Inhalation and oral toxicokinetics of 6:2 FTOH and its metabolites in mammals

Chemosphere

Volumn 120, Issue , 2015, Pages 328-335

  Russell, Mark H ^a   Himmelstein, Matthew W ^a   Buck, Robert C ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Fluorotelomer; Human; Inhalation; Kinetics; Oral; Rat

Indexed keywords

BIOMOLECULES; ENZYME KINETICS; METABOLISM; RATING; RATS;

6:2 FLUOROTELOMER ALCOHOL (6:2 FTOH); BIOMONITORING STUDIES; FLUOROTELOMER; HUMAN; INHALATION; ORAL; PLASMA CONCENTRATION; SERUM CONCENTRATION;

METABOLITES;

ALCOHOL; FLUOROTELOMER ALCOHOL; PERFLUORO COMPOUND; UNCLASSIFIED DRUG; FLUOROCARBON;

BIOMONITORING; CONCENTRATION (COMPOSITION); ESTIMATION METHOD; MAMMAL; METABOLISM; PLASMA; SERUM; TOXICOLOGY; WAX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MONITORING; BLOOD LEVEL; CONTROLLED STUDY; ELIMINATION HALF-LIFE; EXPOSURE; FEMALE; HUMAN; HUMAN CELL; INHALATION; LIVER CELL; MALE; MOUSE; NONHUMAN; OCCUPATIONAL EXPOSURE; RAT; TOXICOKINETICS; ANIMAL; DRUG EFFECTS; HALF LIFE TIME; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; ORAL DRUG ADMINISTRATION;

MAMMALIA; RATTUS;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; FEMALE; FLUOROCARBONS; HALF-LIFE; HEPATOCYTES; HUMANS; MALE; RATS; TOXICOKINETICS;

EID: 84912104892     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2014.07.092     Document Type: Article

References (37)

