Imaging of N-Linked glycans from formalin-fixed paraffin-embedded tissue sections using MALDI mass spectrometry

ACS Chemical Biology

Volumn 9, Issue 9, 2014, Pages 2149-2156

  Eshghi, Shadi Toghi ^a   Yang, Shuang ^b   Wang, Xiangchun ^b   Shah, Punit ^b   Li, Xingde ^a   Zhang, Hui ^b  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORMALDEHYDE; GLYCAN; GLYCAN DERIVATIVE; GLYCOPEPTIDASE; MANNOSE OLIGOSACCHARIDE; PARAFFIN; POLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; BRAIN TISSUE; C57BL 6 MOUSE; EMBEDDING; GLIOBLASTOMA CELL LINE; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NEOCORTEX; NEUROIMAGING; NOD SCID MOUSE; NONHUMAN; TISSUE SECTION; TISSUE SPECIFICITY; TUMOR XENOGRAFT; ANIMAL; BRAIN; BRAIN TUMOR; C57BL MOUSE; CHEMISTRY; CONFORMATION; DRUG SCREENING; GLIOBLASTOMA; GLYCOSYLATION; MASS SPECTROMETRY; METABOLISM; MOLECULAR IMAGING; PROCEDURES; SCID MOUSE; TISSUE FIXATION;

ANIMALS; BRAIN; BRAIN NEOPLASMS; CARBOHYDRATE CONFORMATION; FORMALDEHYDE; GLIOBLASTOMA; GLYCOSYLATION; HUMANS; MALE; MICE, INBRED C57BL; MICE, SCID; MOLECULAR IMAGING; PARAFFIN EMBEDDING; PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL) ASPARAGINE AMIDASE; POLYSACCHARIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE FIXATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84912573847     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500405h     Document Type: Article

References (33)

