Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 11, 2014, Pages H1626-H1633

  Kato, Ryuji ^a   Nomura, Atsuo ^a   Sakamoto, Aiji ^b   Yasuda, Yuki ^a   Amatani, Koyuha ^a   Nagai, Sayuri ^a   Sen, Yoko ^a   Ijiri, Yoshio ^a   Okada, Yoshikatsu ^a   Yamaguchi, Takehiro ^c   Izumi, Yasukatsu ^c   Yoshiyama, Minoru ^c   Tanaka, Kazuhiko ^a   Hayashi, Tetsuya ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiomyopathic hamster; Heart failure; Hydrogen gas; Intermittent hypoxia; Oxidative stress

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; HYDROGEN; MESSENGER RNA; MYOSIN HEAVY CHAIN BETA; PROTEIN C FOS; PROTEIN C JUN; SUPEROXIDE; 4-HYDROXY-2-NONENAL; ALDEHYDE; CYSTEINE PROTEINASE INHIBITOR; GAS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CARDIOMYOPATHY; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DIASTOLIC MITRAL INFLOW VELOCITY; ECHOCARDIOGRAPHY; GENE EXPRESSION; HAMSTER; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE REMODELING; HEART MUSCLE; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART VENTRICLE REMODELING; HEART WEIGHT; HISTOLOGY; INTERMITTENT HYPOXIA; MALE; MITRAL ANNULUS VELOCITY; NONHUMAN; OXIDATIVE STRESS; PROGNOSIS; PROTEIN EXPRESSION; SLEEP DISORDERED BREATHING; ANIMAL; ANOXIA; DRUG EFFECTS; ECHOGRAPHY; GAS; GENE EXPRESSION REGULATION; GENETICS; HEART VENTRICLE; MESOCRICETUS; METABOLISM; ORGAN SIZE; PATHOLOGY;

ALDEHYDES; ANIMALS; ANOXIA; BODY WEIGHT; CARDIOMYOPATHIES; CRICETINAE; CYSTEINE PROTEINASE INHIBITORS; GASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART VENTRICLES; HYDROGEN; MESOCRICETUS; ORGAN SIZE; SUPEROXIDES; VENTRICULAR REMODELING;

EID: 84913554568     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00228.2014     Document Type: Article

References (34)

