Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia

Journal of Applied Physiology

Volumn 104, Issue 1, 2008, Pages 218-223

  Chen, Ling ^a   Zhang, Jin ^a   Gan, Tracey X ^b   Chen Izu, Ye ^c   Hasday, Jeffrey D ^a   Karmazyn, Morris ^b   Balke, C William ^c   Scharf, Steven M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Apoptosis; Cardiac hypertrophy; Obstructive sleep apnea

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CASPASE 3; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE; MYOSIN HEAVY CHAIN BETA; MYOSIN LIGHT CHAIN 2; PROTEIN C FOS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL COUNT; CELL DAMAGE; CELL LEVEL; CELL SIZE; CONTROLLED STUDY; DIASTOLE; ENZYME ACTIVITY; HEART CATHETERIZATION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART OUTPUT; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HYPOXIA; MALE; MARKER GENE; MEAN ARTERIAL PRESSURE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMERE; SYSTOLE;

ANIMALS; ANOXIA; APOPTOSIS; ATRIAL NATRIURETIC FACTOR; BLOOD PRESSURE; BODY WEIGHT; CARDIAC MYOSINS; CARDIAC OUTPUT; CARDIOMEGALY; CASPASE 3; CELL SIZE; CHRONIC DISEASE; COLLAGEN; DISEASE MODELS, ANIMAL; HYPERTROPHY; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; MYOSIN HEAVY CHAINS; MYOSIN LIGHT CHAINS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RESEARCH DESIGN; RNA, MESSENGER; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR PRESSURE; VENTRICULAR REMODELING;

EID: 38349003002     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00301.2007     Document Type: Article

References (38)

