A toxicological review of the propylene glycols

Critical Reviews in Toxicology

Volumn 43, Issue 4, 2013, Pages 363-390

  Fowles, Jeff R ^a   Banton, Marcy I ^b   Pottenger, Lynn H ^c  

^a Tox Logic Consulting LLC   (United States)

^b LyondellBasell   (United States)

^c DOW CHEMICAL COMPANY   (United States)

Author keywords

Dipropylene glycol; Monopropylene glycol; Polypropylene glycol; Toxicology; Tripropylene glycol

Indexed keywords

ACETYLSALICYLIC ACID; ADHESIVE AGENT; ALLERGEN; ANTIOXIDANT; COSMETIC; DETERGENT; DIPROPYLENE GLYCOL; DYE; EMULSIFYING AGENT; ENZYME; FERTILIZER; FILLER; FOOD ADDITIVE; FRAGRANCE; HEMOGLOBIN; INK; LUBRICATING AGENT; MONOPROPYLENE GLYCOL; OLIGOMER; PAINT; PERFUME; PLASTICIZER; POLYESTER; POLYPROPYLENE GLYCOL; PRESERVATIVE; PROPANEDIOL DERIVATIVE; SOAP; STABILIZING AGENT; SWEETENING AGENT; TRIPROPYLENE GLYCOL; UNCLASSIFIED DRUG; WAX;

ACUTE TOXICITY; ANEMIA; ASTHMA; CARCINOGENICITY; CHRONIC TOXICITY; CLAY; CLEANING; DEHYDRATION; DEVELOPMENTAL TOXICITY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PURITY; DRUG SAFETY; DRUG SENSITIZATION; DRUG USE; ECZEMA; EYE IRRITATION; GENOTOXICITY; HEALTH HAZARD; HEAT TRANSFER; HEMOLYSIS; HUMAN; KETOACIDOSIS; LEATHER INDUSTRY; MAXIMUM TOLERATED DOSE; METABOLIC ACIDOSIS; MINING; MYOPATHY; NEUROPATHY; NONHUMAN; OCCUPATIONAL DISEASE; PLANT PRODUCT; PROCESSING; REPEATED DRUG DOSE; REPRODUCTIVE TOXICITY; REVIEW; RHINITIS; SEIZURE; SENSITIZATION; SKIN IRRITATION; SKIN MANIFESTATION; TERATOLOGY; TOBACCO; WATER TREATMENT;

ANIMALS; CATS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; GUIDELINES AS TOPIC; HUMANS; OCCUPATIONAL EXPOSURE; PROPYLENE GLYCOLS; RISK; SPECIES SPECIFICITY; TOXICITY TESTS;

EID: 84877630974     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2013.792328     Document Type: Review

References (109)

