Hidden structural features of multicompartment micelles revealed by cryogenic transmission electron tomography

ACS Nano

Volumn 8, Issue 11, 2014, Pages 11330-11340

  Löbling, Tina I ^a   Haataja, Johannes S ^b   Synatschke, Christopher V ^a   Schacher, Felix H ^c   Müller, Melanie ^a   Hanisch, Andreas ^a   Gröschel, André H ^b   Müller, Axel H E ^a,d  

^a UNIVERSITY OF BAYREUTH   (Germany)

^b AALTO UNIVERSITY   (Finland)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cryo electron tomography; Interpolyelectrolyte complexes; Multicompartment micelles; Nanoparticles; Self assembly

Indexed keywords

BLOCK COPOLYMERS; CRYOGENICS; ELECTRIC IMPEDANCE TOMOGRAPHY; GRAFTING (CHEMICAL); HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; NANOPARTICLES; SELF ASSEMBLY; TERPOLYMERS; TRANSMISSIONS;

CHARACTERIZATION TOOLS; COMPLEX NANOSTRUCTURES; CRYO-ELECTRON TOMOGRAPHY; CRYOGENIC TRANSMISSION ELECTRON MICROSCOPY (CRYO-TEM); INTERPOLYELECTROLYTE COMPLEX; MORPHOLOGICAL FEATURES; MULTICOMPARTMENT MICELLES; TRANSMISSION ELECTRON;

MICELLES;

MICELLE; POLYMER;

CHEMISTRY; ELECTRON TOMOGRAPHY; MICELLE; PROCEDURES; PROTON NUCLEAR MAGNETIC RESONANCE; SIZE EXCLUSION CHROMATOGRAPHY;

CHROMATOGRAPHY, GEL; ELECTRON MICROSCOPE TOMOGRAPHY; MICELLES; POLYMERS; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

EID: 84912573326     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn504197y     Document Type: Article

References (56)