1. Bao G, Randhawa PM, Fletcher EC. Acute blood pressure elevation during repetitive hypocapnic and eucapnic hypoxia in rats. J Appl Physiol 82: 1071-1078, 1997.
2. Bao G, Metreveli N, Li R, Taylor A, Fletcher EC. Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system. J Appl Physiol 83: 95-101, 1997.
3. Campen MJ, Shimoda LA, O'Donnell CP. Acute and chronic cardiovascular effects of intermittent hypoxia in C57BL/6J mice. J Appl Physiol 99: 2028-2035, 2005.
4. Chen L, Chen CX, Gan XT, Beier N, Scholz W, Karmazyn M. Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition. Am J Physiol Heart Circ Physiol 286: H381-H387, 2004.
5. Chen L, Einbinder E, Zhang Q, Hasday J, Balke CW, Scharf SM. Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats. Am J Respir Crit Care Med 172: 915-920, 2005.
6. Chen-Izu Y, McCulle SL, Ward CW, Soeller C, Allen BM, Rabang C, Cannell MB, Balke CW, Izu LT. Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J 91: 1-13, 2006.
7. Diez J, Gonzalez A, Lopez B, Querejeta R. Mechanisms of disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease. Nat Clin Pract Cardiovasc Med 2: 209-216, 2005.
8. Fagan KA. Pulmonary hypertension in mice following intermittent hypoxia. J Appl Physiol 90: 2502-2507, 2001.
9. Fletcher EC, Lesske J, Behm R, Miller CC 3rd, Stauss H, Unger T. Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea. J Appl Physiol 72: 1978-1984, 1992.
10. Fletcher EC, Lesske J, Qian W, Miller CC 3rd, Unger T. Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats. Hypertension 19: 555-561, 1992.
11. Fletcher EC, Lesske J, Culman J, Miller CC, Unger T. Sympathetic denervation blocks blood pressure elevation in episodic hypoxia. Hypertension 20: 612-619, 1992.
12. Fletcher EC, Bao G, Miller CC 3rd. Effect of recurrent episodic hypocapnic, eucapnic, and hypercapnic hypoxia on systemic blood pressure. J Appl Physiol 78: 1516-1521, 1995.
13. Fletcher EC, Orolinova N, Bader M. Blood pressure response to chronic episodic hypoxia: the renin-angiotensin system. J Appl Physiol 92: 627-633, 2002.
14. Frey N, Katus HA, Olson EN, Hill JA. Hypertrophy of the heart: a new therapeutic target? Circulation 109: 1580-1589, 2004.
15. Gerdes AM, Kellerman SE, Moore JA, Muffly KE, Clark LC, Reaves PY, Malec KB, McKeown PP, Schocken DD. Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy. Circulation 86; 426-430, 1992.
16. Greenberg HE, Sica A, Batson D, Scharf SM. Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia. J Appl Physiol 86: 298-305, 1999.
17. Greenberg HE, Sica AL, Scharf SM, Ruggiero DA. Expression of c-fos in the rat brainstem after chronic intermittent hypoxia. Brain Res 816: 638-645, 1999.
18. Hoshijima M, Chien KR. Mixed signals in heart failure: cancer rules. J Clin Invest 109: 849-855, 2002.
19. Katz AM. Heart failure. In: Physiology of the Heart (3rd ed.), edited by Katz AM. Philadelphia, PA: Lippincott Williams and Wilkins, 2001, p. 658-94.
20. Kobayashi T, Solaro RJ. Calcium, thin filaments, and the integrative biology of cardiac contractility. Annu Rev Physiol 67: 39-67, 2005.
21. Kuwahara F, Kai H, Tokuda K, Takeya M, Takeshita A, Egashira K, Imaizumi T. Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation? Hypertension 43: 739-745, 2004.
22. Landmesser U, Drexler H. Chronic heart failure: an overview of conventional treatment versus novel approaches. Nat Clin Pract Cardiovasc Med 2: 628-638, 2005.
23. Lee SD, Kuo WW, Lin JA, Chu YF, Wang CK, Yeh YL, Wang SG, Liu JY, Chang MH, Huang CY. Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts. Int J Cardiol 116: 348-356, 2007.
24. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322: 1561-1566, 1990.
25. Manso AM, Elsherif L, Kang SM, Ross RS. Integrins, membrane-type matrix metalloproteinases and ADAMs: Potential implications for cardiac remodeling. Cardiovasc Res 69: 574-584, 2006.
26. McGuire M, Bradford A. Chronic intermittent hypoxia increases haematocrit and causes right ventricular hypertrophy in the rat. Respir Physiol 117: 53-58, 1999.
27. McGuire M, Bradford A. Chronic intermittent hypercapnic hypoxia increases pulmonary arterial pressure and haematocrit in rats. Eur Respir J 18: 279-285, 2001.
28. Nicoletti A, Michel JB. Cardiac fibrosis and inflammation: interaction with hemodynamic and hormonal factors. Cardiovasc Res 41: 532-543, 1999.
29. Park AM, Suzuki YJ. Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice. J Appl Physiol 102: 1806-1814, 2007.
30. Parish JM, Somers VK. Obstructive sleep apnea and cardiovascular disease. Mayo Clin Proc 79: 1036-1046, 2004.
31. Roos KP. Mechanics and force production. In: The Myocardium (2nd ed.), edited by Langer GA. San Diego, CA: Academic, 1997, p. 235-323.
32. Sabri A, Hughie HH, Lucchesi PA. Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes. Antioxid Redox Signal 5: 731-740, 2003.
33. Scharf SM, Chen L, Greenburg H, O'Donnel CP. Cardiovascular response to obstructive apneas: lessons from animal models. In: Respiratory-Circulatory Interactions in Health and Disease, edited by Scharf SM, Pinsky M, Magdar S. New York: Dekker, 2001, p. 613-740. (Lung Biol Health Dis Ser).
34. Shorofsky SR, Aggarwal R, Corretti M, Baffa JM, Strum JM, Al-Seikhan BA, Kobayashi YM, Jones LR, Wier WG, Balke CW. Cellular mechanisms of altered contractility in the hypertrophied heart: big hearts, big sparks. Circ Res 84: 424-434, 1999.
35. Sica AL, Greenberg HE, Scharf SM, Ruggiero DA. Chronic-intermittent hypoxia induces immediate early gene expression in the midline thalamus and epithalamus. Brain Res 883: 224-228, 2000.
36. Takemura G, Fujiwara H. Role of apoptosis in remodeling after myocardial infarction. Pharmacol Ther 104: 1-16, 2004.
37. ATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes. J Pharmacol Exp Ther 320: 14-21, 2007.
38. Xu W, Chi L, Row BW, Xu R, Ke Y, Xu B, Luo C, Kheirandish L, Gozal D, Liu R. Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea. Neuroscience 126: 313-323, 2004.