Effect of Iron Supplementation on the Expression of Hypoxia-Inducible Factor and Antioxidant Status in Rats Exposed to High-Altitude Hypoxia Environment

Biological Trace Element Research

Volumn 162, Issue 1-3, 2014, Pages 142-152

  Xu, Chunlan ^a   Dong, Chen ^a   Xu, Cuicui ^a   Han, Tiaotiao ^a   Bao, Sheng ^a   Gao, Xiaobo ^a  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

Author keywords

Ferrous sulfate; High altitude hypoxia; Hypoxia inducible factor 1 alpha; Iron; Iron glycine chelate

Indexed keywords

ANTIOXIDANT; CATALASE; ERYTHROPOIETIN; FERROUS SULFATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON DERIVATIVE; IRON GLYCINATE CHELATE; LIVER ENZYME; MALONALDEHYDE; MESSENGER RNA; SUPEROXIDE DISMUTASE; TRANSFERRIN; UNCLASSIFIED DRUG; FERROUS ION;

ALTITUDE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; BODY WEIGHT DISORDER; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; EPO GENE; ERYTHROPOIETIN BLOOD LEVEL; EXPLORATORY RESEARCH; GENE EXPRESSION REGULATION; GENE TARGETING; HEPATOMEGALY; HORMONE BLOOD LEVEL; HYPOBARISM; INTESTINE INJURY; INTESTINE MUCOSA; IRON THERAPY; LIVER LEVEL; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SPLEEN DISEASE; TISSUE INJURY; TRANSFERRIN GENE; UPREGULATION; WEIGHT REDUCTION; ALTITUDE; ANIMAL; ANOXIA; BLOOD; GENETICS; IMMUNOHISTOCHEMISTRY; LIVER; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

ALTITUDE; ANIMALS; ANOXIA; ANTIOXIDANTS; ERYTHROPOIETIN; FERROUS COMPOUNDS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MALONDIALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSFERRIN;

EID: 84912112620     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-014-0166-6     Document Type: Article

References (50)

