4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 24, 2014, Pages 6945-6952

  Sitaram, ^a   Ceruso, Mariangela ^b   Khloya, Poonam ^a   Supuran, Claudiu T ^b   Sharma, Pawan K ^a  

^a KURUKSHETRA UNIVERSITY   (India)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

6 Aminosulfonylbenzothiazole; Carbonic anhydrase isoforms I, II, IX, XII Acetazolamide; Pyrazoles

Indexed keywords

1 [6 (AMINOSULFONYL) 1,3 BENZOTHIAZOL 2 YL] 3 (4 CHLOROPHENYL) 1H PYRAZOLE 4 CARBOXYLIC ACID; 1 [6 (AMINOSULFONYL) 1,3 BENZOTHIAZOL 2 YL] 3 (4 FLUOROPHENYL) 1H PYRAZOLE 4 CARBOXYLIC ACID; 1 [6 (AMINOSULFONYL) 1,3 BENZOTHIAZOL 2 YL] 3 (4 METHOXYPHENYL) 1H PYRAZOLE 4 CARBOXYLIC ACID; 1 [6 (AMINOSULFONYL) 1,3 BENZOTHIAZOL 2 YL] 3 (4 METHYLPHENYL) 1H PYRAZOLE 4 CARBOXYLIC ACID; 1 [6 (AMINOSULFONYL) 1,3 BENZOTHIAZOL 2 YL] 3 (4 NITROPHENYL) 1H PYRAZOLE 4 CARBOXYLIC ACID; 1 [6 (AMINOSULFONYL) 1,3 BENZOTHIAZOL 2 YL] 3 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID; 1,3 DIARYLPYRAZOLE DERIVATIVE; 2 (4 CYANO3 PHENYL 1H PYRAZOL 1 YL) 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 (4 FORMYL 3 PHENYL 1H PYRAZOL 1 YL) 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [3 (4 CHLOROPHENYL) 4 CYANO 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [3 (4 CHLOROPHENYL) 4 FORMYL 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [3 (4 FLUOROPHENYL) 4 FORMYL 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [4 CYANO 3 (4 FLUOROPHENYL) 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [4 CYANO 3 (4 METHOXYPHENYL) 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [4 CYANO 3 (4 METHYLPHENYL) 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [4 CYANO 3 (4 NITROPHENYL) 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [4 FORMYL 3 (4 METHOXYPHENYL) 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [4 FORMYL 3 (4 METHYLPHENYL) 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [4 FORMYL 3 (4 NITROPHENYL) 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 2 [4 [(HYDROXYIMINO)METHYL] 3 PHENYL 1H PYRAZOL 1 YL] 1,3 BENZOTHIAZOLE 6 SULFONAMIDE; 6 AMINOSULFONYLBENZOTHIAZOLE; ACETAZOLAMIDE; BENZOTHIAZOLE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; BENZOTHIAZOLE DERIVATIVE; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; PROTEIN BINDING; TUMOR ANTIGEN;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; METABOLISM; SYNTHESIS;

ANTIGENS, NEOPLASM; BENZOTHIAZOLES; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; HUMANS; PROTEIN BINDING; PYRAZOLES;

EID: 84913582362     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.10.018     Document Type: Article

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