Cryo electron tomography reveals confined complex morphologies of tripeptide-containing amphiphilic double-comb diblock copolymers

Angewandte Chemie - International Edition

Volumn 47, Issue 46, 2008, Pages 8859-8862

  Parry, Alison L ^a   Bomans, Paul H H ^b   Holder, Simon J ^a   Sommerdijk, Nico A J M ^b   Biagini, Stefano C G ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Aggregation; Branching; Electron microscopy; Polynorbornene; Self assembly

Indexed keywords

AMINES; AMINO ACIDS; CHEMICAL REACTIONS; COLLOIDS; DIAGNOSTIC RADIOGRAPHY; ELECTRIC IMPEDANCE TOMOGRAPHY; ETHYLENE; MEDICAL IMAGING; ORGANIC ACIDS; POLYMERS; TOMOGRAPHY;

AGGREGATION; AMINO ACID SEQUENCES; AMPHIPHILIC; BICONTINUOUS; BRANCHING; CHEMICAL EQUATIONS; COMPLEX MORPHOLOGIES; DIBLOCK COPOLYMERS; DIBLOCK POLYMERS; ELECTRON TOMOGRAPHIES; ETHYLENE OXIDES; HIGHLY BRANCHED; INTERNAL STRUCTURES; NORBORNENE; POLYNORBORNENE; SELF-ASSEMBLY; SEQUENCE SETS; SIDE CHAINS; SPHERICAL AGGREGATES; TRI PEPTIDES; WORMLIKE MICELLES;

AGGREGATES;

PEPTIDE; POLYMER; WATER;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CRYOELECTRON MICROSCOPY; HYDROPHOBICITY; TRANSMISSION ELECTRON MICROSCOPY;

CRYOELECTRON MICROSCOPY; HYDROPHOBICITY; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; PEPTIDES; POLYMERS; WATER;

EID: 57349108218     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200802834     Document Type: Article

References (38)