1. ACC PO/PG Panel. (2001). Propylene glycol information update: propylene glycol in cats. Available from: http://msdssearch.dow.-com/ PublishedLiteratureDOWCOM/dh-0046/0901b80380046c77.pdf?filepath1/ 4propyleneglycol/pdfs/noreg/117-01660.pdf&fromPage1/4GetDoc [last accessed Jun 2012].
2. American Industrial Hygiene Association (AIHA). (2011). ERPG/WEEL Handbook. Available from: http://www.aiha.org/insideaiha/Guideline Development/weel/Documents/2011%20WEEL%20Values.pdf [last accessed 15 Aug 2012].
3. Al-Jasser M, Mebuke N, deGannes GC. (2011). Propylene glycol: an often unrecognized cause of allergic contact dermatitis in patients using topical corticosteroids. Skin Therapy Lett, 16, 5-7.
4. American Chemistry Council. (2001). Information update for propylene glycol. propylene glycol panel. Available from: http://msdssearch. dow.com/PublishedLiteratureDOWCOM/dh-0046/0901b80380046c71. pdf?filepath1/ 4propyleneglycol/pdfs/noreg/117-01662.pdf&fromPage1/4 GetDoc [last accessed 21 Sep 2012].
5. Arbour R, Esparis B. (2000). Osmolar gap metabolic acidosis in a 60-year-old man treated for hypoxemic respiratory failure. Chest, 118, 545-6. (Pubitemid 30637829)
6. Agency for Toxic Substances and Disease Registry (ATSDR). (1997). Toxicological profile for propylene glycol. Available from: http://www.atsdr. cdc.gov/toxprofiles/tp189.pdf. [last accessed 21 Apr 2013].
7. Aye M, Di Giorgio C, De Mo M, et al. (2010). Assessment of the genotoxicity of three cryoprotectants used for human oocyte vitrification: dimethyl sulfoxide, ethylene glycol and propylene glycol. Food Chem Toxicol, 48, 1905-12.
8. Basketter DA, Gerberick GF, Kimber I. (1998). Strategies for identifying false positive responses in predictive skin sensitization tests. Food Chem Toxicol, 36, 327-33. (Pubitemid 28255346)
9. Bates HK, Price CJ, Marr MC, et al. (1992a). Final report on the developmental toxicity of dipropylene glycol (CAS-No. 25265-71-8) in New Zealand white rabbits. National Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709; NTIS # PB92-238294.
10. Bates HK, Price CJ, Marr MC, et al. (1992b). Final report on the developmental toxicity of dipropylene glycol (CAS-No. 25265-71-8) in Sprague-Dawley (CD) rats. National Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709; NTIS # PB92-196179.
11. Berthelot-Ricou A, Perrin J, di Giorgio C, et al. (2011). Assessment of 1,2-propanediol (PrOH) genotoxicity on mouse oocytes by comet assay. Fertility Sterility, 96, 1002-7.
12. Braun HA Cartland GF. (1936). The toxicity of propylene glycol. J Am Pharm Assoc, 25, 746-9.
13. Cavender FL, Sowinsky EJ. (2005). Patty's toxicology CD-ROM (2005). New York: John Wiley & Sons.
14. CCRIS. (1992). Chemical Carcinogenesis Research Information System from National Cancer Institute: dipropylene glycol. Available from: http://toxnet.nlm.nih.gov
15. Choi H, Schmidbauer N, Sundell J, et al. (2010a). Common household chemicals and the allergy risks in pre-school age children. PLoS One, 5, e13423.
16. Choi HK, Schmidbauer N, Spengler J, Bornehag CG. (2010b). Sources of propylene glycol and glycol ethers in air at home. Int J Env Res Public Health, 7, 4213-37.
17. Christopher MM, Eckfeldt JH, Eaton JW. (1990). Propylene glycol ingestion causes D-lactic acidosis. Laboratory Investigations, 62, 114-18. (Pubitemid 20039531)
18. Claus MA, Jandrey KE, Poppenga RH. (2011). Propylene glycol intoxication in a dog. J Vet Emerg Crit Care, 21, 679-83.
19. CFR (Code of Federal Regulations. (2011). Title 21, volume 3, 21CFR184.1666. Available from: http://www.accessdata.fda.gov/scripts/cdrh/ cfdocs/cfcfr/CFRSearch.cfm?fr1/4184.1666
20. Cosmetic Ingredient Review (CIR). (1994). Final report on the safety assessment of propylene glycol and the polypropylene glycols. J Am Coll Toxicol, 13, 437-91.
21. Doenicke A, Roizen MF, Hoeneke R, et al. (1997). Hemolysis after etomidate: comparison of propylene glycol and lipid formulations. Brit J Anaesthesia, 79, 386-8. (Pubitemid 27404058)
22. Doty JD, Sahn S. (2003). An unusual case of poisoning. South Med J, 96, 923-5. (Pubitemid 38279599)
