Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 47, 2014, Pages E5039-E5048

  Umemura, Yasuhiro ^a   Koike, Nobuya ^a   Matsumoto, Tsuguhiro ^a   Yoo, Seung Hee ^b   Chen, Zheng ^b   Yasuhara, Noriko ^c   Takahashi, Joseph S ^d,e   Yagita, Kazuhiro ^a,f  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

C Myc; Cellular differentiation; Circadian clock; Dnmt1; Kpna2 (Importin 2)

Indexed keywords

DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; IMPORTIN ALPHA2; KARYOPHERIN ALPHA; MYC PROTEIN; PER1 PROTEIN; PER2 PROTEIN; UNCLASSIFIED DRUG; KPNA2 PROTEIN, MOUSE; NUCLEAR PROTEIN;

ANIMAL CELL; ARTICLE; BIOLUMINESCENCE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; IMMUNOFLUORESCENCE; MAMMAL CELL; MOUSE; NONHUMAN; RNA SEQUENCE; SINGLE CELL ANALYSIS; STABLE EXPRESSION; ANIMAL; CYTOLOGY; GENETIC EPIGENESIS; GENETICS; PHYSIOLOGY;

MAMMALIA;

ANIMALS; CELL DIFFERENTIATION; CIRCADIAN CLOCKS; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; MICE; NUCLEAR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84912569226     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419272111     Document Type: Article

References (38)

1. Lowrey PL, Takahashi JS (2011) Genetics of circadian rhythms in Mammalian model organisms. Adv Genet 74:175-230.
2. Bass J (2012) Circadian topology of metabolism. Nature 491(7424):348-356.
3. Masri S, Sassone-Corsi P (2013) The circadian clock: A framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci 14(1):69-75.
4. King DP, et al. (1997) Positional cloning of the mouse circadian clock gene. Cell 89(4): 641-653.
5. Gekakis N, et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280(5369):1564-1569.
6. Kume K, et al. (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98(2):193-205.
7. Griffin EA, Jr, Staknis D, Weitz CJ (1999) Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science 286(5440):768-771.
8. Yagita K, Tamanini F, van Der Horst GT, Okamura H (2001) Molecular mechanisms of the biological clock in cultured fibroblasts. Science 292(5515):278-281.
9. Yagita K, et al. (2002) Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein. EMBO J 21(6):1301-1314.
10. Preitner N, et al. (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110(2):251-260.
11. Ukai-Tadenuma M, et al. (2011) Delay in feedback repression by cryptochrome 1. is required for circadian clock function. Cell 144(2):268-281.
12. Reppert SM, Schwartz WJ (1986) Maternal suprachiasmatic nuclei are necessary for maternal coordination of the developing circadian system. J Neurosci 6(9):2724-2729.
13. Davis FC, Gorski RA (1988) Development of hamster circadian rhythms: Role of the maternal suprachiasmatic nucleus. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 162(5):601-610.
14. Amano T, et al. (2009) Expression and functional analyses of circadian genes in mouse oocytes and preimplantation embryos: Cry1 is involved in the meiotic process independently of circadian clock regulation. Biol Reprod 80(3):473-483.
15. Yagita K, et al. (2010) Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro. Proc Natl Acad Sci USA 107(8):3846-3851.
16. Kowalska E, Moriggi E, Bauer C, Dibner C, Brown SA (2010) The circadian clock starts ticking at a developmentally early stage. J Biol Rhythms 25(6):442-449.
17. Umemura Y, et al. (2013) An in vitro ES cell-based clock recapitulation assay model identifies CK2α as an endogenous clock regulator. PLoS ONE 8(6):e67241.
18. Ben-Porath I, et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40(5):499-507.
19. Mikkelsen TS, et al. (2008) Dissecting direct reprogramming through integrative genomic analysis. Nature 454(7200):49-55.
20. Hikichi T, et al. (2013) Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles. Proc Natl Acad Sci USA 110(16):6412-6417.
21. Lee TI, Young RA (2013) Transcriptional regulation and its misregulation in disease. Cell 152(6):1237-1251.
22. Ohnishi K, et al. (2014) Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell 156(4):663-677.
23. Chen Z, et al. (2012) Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc Natl Acad Sci USA 109(1):101-106.
24. Yoo SH, et al. (2004) PERIOD2:LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA 101(15):5339-5346.
25. Kim J, et al. (2010) A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 143(2):313-324.
26. Rahl PB, et al. (2010) c-Myc regulates transcriptional pause release. Cell 141(3): 432-445.
27. Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99(3):247-257.
28. Sakaue M, et al. (2010) DNA methylation is dispensable for the growth and survival of the extraembryonic lineages. Curr Biol 20(16):1452-1457.
29. Yasuhara N, et al. (2007) Triggering neural differentiation of ES cells by subtype switching of importin-alpha. Nat Cell Biol 9(1):72-79.
30. Yasuhara N, et al. (2013) Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance. Dev Cell 26(2):123-135.
31. Holmberg J, Perlmann T (2012) Maintaining differentiated cellular identity. Nat Rev Genet 13(6):429-439.
32. Levens DL (2003) Reconstructing MYC. Genes Dev 17(9):1071-1077.
33. Kondratov RV, Shamanna RK, Kondratova AA, Gorbacheva VY, AntochMP (2006) Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation. FASEB J 20(3):530-532.
34. Azzi A, et al. (2014) Circadian behavior is light-reprogrammed by plastic DNA methylation. Nat Neurosci 17(3):377-382.
35. van der Horst GT, et al. (1999) Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 398(6728):627-630.
36. Yagita K, et al. (2000) Dimerization and nuclear entry of mPER proteins in mammalian cells. Genes Dev 14(11):1353-1363.
37. Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418(6901):935-941.
38. Lei H, et al. (1996) De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122(10):3195-3205.