Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCα-p38-SP-1 pathway

FASEB Journal

Volumn 28, Issue 11, 2014, Pages 4591-4609

  Zhang, Pu ^a,b   Goodrich, Chris ^a   Fu, Changliang ^a   Dong, Cheng ^a  

^a The Pennsylvania State University   (United States)

^b WUXI APPTEC   (China)

Author keywords

Adhesion; Cross linkingcytokine; Flow coculture; Intracellular signaling

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GROWTH RELATED ONCOGENE ALPHA; HERMES ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; PROTEIN; PROTEIN KINASE C ALPHA; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR SP; UNCLASSIFIED DRUG; CD44 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR SP1;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; CROSS LINKING; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; MECHANOTRANSDUCTION; MELANOMA; MELANOMA CELL LINE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING; CELL COMMUNICATION; CELL CULTURE; CELL LINE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANTIGENS, CD44; CELL COMMUNICATION; CELL LINE; CELLS, CULTURED; E-SELECTIN; ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MELANOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C-ALPHA; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84912115871     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-202747     Document Type: Article

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