1. Glotzer, S. C.; Solomon, M. J. Anisotropy of Building Blocks and Their Assembly into Complex Structures. Nat. Mater. 2007, 6, 557-562.
2. Walther, A.; Müller, A. H. E. Janus Particles: Synthesis, Self-Assembly, Physical Properties, and Applications. Chem. Rev. 2013, 113, 5194-5261.
3. Du, J.; O'Reilly, R. K. Anisotropic Particles with Patchy, Multicompartment and Janus Architectures: Preparation and Application. Chem. Soc. Rev. 2011, 40, 2402-2416.
4. Zhu, J.; Zhang, S.; Zhang, K.; Wang, X.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. Disk-Cylinder and Disk-Sphere Nanoparticles via a Block Copolymer Blend Solution Construction. Nat. Commun. 2013, 4, 2297.
5. Rupar, P. A.; Chabanne, L.; Winnik, M. A.; Manners, I. Non-Centrosymmetric Cylindrical Micelles by Unidirectional Growth. Science 2012, 337, 559-562.
6. Gröschel, A. H.; Schacher, F. H.; Schmalz, H.; Borisov, O. V.; Zhulina, E. B.; Walther, A.; Müller, A. H. E. Precise Hierarchical Self-Assembly of Multicompartment Micelles. Nat. Commun. 2012, 3, 710.
7. Moughton, A. O.; Hillmyer, M. A.; Lodge, T. P. Multicompartment Block Polymer Micelles. Macromolecules 2012, 45, 2-19.
8. Bates, F. S.; Hillmyer, M. A.; Lodge, T. P.; Bates, C. M.; Delaney, K. T.; Fredrickson, G. H. Multiblock Polymers: Panacea or Pandora's Box? Science 2012, 336, 434-440.
9. Wyman, I. W.; Liu, G. Micellar Structures of Linear Triblock Terpolymers: Three Blocks but Many Possibilities. Polymer 2013, 54, 1950-1978.
10. Zhang, L.; Yu, K.; Eisenberg, A. Ion-Induced Morphological Changes in "Crew-Cut" Aggregates of Amphiphilic Block Copolymers. Science 1996, 272, 1777-1779.
11. Förster, S.; Hermsdorf, N.; Böttcher, C.; Lindner, P. Structure of Polyelectrolyte Block Copolymer Micelles. Macromolecules 2002, 35, 4096-4105.
12. Pergushov, D. V.; Müller, A. H. E.; Schacher, F. H. Micellar Interpolyelectrolyte Complexes. Chem. Soc. Rev. 2012, 41, 6888-6901.
13. Sharma, G.; Mei, Y.; Lu, Y.; Ballauff, M.; Irrgang, T.; Proch, S.; Kempe, R. Spherical Polyelectrolyte Brushes as Carriers for Platinum Nanoparticles in Heterogeneous Hydrogenation Reactions. J. Catal. 2007, 246, 10-14.
14. Wittemann, A.; Haupt, B.; Ballauff, M. Adsorption of Proteins on Spherical Polyelectrolyte Brushes in Aqueous Solution. Phys. Chem. Chem. Phys. 2003, 5, 1671-1677.
15. Wittemann, A.; Ballauff, M. Interaction of Proteins with Linear Polyelectrolytes and Spherical Polyelectrolyte Brushes in Aqueous Solution. Phys. Chem. Chem. Phys. 2006, 8, 5269-5275.
16. Wang, S.; Chen, K.; Li, L.; Guo, X. Binding between Proteins and Cationic Spherical Polyelectrolyte Brushes: Effect of pH, Ionic Strength, and Stoichiometry. Biomacromolecules 2013, 14, 818-827.
17. Haupt, B.; Neumann, T.; Wittemann, A.; Ballauff, M. Activity of Enzymes Immobilized in Colloidal Spherical Polyelectrolyte Brushes. Biomacromolecules 2005, 6, 948-955.
18. Harada, A.; Kataoka, K. Chain Length Recognition: Core-Shell Supramolecular Assembly from Oppositely Charged Block Copolymers. Science 1999, 283, 65-67.
19. Gohy, J.-F.; Varshney, S. K.; Jérôme, R. Water-Soluble Complexes Formed by Poly(2-vinylpyridinium)-block-Poly-(ethylene oxide) and Poly(sodium methacrylate)-block-Poly(ethylene oxide) Copolymers. Macromolecules 2001, 34, 3361-3366.
20. Schacher, F.; Walther, A.; Müller, A. H. E. Dynamic Multi-compartment-Core Micelles in Aqueous Media. Langmuir 2009, 25, 10962-10969.
21. Schacher, F.; Betthausen, E.; Walther, A.; Schmalz, H.; Pergushov, D. V.; Müller, A. H. E. Interpolyelectrolyte Complexes of Dynamic Multicompartment Micelles. ACS Nano 2009, 3, 2095-2102.
