Neuropathological staging of spinocerebellar ataxia type 2 by semiquantitative 1c2-positive neuron typing. Nuclear translocation of cytoplasmic 1C2 underlies disease progression of spinocerebellar ataxia type 2

Brain Pathology

Volumn 24, Issue 6, 2014, Pages 599-606

  Koyano, Shigeru ^a,d   Yagishita, Saburo ^b   Kuroiwa, Yoshiyuki ^c   Tanaka, Fumiaki ^a   Uchihara, Toshiki ^d  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KANAGAWA REHABILITATION CENTER   (Japan)

^c TEIKYO UNIVERSITY MIZONOKUCHI HOSPITAL   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

1C2 immunoreactive typing; cytoplasmic and nuclear; granular cytoplasmic; nuclear with inclusions; spinocerebellar ataxia type 2

Indexed keywords

ATAXIN 2; BRAIN PROTEIN; MUTANT PROTEIN; POLYGLUTAMINE; TRINUCLEOTIDE; UBIQUITIN; UNCLASSIFIED DRUG; NERVE PROTEIN; PEPTIDE; SCA2 PROTEIN;

ARTICLE; AUTOPSY; BRAIN REGION; CAG REPEAT; CELL LOSS; CELL NUCLEUS; CYTOPLASM; DISEASE COURSE; GENE PRODUCT; GLIOSIS; HUMAN; HUMAN TISSUE; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; NEUROPATHOLOGY; NUCLEAR LOCALIZATION SIGNAL; SPINOCEREBELLAR ATAXIA TYPE 2; SPINOCEREBELLAR DEGENERATION; ADULT; AGED; ATROPHY; BRAIN; CELL NUCLEUS INCLUSION BODY; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ATROPHY; BRAIN; CELL NUCLEUS; CYTOPLASM; DISEASE PROGRESSION; FEMALE; GLIOSIS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRANUCLEAR INCLUSION BODIES; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEURONS; PEPTIDES; SPINOCEREBELLAR ATAXIAS; UBIQUITIN;

EID: 84912118712     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12146     Document Type: Article

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