23. Driscoll CD, Kubena MF, Neeper-Bradley TL. (1993). Propylene glycol: developmental toxicity gavage study III in CD-1 mice. Danbury (CT): industrial Chemicals Division, Union Carbide Chemicals and Plastics Company Inc. [cited in NTP NCRHR 2004].
24. European Chemicals Agency (ECHA). (2010a). REACH Dossier summary IUCLID file for 1,2-propanediol. Substance identification. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 1 Jun 2012].
25. ECHA (2010aa). REACH Dossier summary IUCLID file for 1,2-propanediol. Exp Key Genetic toxicity in vitro.004 summary. Available from: http://apps.echa. europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
26. ECHA (2010ab). REACH Dossier summary IUCLID file for 1,2-propanediol. Exp Key Genetic toxicity in vitro.005 summary. Available from: http://apps.echa. europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
27. ECHA (2010ac). REACH Dossier summary IUCLID file for 1,2-propanediol. Exp Key Genetic toxicity in vivo.002 summary. Available from: http://apps.echa. europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
28. ECHA (2010ad). REACH Dossier summary IUCLID file for 1,2-propanediol. Exp Key Genetic toxicity in vivo.003 summary. Available from: http://apps.echa. europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
29. ECHA (2010ae). REACH Dossier summary IUCLID file for [methylethylenbis( oxy)]dipropanol. Exp Key Toxicity to reproduction.001 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
30. ECHA. (2010b). REACH Dossier summary IUCLID file for. 1,2-propanediol, propxylated. Available from: http://apps.echa.europa.eu/registered/data/ dossiers. [last accessed 1 Jun 2012].
31. ECHA. (2010c). REACH Dossier summary IUCLID file for oxydipropanol. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 1 Jun 2012].
32. ECHA. (2010d). REACH Dossier summary IUCLID file for. [(methylethylene)bis(oxy)]dipropanol. Available from: http://apps.echa.europa. eu/registered/data/dossiers [last accessed 1 Jun 2012].
33. ECHA. (2010e). REACH Dossier summary IUCLID file for 1,2-propanediol. Exp Key Basic Toxicokinetics.001 summary. Available from: http://apps.echa.europa. eu/registered/data/dossiers [last accessed 1 Jun 2012].
34. ECHA. (2010f). REACH Dossier summary IUCLID file for 1,2-propanediol. Acute toxicity: Dermal.001 summary. Available from: http://apps.echa.europa.eu/ registered/data/dossiers [last accessed 1 Jun 2012].
35. ECHA (2010g.) REACH Dossier summary IUCLID file for oxydipropanol. Exp Key Acute Toxicity: Oral.001 summary. Available from: http://apps.echa.europa. eu/registered/data/dossiers [last accessed 12 Sep 2012].
36. ECHA (2010h). REACH Dossier summary IUCLID file for oxydipropanol. Exp Key Acute Toxicity: Oral.002 summary. Available from: http://apps.echa.europa. eu/registered/data/dossiers [last accessed 12 Sep 2012].
37. ECHA (2010i). REACH Dossier summary IUCLID file for oxydipropanol. Exp Key Acute Toxicity: Inhalation.001 summary. Available from: http://apps.echa. europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
38. ECHA (2010j). REACH Dossier summary IUCLID file for oxydipropanol. Exp Key Acute Toxicity: Dermal.001 summary. Available from: http://apps.echa.europa. eu/registered/data/dossiers[last accessed 12 Sep 2012].
39. ECHA (2010k). REACH Dossier summary IUCLID file for [methylethylenbis( oxy)]dipropanol: http://apps.echa.europa.eu/registered/data/dossiersExp Key Acute Toxicity: Oral.001 summary. Website accessed (09/12/2012).
40. ECHA (2010m). REACH Dossier summary IUCLID file for [methylethylenbis( oxy)]dipropanol. Exp Key Acute Toxicity: Oral.002 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
41. ECHA (2010n). REACH Dossier summary IUCLID file for [methylethylenbis( oxy)]dipropanol. Exp Key Acute Toxicity: Inhalation.001 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
42. ECHA (2010p). REACH Dossier summary IUCLID file for [methylethylenbis( oxy)]dipropanol. Exp Key Acute Toxicity: Dermal.001 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
43. ECHA (2010q). REACH Dossier summary IUCLID file for 1,2-propanediol. Exp Key Skin Irritation/Corrosion.001 summary. Available from: http://apps.echa. europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