22. Synatschke, C. V.; Schacher, F. H.; Förtsch, M.; Drechsler, M.; Müller, A. H. E. Double-Layered Micellar Interpolyelectrolyte Complexes - How Many Shells to a Core? Soft Matter 2011, 7, 1714-1725.
23. Synatschke, C. V.; Löbling, T. I.; Förtsch, M.; Hanisch, A.; Schacher, F. H.; Müller, A. H. E. Micellar Interpolyelectrolyte Complexes with a Compartmentalized Shell. Macromolecules 2013, 46, 6466-6474.
24. Kabanov, V. A. Polyelectrolyte Complexes in Solution and in Bulk. Russ. Chem. Rev. 2005, 74, 3-20.
25. Lefèvre, N.; Fustin, C.-A.; Gohy, J.-F. Polymeric Micelles Induced by Interpolymer Complexation. Macromol. Rapid Commun. 2009, 30, 1871-1888.
26. Pergushov, D. V.; Zezin, A. A.; Zezin, A. B.; Müller, A. H. E. Advanced Functional Structures Based on Interpolyelectrolyte Complexes. Adv. Polym. Sci. 2014, 255, 173-225.
27. Schrage, S.; Sigel, R.; Schlaad, H. Formation of Amphiphilic Polyion Complex Vesicles from Mixtures of Oppositely Charged Block Ionomers. Macromolecules 2003, 36, 2-5.
28. Plamper, F. A.; Gelissen, A. P.; Timper, J.; Wolf, A.; Zezin, A. B.; Richtering, W.; Tenhu, H.; Simon, U.; Mayer, J.; Borisov, O. V.; et al. Spontaneous Assembly of Miktoarm Stars into Vesicular Interpolyelectrolyte Complexes. Macromol. Rapid Commun. 2013, 34, 855-860.
29. Anraku, Y.; Kishimura, A.; Oba, M.; Yamasaki, Y.; Kataoka, K. Spontaneous Formation of Nanosized Unilamellar Polyion Complex Vesicles with Tunable Size and Properties. J. Am. Chem. Soc. 2010, 132, 1631-1636.
30. Voets, I. K.; Keizer, A.; De Waard, P.; De Frederik, P. M.; Bomans, P. H. H.; Schmalz, H.; Walther, A.; King, S. M.; Leermakers, F. A. M.; Stuart, M. A. C. Double-Faced Micelles from Water-Soluble Polymers. Angew. Chem., Int. Ed. 2006, 6673-6676.
31. Christian, D. A.; Tian, A.; Ellenbroek, W. G.; Levental, I.; Rajagopal, K.; Janmey, P. A.; Liu, A. J.; Baumgart, T.; Discher, D. E. Spotted Vesicles, StripedMicelles and Janus Assemblies Induced by Ligand Binding. Nat. Mater. 2009, 8, 843-849.
32. Synatschke, C. V.; Nomoto, T.; Cabral, H.; Förtsch, M.; Toh, K.; Matsumoto, Y.; Miyazaki, K.; Hanisch, A.; Schacher, F. H.; Kishimura, A.; et al. Multicompartment Micelles with Adjustable Poly(ethylene Glycol) Shell for Efficient in Vivo Photodynamic Therapy. ACS Nano 2014, 8, 1161-1172.
33. Larin, S. V.; Pergushov, D. V.; Xu, Y.; Darinskii, A. A.; Zezin, A. B.; Müller, A. H. E.; Borisov, O. V. Nano-Patterned Structures in Cylindrical Polyelectrolyte Brushes Assembled with Oppositely Charged Polyions. Soft Matter 2009, 5, 4938-4943.
34. Pons-Siepermann, I. C.; Glotzer, S. C. Design of Patchy Particles Using Quaternary Self-Assembled Monolayers. ACS Nano 2012, 6, 3919-3924.
35. Kostiainen, M. A.; Hiekkataipale, P.; Laiho, A.; Lemieux, V.; Seitsonen, J.; Ruokolainen, J.; Ceci, P. Electrostatic Assembly of Binary Nanoparticle Superlattices Using Protein Cages. Nat. Nanotechnol. 2013, 8, 52-56.
36. Chen, Q.; Diesel, E.; Whitmer, J. K.; Bae, S. C.; Luijten, E.; Granick, S. Triblock Colloids for Directed Self-Assembly. J. Am. Chem. Soc. 2011, 133, 7725-7727.
37. Chen, Q.; Bae, S. C.; Granick, S. Staged Self-Assembly of Colloidal Metastructures. J. Am. Chem. Soc. 2012, 134, 11080-11083.
38. Gröschel, A. H.; Walther, A.; Löbling, T. I.; Schmelz, J.; Hanisch, A.; Schmalz, H.; Müller, A. H. E. Facile, Solution-Based Synthesis of Soft, Nanoscale Janus Particles with Tunable Janus Balance. J. Am. Chem. Soc. 2012, 134, 13850-13860.
39. Wang, X.; Guerin, G.; Wang, H.; Wang, Y.; Manners, I.; Winnik, M. A. Cylindrical Block Copolymer Micelles and Co-Micelles of Controlled Length and Architecture. Science 2007, 317, 644-647.
