B56-PP2A regulates motor dynamics for mitotic chromosome alignment

Journal of Cell Science

Volumn 127, Issue 21, 2014, Pages 4567-4573

  Xu, Peng ^a,b   Virshup, David M ^a   Lee, Sang Hyun ^a  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

BUBR1; Chromosome congression; Kinesin; Mitosis; PP2A

Indexed keywords

B56 PP2A PROTEIN; HSET PROTEIN; MOLECULAR MOTOR; PHOSPHOPROTEIN PHOSPHATASE 2A; UNCLASSIFIED DRUG; BUB1 PROTEIN, HUMAN; HUMAN SPLEEN, EMBRYO, AND TESTES EXPRESSED PROTEIN, HUMAN; KINESIN; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2R5A PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CHROMOSOMAL INSTABILITY; CHROMOSOME; CHROMOSOME ALIGNMENT; CHROMOSOME MOVEMENT; CHROMOSOME STRUCTURE; CONTROLLED STUDY; GENE FUNCTION; HUMAN; HUMAN CELL; K FIBER; KINETOCHORE MICROTUBULE; METAPHASE; MITOSIS; MOLECULAR DYNAMICS; PROTEIN DEPLETION; GENETICS; HELA CELL LINE; HUMAN CHROMOSOME; IMMUNOBLOTTING; METABOLISM; PHYSIOLOGY;

CHROMOSOMES, HUMAN; HELA CELLS; HUMANS; IMMUNOBLOTTING; KINESIN; MITOSIS; PROTEIN BINDING; PROTEIN PHOSPHATASE 2; PROTEIN-SERINE-THREONINE KINASES;

EID: 84913570740     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.154609     Document Type: Article

References (33)