44. ECHA (2010r). REACH Dossier summary IUCLID file for oxydipropanol. Exp Key Skin Irritation/Corrosion.001 summary. Available from: http://apps.echa. europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
45. ECHA (2010s). REACH Dossier summary IUCLID file for oxydipropanol. Exp Key Eye Irritation.001 summary. Available from: http://apps.echa.europa.eu/ registered/data/dossiers [last accessed 12 Sep 2012].
46. ECHA (2010t). REACH Dossier summary IUCLID file for [methylethylenbis( oxy)]dipropanol. Exp Key Skin Irritation.001 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
47. ECHA (2010u). REACH Dossier summary IUCLID file for [methylethylenbis( oxy)]dipropanol. Exp Key Eye Irritation.001 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
48. ECHA (2010v). REACH Dossier summary IUCLID file for [methylethylenbis( oxy)]dipropanol. Exp Key Eye Irritation.002 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
49. ECHA (2010w.) REACH Dossier summary IUCLID file for [methylethylenbis(oxy)]dipropanol. Exp Key Exposure Related observations in humans: other data.001 summary. Available from: http://apps.echa.europa.eu/ registered/data/dossiers [last accessed 12 Sep 2012].
50. ECHA (2010x). REACH Dossier summary IUCLID file for oxydipropanol. Exp Key Skin Sensitisation.001 summary. Available from: http://apps.echa.europa.eu/ registered/data/dossiers [last accessed 12 Sep 2012].
51. ECHA (2010y). REACH Dossier summary IUCLID file for 1,2-propanediol. Exp Key Repeated dose toxicity: Oral.002 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
52. ECHA (2010yy). REACH Dossier summary IUCLID file for oxydipropanol. Exp Supporting Repeated dose toxicity: Oral.004 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
53. ECHA (2010z). REACH Dossier summary IUCLID file for 1,2-propanediol. Exp Key Repeated dose toxicity: Oral.005 summary. Available from: http://apps.echa.europa.eu/registered/data/dossiers [last accessed 12 Sep 2012].
54. Fasano WJ, ten Berge WF, Banton MI, et al. (2011). Dermal penetration of propylene glycols: measured absorption across human abdominal skin in vitro and comparison with a QSAR model. Toxicology In Vitro, 25, 1664-70.
55. Food and Drug Administration (FDA) (1973). GRAS substance review: propylene glycol. Available from: http://www.accessdata.fda.gov/scripts/fcn/ fcnDetailNavigation.cfm?rpt1/4scogslisting&id1/4262. [last accessed 20 Sep 2012].
56. FDA. (1996). 21 C.F.R. x 582.1666(b), as issued in 61 Fed. Reg. 19542 (May 2, 1996).
57. Fiume MM, Bergfeld WF, Belsito DV, et al. (2012). Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics. Int J Toxicol, 31, 245S-60S.
58. Food and Drug Research Laboratories, Inc. (FDRL). (1973). Teratologic evaluation of FDA 71-56 (propylene glycol) in mice, rats, hamsters and rabbits. Waverely (NY): Food and Drug Research Laboratories, Inc. [cited in NTP 2004a].
59. Funk JO, Maibach HI. (1994). Propylene glycol dermatitis: re-evaluation of an old problem. Contact Dermatitis, 31, 236-41. (Pubitemid 24311533)
60. Gallenkemper G, Rabe E, Bauer R. (1998). Contact sensitization in chronic venous insufficiency; modern wound dressings. Contact Dermatitis, 38, 274-8. (Pubitemid 28274282)
61. Gaunt IF, Carpanini FMB, Grasso P, Lansdown ABG. (1972). Long-term toxicity of propylene glycol in rats. Food Cosmet Toxicol, 10, 151-62.
62. Guerrant N, Whitlock G, Wolff M, Dutcher R. (1947). Response of rats to diets containing varying amounts of glycerol and propylene glycol. Bull Nat Formul Comm, 15, 205-29. [cited in NTP CERHR, 2004].
63. Guillot JP, Gonnet JF, Clément C, Faccini JM. (1983). Comparative study of methods chosen by the Association Française de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig. Food Chem Toxicol, 21, 795-805. (Pubitemid 14216194)
64. Haley DP, Bulger RP. (1983). The aging male rat: structure and function of the kidney. Am J Anatom, 167, 1-13. (Pubitemid 13103585)
