to, and physical dependence on morphine by, glutamate receptor antagonists. Eur J Pharmacol 332:257-262
19. Gruss M, Bredenkotter M, Braun K (1999) N-methyl-D-aspartate receptor-mediated modulation of monoaminergic metabolites and amino acids in the chick forebrain: an in vivo microdialysis and electrophysiology study. J Neurobiol 40:116-135
20. Hernandez SC, Bertolino M, Xiao Y, Pringle KE, Caruso FS, Kellar KJ (2000) Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors. J Pharmacol Exp Ther 293:962-967
21. Higgins GA, Joharchi N, Nguyen P, Sellers EM (1992) Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning. Psychopharmacology 106:315-320
22. Joyce EM, Iversen SD (1979) The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat. Neurosci Lett 14:207-212
23. Jun JH, Schindler CW (2000) Dextromethorphan alters methamphetamine self-administration in the rat. Pharmacol Biochem Behav 67:405-409
24. Kalivas PW, Duffy P (1987) Sensitization to repeated morphine injection in the rat: possible involvement of A10 dopamine neurons. J Pharmacol Exp Ther 241:204-212
25. Kim HS, Jang CG, Park WK (1996) Inhibition by MK-801 of morphine-induced conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice. Pharmacol Biochem Behav 55:11-17
26. Klein M, Musacchio JM (1989) High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents. J Pharmacol Exp Ther 251:207-215
27. Leone P, Pocock D, Wise RA (1991) Morphine-dopamine interaction: ventral tegmental morphine increases nucleus accumbens dopamine release. Pharmacol Biochem Behav 39:469-472
28. Luo S, Meier AH, Cincotta AH (1998) Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters. Neuroendocrinology 68:1-10
29. Mao J, Price DD, Caruso FS, Mayer DJ (1996) Oral administration of dextromethorphan prevents the development of morphine tolerance and dependence in rats. Pain 67:361-368
30. Mucha RF, Iversen SD (1984) Reinforcing properties of morphine and naloxone revealed by conditioned place preferences: a procedural examination. Psychopharmacology 82:241-247
31. Mucha RF, Herz A (1986) Preference conditioning produced by opioid active and inactive isomers of levorphanol and morphine in rat. Life Sci 38:241-249
32. Mucha RF, van der Kooy D, O'Shaughnessy M, Bucenieks P (1982) Drug reinforcement studied by the use of place conditioning in rat. Brain Res 243:91-105
33. Murray TF, Leid ME (1984) Interaction of dextrorotatory opioids with phencyclidine recognition sites in rat brain membranes. Life Sci 34:1899-1911
34. Nomikos GG, Spyraki C (1988) Effects of ritanserin on the rewarding properties of d-amphetamine, morphine and diazepam revealed by conditioned place preference in rats. Pharmacol Biochem Behav 30:853-858
35. Olmstead MC, Franklin KB (1997) The development of a conditioned place preference to morphine: effects of microinjections into various CNS sites. Behav Neurosci 111:1324-1334
36. Phillips AG, LePiane FG (1980) Reinforcing effects of morphine microinjection into the ventral tegmental area. Pharmacol Biochem Behav 12:965-968
37. Pontieri FE, Tanda G, Di Chiara G (1995) Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proc Natl Acad Sci U S A 92:12304-12308
38. Popik P, Danysz W ( 1997) Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by N-methyl-D-aspartate receptor antagonist, memantine. J Pharmacol Exp Ther 280:854-865
39. Pulvirenti L, Balducci C, Koob GF (1997) Dextromethorphan reduces intravenous cocaine self-administration in the rat. Eur J Pharmacol 321:279-283
40. Rada P, Mark GP, Pothos E, Hoebel BG (1991) Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats. Neuropharmacology 30:1133-1136
41. Robinson TE, Becker JB (1986) Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res 396:157-198
42. Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247-291
43. Segal DS, Kuczenski R (1992a) In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment. Brain Res 571:330-337
44. Segal DS, Kuczenski R (1992b) Repeated cocaine administration induces behavioral sensitization and corresponding decreased extracellular dopamine responses in caudate and accumbens. Brain Res 577:351-355
45. Spyraki C, Nomikos GG, Galanopoulou P, Daifotis Z (1988) Drug-induced place preference in rats with 5,7-dihydroxytryptamine lesions of the nucleus accumbens. Behav Brain Res 29:127-134
46. Steinmiller CL, Maisonneuve IM, Click SD (2003) Effects of dextromethorphan on dopamine release in the nucleus accumbens: Interactions with morphine. Pharmacol Biochem Behav 74:803-810
47. Tao PL, Yeh GC, Su CH, Wu YH (2001) Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring. Life Sci 69:2439-2450
48. Tiseo PJ, Cheng J, Pasternak GW, Inturrisi CE (1994) Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes. J Pharmacol Exp Ther 268:195-201
49. Tokuyama S, Wakabayashi H, Ho IK (1996) Direct evidence for a role of glutamate in the expression of the opioid withdrawal syndrome. Eur J Pharmacol 295:123-129
50. Trujillo KA, Akil H (1991) Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251:85-87
51. Tzschentke TM (1998) Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 56:613-672
52. Tzschentke TM, Schmidt WJ (1995) N-methyl-D-aspartic acid-receptor antagonists block morphine-induced conditioned place preference in rats. Neurosci Lett 193:37-40
53. Tzschentke TM, Schmidt WJ (1997) Interactions of MK-801 and GYKI 52466 with morphine and amphetamine in place preference conditioning and behavioural sensitization. Behav Brain Res 84:99-107
54. Vezina P, Stewart J (1984) Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTA. Pharmacol Biochem Behav 20:925-934
55. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469-492
56. Wu D, Otton SV, Kalow W, Sellers EM (1995) Effects of route of administration on dextromethorphan pharmacokinetics and behavioral response in the rat. J Pharmacol Exp Ther 274:1431-1437
57. Yeh GC, Tao PL, Chen JY, Lai MC, Gao FS, Hu CL (2002) Dextromethorphan attenuates morphine withdrawal syndrome in neonatal rats passively exposed to morphine. Eur J Pharmacol 453:197-202