40. Hudson, Z. M.; Lunn, D. J.; Winnik, M. A.; Manners, I. Colour-Tunable Fluorescent Multiblock Micelles. Nat. Commun. 2014, 5, 3372.
41. Schmelz, J.; Karg, M.; Hellweg, T.; Schmalz, H. General Pathway toward Crystalline-Core Micelles with Tunable Morphology and Corona Segregation. ACS Nano 2011, 5, 9523-9534.
42. Zhong, S.; Pochan, D. J. Cryogenic Transmission Electron Microscopy for Direct Observation of Polymer and Small-Molecule Materials and Structures in Solution. Polym. Rev. 2010, 50, 287-320.
43. Newcomb, C. J.; Moyer, T. J.; Lee, S. S.; Stupp, S. I. Advances in Cryogenic Transmission Electron Microscopy for the Characterization of Dynamic Self-Assembling Nanostructures. Curr. Opin. Colloid Interface Sci. 2012, 17, 350-359.
44. Nudelman, F.; With, G.; de Sommerdijk, N. A. J. M. Cryo-Electron Tomography: 3-Dimensional Imaging of Soft Matter. Soft Matter 2011, 7, 17-24.
45. Song, F.; Chen, P.; Sun, D.; Wang, M.; Dong, L.; Liang, D.; Xu, R.-M.; Zhu, P.; Li, G. Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units. Science 2014, 344, 376-380.
46. Majoinen, J.; Haataja, J. S.; Appelhans, D.; Lederer, A.; Olszewska, A.; Seitsonen, J.; Aseyev, V.; Kontturi, E.; Rosilo, H.; Österberg, M.; et al. Supracolloidal Multivalent Interactions and Wrapping of Dendronized Glycopolymers on Native Cellulose Nanocrystals. J. Am. Chem. Soc. 2014, 136, 866-869.
47. Nudelman, F.; Pieterse, K.; George, A.; Bomans, P. H. H.; Friedrich, H.; Brylka, L. J.; Hilbers, P. A. J.; With, G.; de Sommerdijk, N. A. J. M. The Role of Collagen in Bone Apatite Formation in the Presence of Hydroxyapatite Nucleation Inhibitors. Nat. Mater. 2010, 9, 1004-1009.
48. McKenzie, B. E.; Nudelman, F.; Bomans, P. H. H.; Holder, S. J.; Sommerdijk, N. A. J. M. Temperature-Responsive Nanospheres with Bicontinuous Internal Structures from a Semicrystalline Amphiphilic Block Copolymer. J. Am. Chem. Soc. 2010, 132, 10256-10259.
49. Parry, A. L.; Bomans, P. H. H.; Holder, S. J.; Sommerdijk, N. A. J. M.; Biagini, S. C. G. Cryo Electron Tomography Reveals Confined Complex Morphologies of Tripeptide-Containing Amphiphilic Double-Comb Diblock Copolymers. Angew. Chem., Int. Ed. 2008, 47, 8859-8862.
50. Hanisch, A.; Förtsch, M.; Drechsler, M.; Jinnai, H.; Ruhland, T. M.; Schacher, F. H.; Müller, A. H. E. Counterion-Mediated Hierarchical Self-Assembly of an ABC Miktoarm Star Terpolymer. ACS Nano 2013, 7, 4030-4041.
51. Dupont, J.; Liu, G.; Niihara, K.; Kimoto, R.; Jinnai, H. Self-Assembled ABC Triblock Copolymer Double and Triple Helices. Angew. Chem., Int. Ed. 2009, 48, 6144-6147.
52. Hickey, R. J.; Koski, J.; Meng, X.; Riggleman, R. A.; Zhang, P.; Park, S.-J. Size-Controlled Self-Assembly of Superparamagnetic Polymersomes. ACS Nano 2014, 8, 495-502.
53. Jinnai, H.; Spontak, R. J.; Nishi, T. Transmission Electron Microtomography and Polymer Nanostructures. Macromolecules 2010, 43, 1675-1688.
54. Hermans, T. M.; Broeren, M. A. C.; Gomopoulos, N.; Schoot, P.; van der Genderen, M. H. P.; van Sommerdijk, N. A. J. M.; Fytas, G.; Meijer, E. W. Self-Assembly of Soft Nanoparticles with Tunable Patchiness. Nat. Nanotechnol. 2009, 4, 721-726.
55. Zhang, L.; Wang, L.; Lin, J. Defect Structures and Ordering Behaviours of Diblock Copolymers Self-Assembling on Spherical Substrates. Soft Matter 2014, 10, 6713-6721.
56. Schacher, F.; Yuan, J.; Schoberth, H. G.; Müller, A. H. E. Synthesis, Characterization, and Bulk Crosslinking of Poly-butadiene-block-Poly(2-vinyl pyridine)-block-Poly(tert-butyl methacrylate) Block Terpolymers. Polymer 2010, 51, 2021-2032.