Loratadine and analogues: Discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B0AT2

Journal of Medicinal Chemistry

Volumn 57, Issue 22, 2014, Pages 9473-9479

  Cuboni, Serena ^a   Devigny, Christian ^a,d   Hoogeland, Bastiaan ^a,e   Strasser, Andrea ^b   Pomplun, Sebastian ^a   Hauger, Barbara ^a   Höfner, Georg ^c   Wanner, Klaus T ^c   Eder, Matthias ^a   Buschauer, Armin ^b   Holsboer, Florian ^a   Hausch, Felix ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d Hoffmann Eitle   (Germany)

^e Hamilton Robotics GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (HYDROXYMETHYL)LORATADINE; 2 (METHOXYCARBONYL)LORATADINE; 2 CYANOLORATADINE; 3 HYDROXYLORATADINE; 3 METHOXYLORATADINE; 4 (HYDROXYMETHYL)LORATADINE; 4 CYANOLORATADINE; AMINO ACID TRANSPORTER; AT2 PROTEIN; HISTAMINE H1 RECEPTOR ANTAGONIST; LORATADINE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; HISTAMINE H1 RECEPTOR; NERVE PROTEIN; SLC6A15 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; IC50; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; BRAIN; CELL MEMBRANE; CHEMISTRY; DRUG EFFECTS; HEK293 CELL LINE; KINETICS; MEDICINAL CHEMISTRY; METABOLISM; PATCH CLAMP TECHNIQUE; PROCEDURES;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; BINDING, COMPETITIVE; BRAIN; CELL MEMBRANE; CHEMISTRY, PHARMACEUTICAL; ELECTROPHYSIOLOGY; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LORATADINE; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; RECEPTORS, HISTAMINE H1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84913533921     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501086v     Document Type: Article

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