1. Hart, G. W., and Copeland, R. J. (2010) Glycomics hits the big time. Cell 143, 672-6.
2. Walt, D., Aoki-Kinoshita, K. F., Bertozzi, C., Boons, G.-J., Darvill, A., Hart, G., Kiessling, L., Lowe, J., Moon, R. J., Paulson, J. C., Sasisekharan, R., Varki, A. P., and Wong, C.-H. (2012) Transforming Glycoscience: A Roadmap for the Future; The National Academies Press, Washington, DC.
3. Varki, A., Cummings, A. J., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. W., and Etzler, M. E. (2009) Essentials of glycobiology. Trends Cell Biol. (Varki, A., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. W., and Etzler, M. E., Eds.), p 752, Cold Spring Harbor Laboratory Press, New York.
4. Sharon, N., and Lis, H. (2003) Lectins, 2nd ed., Springer, Dordrecht.
5. Debray, H., Decout, D., Strecker, G., Spik, G., and Montreuil, J. (1981) Specificity of twelve lectins towards oligosaccharides and glycopeptides related to N-glycosylproteins. Fed. Eur. Biochem. Soc. J. 117, 41-55.
6. Stoeckli, M., Chaurand, P., Hallahan, D. E., and Caprioli, R. M. (2001) Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissues. Nat. Med. 7, 493-6.
7. Seeley, E. H., Oppenheimer, S. R., Mi, D., Chaurand, P., and Caprioli, R. M. (2008) Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections. J. Am. Soc. Mass Spectrom. 19, 1069-77.
8. Goto-Inoue, N., Hayasaka, T., Zaima, N., and Setou, M. (2011) Imaging mass spectrometry for lipidomics. Biochim. Biophys. Acta 1811, 961-9.
9. Cornett, D. S., Frappier, S. L., and Caprioli, R. M. (2008) MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue. Anal. Chem. 80, 5648-53.
10. Groseclose, M. R., Massion, P. P., Chaurand, P., and Caprioli, R. M. (2008) High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry. Proteomics 8, 3715-24.
11. Zaia, J. (2008) Mass spectrometry and the emerging field of glycomics. Chem. Biol. 15, 881-92.
12. Dell, a, Reason, a J., Khoo, K. H., Panico, M., McDowell, R. a, and Morris, H. R. (1994) Mass spectrometry of carbohydrate-containing biopolymers. Methods Enzymol. 230, 108-32.
13. Zaia, J. (2004) Mass spectrometry of oligosaccharides. Mass Spectrom. Rev. 23, 161-227.
14. Yang, S., Li, Y., Shah, P., and Zhang, H. (2013) Glycomic analysis using glycoprotein immobilization for glycan extraction. Anal. Chem. 85, 5555-61.
15. Yang, S., Eshghi, S. T., and Chiu, H. (2013) Glycomic analysis by glycoprotein immobilization for glycan extraction and liquid chromatography on microfluidic chip. Anal. Chem. 85, 10117-10125.
16. Ceroni, A., Maass, K., and Geyer, H. (2008) GlycoWorkbench: A tool for the computer-assisted annotation of mass spectra of glycans. J. Proteome Res. 7, 1650-1659.
17. Harvey, D. J. (1999) Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates. Mass Spectrom. Rev. 18, 349-450.
18. Wheeler, S. F., Domann, P., and Harvey, D. J. (2009) Derivatization of sialic acids for stabilization in matrix-assisted laser desorption/ionization mass spectrometry and concomitant differentiation of α(2 → 3)- and α(2 → 6)-isomers. Rapid Commun. Mass Spectrom. 23, 303-312.
19. Stumpo, K. A., and Reinhold, V. N. (2010) The N-glycome of human plasma. J. Proteome Res. 9, 4823-4830.
20. Aldredge, D., An, H. J., Tang, N., Waddell, K., and Lebrilla, C. B. (2012) Annotation of a serum N-glycan library for rapid identification of structures. J. Proteome Res. 11, 1958-68.
21. Hu, Y., Zhou, S., Khalil, S. I., Renteria, C. L., and Mechref, Y. (2013) Glycomic profiling of tissue sections by LC-MS. Anal. Chem. 85, 4074-4079.
22. Chen, Y. J., Wing, D. R., Guile, G. R., Dwek, R. a, Harvey, D. J., and Zamze, S. (1998) Neutral N-glycans in adult rat brain tissue - Complete characterisation reveals fucosylated hybrid and complex structures. Eur. J. Biochem. 251, 691-703.
23. Powers, T., and Jones, E. (2013) Matrix assisted laser desorption ionization imaging mass spectrometry workflow for spatial profiling analysis of N-linked glycan expression in tissues. Anal. Chem. 85, 9799-9806.
24. Toghi Eshghi, S., Li, X., and Zhang, H. (2012) Targeted analyte detection by standard addition improves detection limits in matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 84, 7626-32.
25. Shah, P., Yang, S., Sun, S., Aiyetan, P., Yarema, K. J., and Zhang, H. (2013) Mass spectrometric analysis of sialylated glycans with use of solid-phase labeling of sialic acids. Anal. Chem. 85, 3606-13.
26. Spraggins, J. M., and Caprioli, R. M. (2011) High-speed MALDI-TOF imaging mass spectrometry: Rapid ion image acquisition and considerations for next generation instrumentation. J. Am. Soc. Mass Spectrom. 22, 1022-31.
27. Klerk, L. a., Altelaar, a. F. M., Froesch, M., McDonnell, L. a., and Heeren, R. M. a. (2009) Fast and automated large-area imaging MALDI mass spectrometry in microprobe and microscope mode. Int. J. Mass Spectrom. 285, 19-25.
28. Aerni, H.-R., Cornett, D. S., and Caprioli, R. M. (2006) Automated acoustic matrix deposition for MALDI sample preparation. Anal. Chem. 78, 827-34.
29. Baluya, D. L., Garrett, T. J., and Yost, R. a. (2007) Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry. Anal. Chem. 79, 6862-7.
30. Franck, J., Arafah, K., Barnes, A., Wisztorski, M., Salzet, M., and Fournier, I. (2009) Improving tissue preparation for matrix-assisted laser desorption ionization mass spectrometry imaging. Part 1: Using microspotting. Anal. Chem. 81, 8193-202.
31. McDonnell, L. a, van Remoortere, A., van Zeijl, R. J. M., Dalebout, H., Bladergroen, M. R., and Deelder, A. M. (2010) Automated imaging MS: Toward high throughput imaging mass spectrometry. J. Proteomics 73, 1279-82.
32. Chaichana, K. L., Guerrero-cazares, H., Capilla-gonzalez, V., Zamora-berridi, G., Achanta, P., Gonzalez-perez, O., Jallo, G. I., Garcia-verdugo, J. M., and Qui, A. (2009) Intra-operatively obtained human tissue: Protocols and techniques for the study of neural stem cells. J. Neurosci. Methods 180, 116-125.
33. Garrett, T. J., Prieto-Conaway, M. C., Kovtoun, V., Bui, H., Izgarian, N., Stafford, G., and Yost, R. a. (2007) Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer. Int. J. Mass Spectrom. 260, 166-176.