Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures

Epilepsy Research

Volumn 108, Issue 10, 2014, Pages 1719-1727

  Klein, Sabine ^a,b   Bankstahl, Marion ^a,b   Gramer, Martina ^a,b   Hausknecht, Maria ^a,b   Löscher, Wolfgang ^a,b  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

Benzodiazepines; Epilepsy; GABA receptors; HPLC, high performance liquid chromatography; Kainate; Pharmacoresistance

Indexed keywords

ALCOHOL; DIAZEPAM; KAINIC ACID; NORDAZEPAM; OXAZEPAM; TEMAZEPAM; ANTICONVULSIVE AGENT; SOLVENT; WATER;

ALCOHOL BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DISEASE CONTROL; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; EMULSION; EPILEPTIC STATE; FEMALE; FOCAL EPILEPSY; MOUSE; MOUSE MODEL; NONHUMAN; TEMPORAL LOBE EPILEPSY; ANIMAL; BLOOD; BRAIN; CHEMISTRY; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; DRUG FORMULATION; DRUG POTENTIATION; ELECTROENCEPHALOGRAPHY; EPILEPSY, TEMPORAL LOBE; PATHOPHYSIOLOGY; SEIZURES;

ANIMALS; ANTICONVULSANTS; BRAIN; DIAZEPAM; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; DRUG SYNERGISM; ELECTROENCEPHALOGRAPHY; EPILEPSY, TEMPORAL LOBE; ETHANOL; FEMALE; KAINIC ACID; MICE; NORDAZEPAM; OXAZEPAM; SEIZURES; SOLVENTS; TEMAZEPAM; WATER;

EID: 84913580442     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2014.10.002     Document Type: Article

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