1. Sherpa LY, Stigum H, Chongsuvivatwong V, Thelle DS, Bjertness E (2010) Obesity in Tibetans aged 30–70 living at different altitudes under the north and south faces of Mt. Everest. Int J Environ Res Public Health 7:1670–1680
2. Windsor JS, Rodway GW (2007) Heights and haematology: the story of haemoglobin at altitude. Postgrad Med J 83:148–151
3. Peyssonnaux C, Nizet V, Johnson RS (2008) Role of the hypoxia inducible factors in iron metabolism. Cell Cycle 7:28–32
4. Taylor DM, Vassar PS (1956) Effects of hypoxia on iron absorption in rats. Proc Soc Exp Biol Med 93:504–506
5. Krantz S, Goldwasser E, Jacobson LO (1959) Studies on erythropoiesis. XIV. The relationship of humoral stimulation to iron absorption. Blood 14:654–661
6. Strohmeyer GW, Miller SA, Scarlata RW, Moore EW, Greenberg MS, Chalmers TC (1964) Effects of hypoxia on iron absorption and mobilization in the rat. Am J Physiol 207:55–61
7. Reynafarje C, Lozano R, Valdivieso J (1959) The polycythemia of high altitudes: iron metabolism and related aspects. Blood 14:433–455
8. Abou-Zeid AH, Abdel-Fattah MM, AI-Shehri AS, Hifnawy TM, AI-Hassan SA (2006) Anemia and nutritional status of schoolchildren living at Saudi high altitude area. Saudi Med J 27:862–869
9. Salama SA, Omar HA, Maghrabi IA, AISaeed MS, EL-Tarras AE (2014) Iron supplementation at high altitudes induces inflammation and oxidative injury to lung tissues in rats. Toxicol Appl Pharm 274:1–6
10. Henry PR, Miller ER (1995) Iron availability. In: Ammerman CB, Baker DH, Lewis AS (eds) Bioavailability of nutrients for animals. Academic, San Diego, pp 169–199
11. Giorgini E, Fisberg M, Paula RA, Ferreira AM, Valle J, Braga JA (2001) The use of sweet rolls fortified with iron bisglycinate chelate in the prevention of iron deficiency anemia in preschool children. Arch Latinoam Nutr 51:48–53
12. Chepelev NL, Willmore WG (2011) Regulation of iron pathways in response to hypoxia. Free Radic Biol Med 50:645–666
13. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Johnson RS (2007) Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 117:1926–1932
14. Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ (2009) Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab 9:152–164
15. Lee DW, Andersen JK (2006) Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders. Curr Mol Med 6:883–893
16. Leung PS, Srai SK, Mascarenhas M, Churchill LJ, Debnam ES (2005) Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression. Gut 54:1391–1395
17. Hershko C, Link G, Pinson A (1987) Modification of iron uptake and lipid peroxidation by hypoxia, ascorbic acid, and α-tocopherol in iron-loaded rat myocardial cell cultures. J Lab Clin Med 110:355–361
18. Merle U, Fein E, Gehrke SG, Stremmel W, Kulaksiz H (2007) The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinol 148:2663–2668
19. Galaris D, Pantopoulos K (2008) Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Lab Sci 45:1–23
20. Mendes JF, Arruda SF, Siqueira EM, Ito MK, Silva EF (2009) Iron status and oxidative stress biomarkers in adults: a preliminary study. Nutrition 25:379–384
21. Rouault TA, Klausner RD (1996) Iron-sulfur clusters as biosensors of oxidants and iron. Trends Biochem Sci 21:174–177
22. Gutteridge JMC, Rowley DA, Halliwell B (1982) Superoxide-dependent formation of hydroxyl radical and lipid peroxidation in the presence of iron salt: detection of catalytic iron and antioxidant activity in extracellular fluids. J Biochem 206:605–609
23. Carine F, Valerie M, David D, Monique B, Jean-Claude B, Genevieve S, Annick P (1999) Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment. Mol Brain Res 72:183–194
24. Xu CL, Sun R, Qiao XJ, Xu CC, Shang XY, Niu WN (2014) Protective effect of glutamine on intestinal injury and bacterial community in rats exposed to hypobaric hypoxia environment. World J Gastroenterol 20:4662–4674
25. Mena S, Ortega A, Estrela JM (2009) Oxidative stress in environment-induced carcinogenesis. Mutat Res 674:36–44
26. Dosek A, Ohno H, Acs Z, Taylor AW, Radak Z (2007) High altitude and oxidative stress. Respir Physiol Neurobiol 158:128–131.27
27. Devi SA, Vani R, Subramanyam MVV, Reddy SS, Jeevaratnam K (2007) Intermittent hypobaric hypoxia-induced oxidative stress in rat erythrocytes: protective effects of vitamin E, vitamin C, and carnitine. Cell Biochem Funct 25:221–231
28. Udayabanu M, Kumaran D, Nair RU, Srinivas P, Bhagat N, Aneja R, Katyal A (2008) Nitric oxide associated with iNOS expression inhibits acetylcholinesterase activity and induces memory impairment during acute hypobaric hypoxia. Brain Res 1230:138–149
29. Maiti P, Singh SB, Sharma AK, Muthuraju S, Banerjee PK, Ilavazhagan G (2006) Hypobaric hypoxia induces oxidative stress in rat brain. Neurochem Int 49:709–716
30. Uzun FG, Demir F, Kalender S, Bas H, Kalender Y (2010) Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats. Food Chem Toxicol 48:1714–1720
31. Simpson RJ (1996) Dietary iron levels and hypoxia independently affect iron absorption in mice. J Nutr 126:1858–1864
32. Grocott MP, Martin DS, Levett DZ, McMorrow R, Windsor J, Montgomery HE (2009) Arterial blood gases and oxygen content in climbers on Mount Everest. N Engl J Med 360:140–149
33. Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Haase VH (2007) Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 117:1068–1077
34. Vigano A, Ripamonti M, De Palma S, Capitanio D, Vasso M, Wait R, Gelfi C (2008) Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia. Proteomics 8:4668–4679
35. Hamlin MJ, Marshall HC, Hellemans J, Ainslie PN, Anglem N (2010) Effect of intermittent hypoxic training on 20 km time trial and 30 s anaerobic performance. Scand J Med Sci Sports 20:651–661
36. Diez-Caballero F, Castilla-Cortázar I, Garcia-Fernandez M, Puche JE, Diaz-Sanchez M, Casares AD, Gonzalez-Barón S (2006) Little effects of insulin-like growth factor-I on testicular atrophy induced by hypoxia. BMC Urol 6:4
37. Ge RL, Witkowski S, Zhang Y, Alfrey C, Sivieri M, Karlsen T, Levine BD (2002) Determinants of erythropoietin release in response to short-term hypobaric hypoxia. J Appl Physiol 92:2361–2367
38. Beall CM, Decker MJ, Brittenham GM, Kushner I, Gebremedhin A, Strohl KP (2002) An Ethiopian pattern of human adaptation to high-altitude hypoxia. PNAS 99:17215–17218
39. Savourey G, Launay JC, Besnard Y, Guinet A, Bourrilhon C, Cabane D, Cottet-Emard JM (2004) Control of erythropoiesis after high altitude acclimatization. Eur J Appl Physiol 93:47–56
40. 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551–578
41. Basu M, Malhotra AS, Pal K, Prasad R, Kumar R, Prasad BA, Sawhney RC (2007) Erythropoietin levels in lowlanders and high altitude natives at 3450 m. Aviat Space Environ Med 78:963–967
42. Fedele AO, Whitelaw ML, Peet DJ (2002) Regulation of gene expression by the hypoxia-inducible factors. Mol Interv 2:229–243
43. Höpfl G, Ogunshola O, Gassmann M (2003) Hypoxia and high altitude. The molecular response. Adv Exp Med Biol 543:89–115
44. Zamudio S, Wu Y, Ietta F, Rolfo A, Cross A, Wheeler T, Post M, Illsley NP, Caniggia I (2007) Human placental hypoxia-inducible factor-1 alpha expression correlates with clinical outcomes in chronic hypoxia in vivo. Am J Pathol 170:2171–2179
45. Semenza GL (2009) Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology 24:97–106
46. Fang CL, Zhuo Z, Fang SL, Yue M, Feng J (2013) Iron sources on iron status and gene expression of iron related transporters in iron-deficient piglets. Anim Feed Sci Technol 182:121–125
47. Tapiero H, Gate L, Tew KD (2001) Iron: deficiencies and requirements. Biomed Pharmacother 55:324–332
48. Pineda O, Ashmead HD (2001) Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition 17:381–384
49. Mimura ÉCM, Breganó JW, Dichi JB, Gregório EP, Dichi I (2008) Comparison of ferrous sulfate and ferrous glycinate chelate for the treatment of iron deficiency anemia in gastrectomized patients. Nutrition 24:663–668
50. da Silva LF, Dutra-de-Oliveira JE, Marchini JS (2004) Serum iron analysis of adults receiving three different iron compounds. Nutr Res 24:603–611