1. Arias MA, García-Río F, Alonso-Fernández A, Mediano O, Martínez I, Villamor J. Obstructive sleep apnea syndrome affects left ventricular diastolic function: effects of nasal continuous positive airway pressure in men. Circulation 112: 375–383, 2005.
2. Baguet JP, Narkiewicz K, Mallion JM. Update on hypertension management: obstructive sleep apnea and hypertension. J Hypertens 24: 205–208, 2006.
3. Blanchette J, Abu-Dayyeh I, Hassani K, Whitcombe L, Olivier M. Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1). Immunology 127: 123–133, 2009.
4. Chen L, Einbinder E, Zhang Q, Hasday J, Balke CW, Scharf SM. Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats. Am J Respir Crit Care Med 172: 915–920, 2005.
5. Chen L, Zhang J, Gan TX, Chen-Izu Y, Hasday JD, Karmazyn M, Balke CW, Scharf SM. Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia. J Appl Physiol 104: 218–223, 2008.
6. Christl SU, Murgatroyd PR, Gibson GR, Cummings JH. Production, metabolism, and excretion of hydrogen in the large intestine. Gastroen-terology 102: 1269–1277, 1992.
7. Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B. IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1. Am J Physiol Heart Circ Physiol 293: H3356–H3365, 2007.
8. Duran JM, Makarewich CA, Trappanese D, Gross P, Husain S, Dunn J, Lal H, Sharp TE, Starosta T, Vagnozzi RJ, Berretta RM, Barbe M, Yu D, Gao E, Kubo H, Force T, Houser SR. Sorafenib cardiotoxicity increases mortality after myocardial infarction. Circ Res 114: 1700–1712, 2014.
9. Fan H, Sun B, Gu Q, Lafond-Walker A, Cao S, Becker LC. Oxygen radicals trigger activation of NF-kappaB and AP-1 and upregulation of ICAM-1 in reperfused canine heart. Am J Physiol Heart Circ Physiol 282: H1778–H1786, 2002.
10. Gottlieb DJ, Yenokyan G, Newman AB, O’Connor GT, Punjabi NM, Quan SF, Redline S, Resnick HE, Tong EK, Diener-West M, Shahar E. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation 122: 352–360, 2010.
11. Hastings PC, Vazir A, Meadows GE, Dayer M, Poole-Wilson PA, McIntyre HF, Morrell MJ, Cowie MR, Simonds AK. Adaptive servo-ventilation in heart failure patients with sleep apnea: a real world study. Int J Cardiol 139: 17–24, 2010.
12. Hayashi T, James TN, Buckingham DC. Ultrastructure and immuno-histochemistry of the coronary chemoreceptor in human and canine hearts. Am Heart J 129: 946–959, 1995.
13. Hayashi T, Yoshioka T, Hasegawa K, Miyamura M, Mori T, Ukimura A, Matsumura Y, Ishizaka N. Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. Am J Physiol Heart Circ Physiol 301: H1062–H1069, 2011.
14. Hsu TC, Young MR, Cmarik J, Colburn NH. Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic Biol Med 28: 1338–1348, 2000.
15. Inamoto S, Yoshioka T, Yamashita C, Miyamura M, Mori T, Ukimura A, Matsumoto C, Matsumura Y, Kitaura Y, Hayashi T. Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice. Hypertens Res 33: 579–586, 2010.
16. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 169: 348–353, 2004.
17. Javaheri S. Heart failure. In: Principles and Practice of Sleep Medicine (5th ed.), edited by Kryger MH, Roth T, and Dement WC. St. Louis: Saunders, 2011, p. 1400–1415.
18. Kasai T. Sleep apnea and heart failure. J Cardiol 60: 78–85, 2012.
19. Lattimore JD, Celermajer DS, Wilcox I. Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol 41: 1429–1437, 2003.
20. Maeda H, Nagai H, Takemura G, Shintani-Ishida K, Komatsu M, Ogura S, Aki T, Shirai M, Kuwahira I, Yoshida K. Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart. Biochim Biophys Acta 832: 1159–1166, 2013.
21. Nadruz W, Jr., Kobarg CB, Kobarg J, Franchini KG. c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart. Am J Physiol Heart Circ Physiol 286: H760–H767, 2004.
22. Nakao A, Sugimoto R, Billiar TR, McCurry Therapeutic antioxidant medical gas. J Cli Biochem Nutr 44: 1–13, 2009.
23. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13: 688–694, 2007.
24. Ohta S. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther 144: 1–11, 2014.
25. Okuda N, Ito T, Emura N, Suwa M, Hayashi T, Yoneda H, Kitaura Y. Depressed myocardial contractile reserve in patients with obstructive sleep apnea assessed by tissue Doppler imaging with dobutamine stress echo-cardiography. Chest 131: 1082–1089, 2007.
26. Partinen M, Guilleminault C. Daytime sleepiness and vascular morbidity at seven-year follow-up in obstructive sleep apnea patients. Chest 97: 27–32, 1990.
27. Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sci 54: 705–712, 2009.
28. Sakamoto A, Abe M, Masaki T. Delineation of genomic deletion in cardiomyopathic hamster. FEBS Lett 447: 124–128, 1994.
29. Sakamoto A, Sugamoto Y. Identification of a novel aldose reductase-like gene upregulated in the failing heart of cardiomyopathic hamster. Mol Cell Biochem 353: 275–281, 2011.
30. Shen G, Jeong WS, Hu R, Kong AN. Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents. Antioxid Redox Signal 7: 1648–1663, 2005.
31. Vatta M, Sinagra G, Brunelli L, Faulkner G. Remodeling of dystrophin and sarcomeric Z-band occurs in pediatric cardiomyopathies: a unifying mechanism for force transmission defect. J Cardiovasc Med 10: 149–156, 2009.
32. Williams AL, Chen L, Scharf SM. Effects of allopurinol on cardiac function and oxidant stress in chronic intermittent hypoxia. Sleep Breath 14: 51–57, 2010.
33. Yamashita C, Hayashi T, Mori T, Tazawa N, Kwak CJ, Nakano D, Sohmiya K, Okada Y, Kitaura Y, Matsumura Y. Angiotensin-II receptor blocker reduces oxidative stress and attenuates hypoxia-induced left ventricular remodeling in apolipoprotein E-knockout mice. Hypertens Res 30: 1219–1230, 2007.
34. Yoshiyama M, Takeuchi K, Hanatani A, Shimada T, Takemoto Y, Shimizu N, Omura T, Kim S, Iwao H, Yoshikawa J. Effect of cilazapril on ventricular remodeling assessed by Doppler-echocardiographic assessment and cardiac gene expression. Cardiovasc Drugs Ther 12: 57–70, 1998.