1. a) D. E. Discher, A. Eisenberg, Science 2002, 297, 967-973;
2. b) M. Antonietti, S. FFrster, Adv. Mater. 2003, 15, 1323-1333.
3. Z. Li, E. Kesselman, Y. Talmon, M. A. Hillmyer, T. P. Lodge, Science 2004, 306, 98-101.
4. D. J. Pochan, Z. Chen, H. Cui, . K. Hales, K. Qi, K. L. Wooley, Science 2004, 306, 94-97.
5. L. Zhang, C. Bartels, Y. Yu, H. Shen, A. Eisenberg, Phys. Rev. Lett. 1997, 79, 5034-5037.
6. J. J. L. M. Cornelissen, M. Fischer, N. A. J. M. Sommerdijk, R. J. M. Nolte, Science 1998, 280, 1427-1430.
7. S. Jain, F. S. Bates, Science 2003, 300, 460-464.
8. a) J. C. M. van Hest, D. A. P. Delnoye, M. W. P. L. Baars, M. H. P. van Genderen, E. W. Meijer, Science 1995, 268, 1592;
9. b) I. Gitsov, J. M. J. Fréchet, J. Am. Chem. Soc. 1996, 118, 3785-3786.
10. a) R. Matmour, R. Francis, R. S. Duran, Y. Gnanou, Macromolecules 2005, 38, 7754-7767;
11. b) A. Heise, J. L. Hedrick, C. W. Frank, R. D. Miller, J. Am. Chem. Soc. 1999, 121, 8647-8648.
12. a) J. Grumelard, A. Taubert, W. Meier, Chem. Commun. 2004, 1462- 1463;
13. b) N. Chebotareva, P. H. H. Bomans, P. M. Frederik, N. A. J. M. Sommerdijk, R. P. Sijbesma, Chem. Commun. 2005, 4967-4969.
14. Z. Li, E. Kesselman, Y. Talmon, M. A. Hillmyer, T. P. Lodge, Science 2004, 306, 98-101;
15. H. Cui, Z. Chen, S. Zhong, K. L. Wooley, D. J. Pochan, Science 2007, 317, 647-650.
16. a) S. J. Holder, R. C. Hiorns, N. A. J. M. Sommerdijk, R. G. Jones, R. J. M. Nolte, Chem. Commun. 1998, 1445;
17. b) N. A. J. M. Sommerdijk, S. J. Holder, R. C. Hiorns, R. G. Jones, R. J. M. Nolte, Macromolecules 2000, 33, 8289-8294.
18. G. W. M. Vandermeulen, K. T. Kim, Z. Wang, I. Manners, Biomacromolecules 2006, 7, 1005-1010.
19. H. D. Maynard, S. Y. Okada, R. H. Grubbs, J. Am. Chem. Soc. 2001, 123, 1275-1279.
20. N. B. Holland, Y. Qiu, M. Ruegsegger, R. E. Marchant, Nature 1998, 392, 799-801.
21. S. C. G. Biagini, A. L. Parry, J. Polym. Sci. Part A 2007, 45, 3178-3190.
22. a) P. M. Frederik, N. A. J. M. Sommerdijk, Curr. Opin. Colloid Interface Sci. 2005, 10, 245;
23. b) H. Cui, T. K. Hodgdon, E. W. Kaler, L. Abezgauz, D. Danino, M. Lubovsky, Y. Talmon, D. J. Pochan, Soft Matter 2007, 3, 945-955.
24. a) S. Nickell, C. Kofler, A. P. Leis, W. Baumeister, Nat. Rev. Mol. Cell Biol. 2006, 7, 225-230;
25. b) P. A. Midgley, P. E. P. W. Ward, A. B. Hungria, J. M. Thomas, Chem. Soc. Rev. 2007, 36, 1477-1494.
26. a) M. R. J. Vos, P. H. H. Bomans, F. de Haas, P. M. Frederik, J. A. Jansen, R. J. M. Nolte N. A. J. M. Sommerdijk, J. Am. Chem. Soc. 2007, 129, 11894;
27. b) T. M. Hermans, M. A. C Broeren, N. Gomopoulos, A. F. Smeijers, B. Mezari, E. N. M. van Leeuwen, M. R. J. Vos, P. C. M. M. Magusin, P. A. J. Hilbers, M. H. P. van Genderen, N. A. J. M. Sommerdijk, G. Fytas, E. W. Meijer, J. Am. Chem. Soc. 2007, 129, 15631.
28. a) S. Han, M. Hagiwara, T. Ishizone, Macromolecules 2003, 36, 8312- 8319;
29. b) J. F. Lutz, A Hoth, Macromolecules 2006, 39, 893-896.
30. a) J. Godward, F. Heatley, C. Price, J. Chem. Soc. Faraday Trans. 1993, 89, 3471-3475;
31. b) F. Cau, S. Lacelle, Macromolecules 1996, 29, 170-178;
32. c) J. Křĩž, B. Masař, H. Pospĩž il, J. PleŠtil, Z. Tuzar, M. A. Kiselev, Macromolecules 1996, 29, 7853-7858.
33. The presence of both cis and trans double bonds (ratio 15:85) may be of some importance to the folding properties of the PN back bone, but no further evidence to support this suggestion is available at the moment.
34. a) S. A. Safran, Surf. Sci. 2002, 500 127-146;
35. b) S. Jain, F. S. Bates, Macromolecules 2004, 37, 1511-1523.
36. Objects with similar appearance (in projection) have been observed by Eisenberg and co-workers upon addition of NaCl to vesicles of polystyrene-polyacrylic acid block copolymers; however, detailed TEM investigations of these structures under different tilt angles revealed that these intermediates were dissimilar to the structures observed in the present study: K. Yu, C. Bartels, A. Eisenberg, Langmuir 1999, 15, 7157-7167.
37. J. G. E. M. Fraaije, G. J. A. Sevink, Macromolecules 2003, 36, 7891.
38. Ref. [24] also predicted the formation of globules of closely associated of spherical micelles. These aggregates strongly resemble the clusters of micelles observed for PNOEG-PNGGG. However, because of the absence of detailed 3D morphological data, we cannot further confirm the structural resemblance between the two structures.