65. Hard GC (2002). Expert report on renal histopathologic changes in rat toxicology studies with dipropylene glycol. American Chemistry Council, Propylene oxide/Propylene glycol panel, Arlington, USA. Report no.: PO1-NTP2-Hard. Report date: 2002-08-01.
66. Hard GC, Johnson KJ, Cohen SM. (2009). A comparison of rat chronic progressive nephropathy with human renal disease-implications for human risk assessment. Crit Rev Toxicol, 39, 332-46.
67. Harkema J. (2002). Histopathologic evaluation of nasal tissues from male and female rats in the NTP two year chronic inhalation study of dipropylene glycol (DPG) (C88031B/88031-05) for the, American Chemistry Council.
68. Hayashi M, Kishi M, Sofuni T, Ishidate M. (1988). Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals. Fd Chem Toxicol, 26, 487-500.
69. Hayman M, Seidl E, Ali M, Malik K. (2003). Acute tubular necrosis associated with propylene glycol from concomitant administration of intravenous lorazepam and trimethoprim-sulfamethazole. Pharmacotherapy, 23, 1190-4. (Pubitemid 37158787)
70. Ishidate M, Sofuni K, Yoshikawa K, Hayashi M, Nohmi T, Sawada M and Matsuoka A. (1984). Primary mutagenicity screening of food additives currently used in Japan. Food Cosmet Toxicol, 22, 623-36. (Pubitemid 14097032)
71. Ishiwata H. (1999). Daily intake of food additives and comparison with acceptable daily intake. Bull Dept Med Sci, 41, 79-89.
72. Jacobs GA. (1988). OECD Eye irritation tests on propylene glycol and Solketal. J Am College Toxicol, 11, 739.
73. Johansen JD, Jemec GBE, Rastogi SC. (1995). Contact sensitization to dipropylene glycol in an eczema population. Contact Dermatitis, 33, 211-12.
74. Kavlock RJ, Short Jr RD, Chernoff N. (1987). Further evaluation of an in vivo teratology screen. Teratog Carcinog Mutagen, 7, 7-16. (Pubitemid 17053325)
75. Kero M, Hannuksela M. (1980). Guinea pig maximization test, open epicutaneous test and chamber test in induction of delayed contact hypersensitivity. Contact Dermatitis, 6, 341-4. (Pubitemid 11254876)
76. Kimber I, Pieters R. (2012). Household chemicals, immune function, and allergy: a commentary. J, Immunotoxicol [epub ahead of print, Sept 7]. DOI: 10.3109/1547691X.2012.707696.
77. Kirschner M. (2007). US end use pattern for propylene glycol in 2007. ICIS Chemical Business, 272, 58-60.
78. Konradova V, Vavrova V, Janota J. (1978). Effect of the inhalation of a surface tension-reducing substance (propylene glycol) on the ultrastructure of the epithelium of the respiratory passages in rabbits. Folia Morphol, 26, 28-34. (Pubitemid 8275816)
79. Kulo A, DeHoon JN, Allegaert K. (2012). The propylene glycol research project to illustrate the feasibility and difficulties to study toxicokinetics in neonates. Int J Pharm, 435, 112-14.
80. LaKind J, McKenna EA, Hubner RP, Tardiff RG. (1999). A review of the comparative mammalian toxicity of ethylene glycol and propylene glycol. Crit Rev Toxicol, 29, 331-65. (Pubitemid 29379096)
81. Laug EP, Calvery HO, Morris HJ, Woodard G. (1939). The toxicology of some glycols and derivatives. J Ind Hyg Tox, 21, 173-201.
82. Lessmann H, Schnuch A, Geier J, Uter W. (2005). Skin sensitizing and irritant properties of propylene glycol. Contact Dermatitis, 53, 247-59. (Pubitemid 41719274)
83. Lovecchio F, Nourani C, Watts D, et al. (2008). Acute renal failure, neuropathy, and myopathy after ingestion of dipropylene glycol fog solution. Am J Emergency Med, 26, 635.e1-2.
84. MacDonald MG, Getson PR, Glasgow AM, et al. (1987). Propylene glycol: Increased incidence of seizures in low birth weight infants. Pediatrics, 79, 622-5. (Pubitemid 17051431)
85. MacKee GM, Sulzeberger MB, Herrmann F, Baer RL. (1945). Histologic studies on percutaneous penetration with special reference to the effect of vehicles. J Ingest Dermatol, 6, 43-61 [cited in NTP NCRHR, 2004].
86. Martin AE, Murphy FH. (2000). Glycols, propylene glycols. Kirk-Othmer encyclopedia of chemical technology. New York: John Wiley & Sons Inc.
87. Morris HJ, Nelson AA, Calvery HO. (1941). Observations on the chronic toxicities of propylene glycol, ethylene glycol, diethylene glycol, ethylene glycol mono-ethyl-ether, and diethylene glycol mono-ethyl-ether. J Pharmacol Exper Therap, 74, 266-73.
