Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode

ACS Chemical Biology

Volumn 9, Issue 9, 2014, Pages 2023-2031

  Lu, Jun ^a   Patel, Sangita ^a   Sharma, Nandini ^a   Soisson, Stephen M ^a   Kishii, Ryuta ^b   Takei, Masaya ^b   Fukuda, Yasumichi ^b   Lumb, Kevin J ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; COUMARIN DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING) B; KIBDELOMYCIN; NOVOBIOCIN; PROTEIN PARE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG; 2 PYRROLIDONE DERIVATIVE; AMINOGLYCOSIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; DNA TOPOISOMERASE IV; GYRASE INHIBITOR; KIBDELOMYCIN A; NAPHTHALENE DERIVATIVE; PYRROLE DERIVATIVE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CROSS RESISTANCE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; HYDROGEN BOND; STAPHYLOCOCCUS AUREUS; SURFACE PROPERTY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; X RAY CRYSTALLOGRAPHY;

STAPHYLOCOCCUS AUREUS;

AMINOGLYCOSIDES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA GYRASE; DNA TOPOISOMERASE IV; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; NOVOBIOCIN; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PYRROLES; PYRROLIDINONES; STAPHYLOCOCCUS AUREUS; TOPOISOMERASE II INHIBITORS; TOPOISOMERASE INHIBITORS;

EID: 84912128221     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb5001197     Document Type: Article

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