1. Cai, S. and Walczak, C. E. (2009). The road less traveled to the spindle equator. Cell Cycle 8, 3791-3793.
2. Cai, S., O'Connell, C. B., Khodjakov, A. andWalczak, C. E. (2009a). Chromosome congression in the absence of kinetochore fibres. Nat. Cell Biol. 11, 832-838.
3. Cai, S., Weaver, L. N., Ems-McClung, S. C. and Walczak, C. E. (2009b). Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol. Biol. Cell 20, 1348-1359.
4. Cheeseman, I. M., Chappie, J. S., Wilson-Kubalek, E. M. and Desai, A. (2006). The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127, 983-997.
5. DeLuca, J. G., Moree, B., Hickey, J. M., Kilmartin, J. V. and Salmon, E. D. (2002). hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J. Cell Biol. 159, 549-555.
6. DeLuca, K. F., Lens, S. M. A. and DeLuca, J. G. (2011). Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis. J. Cell Sci. 124, 622-634.
7. Foley, E. A. and Kapoor, T. M. (2009). Chromosome congression: on the bi-orient express. Nat. Cell Biol. 11, 787-789.
8. Foley, E. A., Maldonado, M. and Kapoor, T. M. (2011). Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase. Nat. Cell Biol. 13, 1265-1271.
9. Forester, C. M., Maddox, J., Louis, J. V., Goris, J. and Virshup, D. M. (2007). Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proc. Natl. Acad. Sci. USA 104, 19867-19872.
10. Jin, F., Liu, H., Li, P., Yu, H.-G. and Wang, Y. (2012). Loss of function of the Cik1/ Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint. PLoS Genet. 8, e1002492.
11. Kapoor, T. M., Lampson, M. A., Hergert, P., Cameron, L., Cimini, D., Salmon, E. D., McEwen, B. F. and Khodjakov, A. (2006). Chromosomes can congress to the metaphase plate before biorientation. Science 311, 388-391.
12. Kops,G.J. P. L., Saurin, A. T. andMeraldi, P. (2010). Finding themiddle ground: how kinetochores power chromosome congression. Cell. Mol. Life Sci. 67, 2145-2161.
13. Kruse, T., Zhang, G., Larsen, M. S. Y., Lischetti, T., Streicher, W., Kragh Nielsen, T., Bjørn, S. P. and Nilsson, J. (2013). Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression. J. Cell Sci. 126, 1086-1092.
14. Lesage, B., Qian, J. and Bollen, M. (2011). Spindle checkpoint silencing: PP1 tips the balance. Curr. Biol. 21, R898-R903.
15. Li, Y., Yu, W., Liang, Y. and Zhu, X. (2007). Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment. Cell Res. 17, 701-712.
16. Liu, D., Vleugel, M., Backer, C. B., Hori, T., Fukagawa, T., Cheeseman, I. M. and Lampson, M. A. (2010). Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J. Cell Biol. 188, 809-820.
17. Mattiuzzo, M., Vargiu, G., Totta, P., Fiore, M., Ciferri, C., Musacchio, A. and Degrassi, F. (2011). Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1. PLoS ONE 6, e16307.
18. McClelland, S. E., Borusu, S., Amaro, A. C., Winter, J. R., Belwal, M., McAinsh, A. D. and Meraldi, P. (2007). The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. EMBO J. 26, 5033-5047.
19. Palmer, K. J., Hughes, H. and Stephens, D. J. (2009). Specificity of cytoplasmic dynein subunits in discrete membrane-trafficking steps. Mol. Biol. Cell 20, 2885-2899.
20. Posch, M., Khoudoli, G. A., Swift, S., King, E. M., Deluca, J. G. and Swedlow, J. R. (2010). Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis. J. Cell Biol. 191, 61-74.
21. Rieder, C. L. (1981). The structure of the cold-stable kinetochore fiber in metaphase PtK1 cells. Chromosoma 84, 145-158.
22. Shrestha, R. L. and Draviam, V. M. (2013). Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr. Biol. 23, 1514-1526.
23. Stumpff, J., Wagenbach, M., Franck, A., Asbury, C. L. and Wordeman, L. (2012). Kif18A and chromokinesins confine centromere movements via microtubule growth suppression and spatial control of kinetochore tension. Dev. Cell 22, 1017-1029.
24. Suijkerbuijk, S. J. E., Vleugel, M., Teixeira, A. and Kops, G. J. P. L. (2012). Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments. Dev. Cell 23, 745-755.
25. Tanaka, T. U. and Desai, A. (2008). Kinetochore-microtubule interactions: the means to the end. Curr. Opin. Cell Biol. 20, 53-63.
26. Tanaka, K., Mukae, N., Dewar, H., van Breugel, M., James, E. K., Prescott, A. R., Antony, C. and Tanaka, T. U. (2005). Molecular mechanisms of kinetochore capture by spindle microtubules. Nature 434, 987-994.
27. Tanaka, K., Kitamura, E., Kitamura, Y. and Tanaka, T. U. (2007). Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles. J. Cell Biol. 178, 269-281.
28. Virshup, D. M. and Shenolikar, S. (2009). From promiscuity to precision: protein phosphatases get a makeover. Mol. Cell 33, 537-545.
29. Wandke, C., Barisic, M., Sigl, R., Rauch, V., Wolf, F., Amaro, A. C., Tan, C. H., Pereira, A. J., Kutay, U., Maiato, H. et al. (2012). Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis. J. Cell Biol. 198, 847-863.
30. Welburn, J. P. I., Vleugel, M., Liu, D., Yates, J. R., III, Lampson, M. A., Fukagawa, T. and Cheeseman, I. M. (2010). Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol. Cell 38, 383-392.
31. Wong, J., Nakajima, Y., Westermann, S., Shang, C., Kang, J.-S., Goodner, C., Houshmand, P., Fields, S., Chan, C. S. M., Drubin, D. et al. (2007). A protein interaction map of the mitotic spindle. Mol. Biol. Cell 18, 3800-3809.
32. Xu, P., Raetz, E. A., Kitagawa, M., Virshup, D. M. and Lee, S. H. (2013). BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression. Biol. Open 2, 479-486.
33. Yang, Z., Tulu, U. S., Wadsworth, P. and Rieder, C. L. (2007). Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint. Curr. Biol. 17, 973-980.