88. Morrissey RE, Lamb IV, JC, Morris RW, et al. (1989). Results and evaluations of 48 continuous breeding reproduction studies conducted in mice. Fundam Appl Toxicol, 13, 747-77. (Pubitemid 20061133)
89. National Institute for Occupational Safety and Health (NIOSH). (1983). National Occupational Exposure Survey for 1981-1983. Available from: http://www.cdc.gov/noes/noes1/63525sic.html [last accessed Sep 2012].
90. National Toxicology Program (NTP). (1985). Propylene glycol: reproduction and fertility assessment in CD-1 mice when administered in drinking water. National Toxicology Program, National Institute of Environmental Health Sciences. Testing laboratory: Environmental Health Research and Testing, Inc., 2514 Regency Road, Suite 105, Lexington, KY 40503, USA; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Report no.: NTP-85-321.
91. NTP. (2004a). Center for the Evaluation of Risks to Human Reproduction (CERHR). NTP-CERHR expert panel report on the reproductive and developmental toxicity of propylene glycol. NIH publication No. 04-4482. March 2004.
92. NTP. (2004b). Toxicology and Carcinogenesis studies of dipropylene glycol in F344/N rats and B6C3F1 mice. NTP Technical Report TR 511.
93. Organization for Economic Cooperation and Development (OECD). (2001) SIDS Initial assessment report for 11th SIAM. Washington DC.
94. Pfeiffer EH, Dunkelberg H. (1980). Mutagenicity of ethylene oxide and propylene oxide and of the glycols and halohydrins formed from them during the fumigation of foodstuffs. Food Cosmet Toxicol, 18, 115-18. (Pubitemid 11252091)
95. Robertson OH, Loosli CG, Puck TT, et al. (1947). Tests for the chronic toxicity of propylene glycol and triethylene glycol on monkeys and rats by vapor inhalation and oral administration. J Pharmacol Exp Ther, 91, 52-76.
96. Ruddick JA. (1972). Toxicology, metabolism, and biochemistry of 1,2-propanediol. Toxicol Appl Pharmacol, 21, 102-11.
97. Seidenfeld MA, Hanzlik PJ. (1932). The general properties, actions and toxicity of propylene glycol. J Pharmacol Exp Therap, 44, 109.
98. Stenbäck F, Shubik P. (1974). Lack of toxicity and carcinogenicity of some commonly used cutaneous agents. Toxicol Appl Pharmacol, 30, 7-13.
99. Suber RL, Deskin R, Nikiforov I, et al. (1989). Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats. Fd Chem Toxic, 27, 573-83. (Pubitemid 19270915)
100. United States Environmental Protection Agency (USEPA). (2006). Reregistration eligibility decision for propylene glycol and dipropylene glycol. Office of Prevention, Pesticides and Toxic Substances. EPA-739-R-06-002.
101. United National Globally Harmonized System for the Classification of Chemicals (UN GHS). (2011). Available from: http://www.unece. org/trans/danger/publi/ghs/ghs-rev04/04files-e.html [last accessed Feb 2013].
102. Vaille C, Debray C, Roze C, et al. (1971). Hyperglycemic action of propylene glycol. Ann Pharam Franc, 29, 577-82.
103. Weatherby JH, Haag HB. (1938). Toxicity of propylene glycol. J Am Pharmacol Assoc, 27, 466-71. [cited in NTP 2004a].
104. Weil CS, Woodside MD, Smyth HF, Carpenter CP. (1971). Results of feeding propylene glycol in the diet of dogs for two years. Food Cosmet Toxicol, 9, 479-90.
105. Werley MS, McDonald P, Lilly P, et al. (2011). Non-clinical safety and pharmacokinetic evaluations of propylene glycol aerosol in Sprague-Dawley rats and Beagle dogs. Toxicology, 287, 76-90.
106. Yu DK, Elmquist WF, Sawchuk RJ. (1985). Pharmacokinetics of propylene glycol in humans during multiple dosing regimens. J Pharm Sci, 74, 876-9. (Pubitemid 15042180)
107. Zar T, Graeber C, Perazella MA. (2007). Recognition, treatment, and prevention of propylene glycol toxicity. Semin Dial, 20, 217-19.
108. Zosel A, Egelhoff E, Heard K. (2010). Severe lactic acidosis after an iatrogenic propylene glycol overdose. Pharmacotherapy, 30, 219.
109. Zug KA, Rietschel R, Warshaw EM, et al. (2008). The value of patch testing patients with a scattered generalized distribution of dermatitis: retrospective cross-sectional analyses of North American Contact Dermatitis Group data, 2001 to 2004. J Am Acad Dermatol, 59, 426-31.