1. Ahrens L., Shoeib M., Del Vento S., Codling G., Halsall C. Polyfluoroalkyl compounds in the Canadian Arctic atmosphere. Environ. Chem. 2011, 8:399-406.
2. Ahrens L., Shoeib M., Harner T., Lee S.C., Guo R., Reiner E.J. Wastewater treatment plant and landfills as sources of polyfluoroalkyl compounds to the atmosphere. Environ. Sci. Technol. 2011, 45:8098-8105.
3. Ahrens L., Harner T., Shoeib M., Lane D.A., Murphy J.G. Improved characterization of gas-particle partitioning for per- and polyfluoroalkyl substances in the atmosphere using annular diffusion denuder samplers. Environ. Sci. Technol. 2012, 46:7199-7206.
4. Barber J.L., Berger U., Chaemfa C., Huber S., Jahnke A., Temme C., Jones K.C. Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe. J. Environ. Monit. 2007, 9:530-541.
5. Brown R.P., Delp M.D., Lindstedt S.L., Rhomberg L.R., Beliles R.P. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 1997, 13:407-484.
6. Buck R.C., Franklin J., Berger U., Conder J.M., Cousins I.T., de Voogt P., Jensen A.A., Kannan K., Mabury S.A., van Leeuwen S.P.J. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integrated Environ. Assess. Manage. 2011, 7:513-541.
7. Butt C.M., Muir D.C., Mabury S.A. Biotransformation pathways of fluorotelomer-based polyfluoroalkyl substances: a review. Environ. Toxicol. Chem. 2014, 33:243-267.
8. Chang S.-C., Das K., Ehresman D.J., Ellefson M.E., Gorman G.S., Hart J.A., Noker P.E., Tan Y.-M., Lieder P.H., Lau C., Olsen G.W., Butenhoff J.L. Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water. Toxicol. Sci. 2008, 104:40-53.
9. Chengelis C.P., Kirkpatrick J.B., Myers N.R., Shinohara M., Stetson P.L., Sved D.W. Comparison of the toxicokinetic behavior of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in cynomolgus monkeys and rats. Reprod. Toxicol. 2009, 27:400-406.
10. Del Vento S., Halsall C., Gioia R., Jones K., Dachs J. Volatile per- and polyfluoroalkyl compounds in the remote atmosphere of the western Antarctic Peninsula: an indirect source of perfluoroalkyl acids to Antarctic water?. Atmos. Pollut. Res. 2012, 3:450-455.
11. DeLorme M.P., Serex T.L., Frame S.R., Buck R.C., Loveless S.E. 6:2 Fluorotelomer alcohol: one-week inhalation toxicity study. The Toxicologist 2011, 120:134. (Abstract# 587).
12. Dreyer A., Weinberg I., Temme C., Ebinghaus R. Polyfluorinated compounds in the atmosphere of the atlantic and southern oceans: evidence for a global distribution. Environ. Sci. Technol. 2009, 43:6507-6514.
13. Ericson Jogsten I., Nadal M., van Bavel B., Lindström G., Domingo J.L. Per- and polyfluorinated compounds (PFCs) in house dust and indoor air in Catalonia, Spain: implications for human exposure. Environ. Int. 2012, 39:172-180.
14. Fraser A.J., Webster T.F., Watkins D.J., Nelson J.W., Stapleton H.M., Calafat A.M., Kato K., Shoeib M., Vieira V.M., McClean M.D. Polyfluorinated compounds in serum linked to indoor air in office environments. Environ. Sci. Technol. 2012, 46:1209-1215.
15. Gannon S., Nabb D.L., Snow T.A., Mawn M.P., Serex T., Buck R.C. In vitro metabolism of 6-2 fluorotelomer alcohol in rat, mouse and human hepatocytes. The Toxicologist 2010, 114:97. (Abstract# 450).
16. Gannon S.A., Johnson T., Nabb D.L., Serex T.L., Buck R.C., Loveless S.E. Absorption, distribution, metabolism, and excretion of [1-14C]-perfluorohexanoate ([14C]-PFHx) in rats and mice. Toxicology 2011, 283:55-62.
17. Gannon S.A., Mawn M.P., Munley S.W., Serex T.L., C.B.R. Toxicokinetic evaluation of 6:2 fluorotelomer alcohol and metabolites in rats following 90-days of oral exposure. The Toxicologist 2012, 126:402. (Abstract #206).
18. Haug L.S., Huber S., Schlabach M., Becher G., Thomsen C. Investigation on per- and polyfluorinated compounds in paired samples of house dust and indoor air from Norwegian homes. Environ. Sci. Technol. 2011, 45:7991-7998.
19. Himmelstein M., Shen Z.A., Ng S., DeLorme M., Buck R., Serex T. Plasma metabolites and dosimetry of 6:2 fluorotelomer alcohol in rats following 1-, 5- and 28-day inhalation exposures. The Toxicologist 2012, 126:402.
20. Himmelstein M., Serex T., Buck R., Russell M. Toxicokinetics of inhalation, metabolism and elimination of 6:2 FTOH and 8:2 FTOH in rats. The Toxicologist 2013, 132:105.
21. Jahnke A., Ahrens L., Ebinghaus R., Temme C. Urban versus remote Air concentrations of fluorotelomer alcohols and other polyfluorinated alkyl substances in Germany. Environ. Sci. Technol. 2007, 41:745-752.
22. Kelly D.P., Serex T.L., Buck R.C., Loveless S.E., DeLorme M.P. 6:2 Fluorotelomer alcohol: inhalation exposure, atmosphere characterization and acute inhalation toxicity. The Toxicologist 2011, 120:134. (Abstract #586).
23. Langer V., Dreyer A., Ebinghaus R. Polyfluorinated compounds in residential and nonresidential indoor air. Environ. Sci. Technol. 2010, 44:8075-8081.
24. Liu J., Mejia Avendano S. Microbial degradation of polyfluoroalkyl chemicals in the environment: a review. Environ. Int. 2013, 61C:98-114.
25. Liu W., Takahashi S., Sakuramachi Y., Harada K.H., Koizumi A. Polyfluorinated telomers in indoor air of Japanese houses. Chemosphere 2013, 90:1672-1677.
26. Nilsson H., Kärrman A., Rotander A., van Bavel B., Lindström G., Westberg H. Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans. Environ. Int. 2013, 51:8-12.
27. O'Connor J.C., Munley S.M., Serex T.L., Buck R.C. Evaluation of the reproductive and developmental toxicity of 6:2 fluorotelomer alcohol in rats. Toxicology 2014, 317:6-16.
28. Ohmori K., Kudo N., Katayama K., Kawashima Y. Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length. Toxicology 2003, 184:135-140.
29. Olsen G.W., Lange C.C., Ellefson M.E., Mair D.C., Church T.R., Goldberg C.L., Herron R.M., Medhdizadehkashi Z., Nobiletti J.B., Rios J.A., Reagen W.K., Zobel L.R. Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000-2010. Environ. Sci. Technol. 2012, 46:6330-6338.
30. Oono S., Harada K.H., Mahmoud M.A.M., Inoue K., Koizumi A. Current levels of airborne polyfluorinated telomers in Japan. Chemosphere 2008, 73:932-937.
31. Piekarz A.M., Primbs T., Field J.A., Barofsky D.F., Simonich S. Semivolatile fluorinated organic compounds in Asian and Western U.S. Air Masses. Environ. Sci. Technol. 2007, 41:8248-8255.
32. Russell M.H., Nilsson H., Buck R.C. Elimination kinetics of perfluorohexanoic acid in humans and comparison with mouse, rat and monkey. Chemosphere 2013, 93:2419-2425.
33. Serex T., Morris C., Buck R., Loveless S., DeLorme M. 6:2 Fluorotelomer alcohol: four-week inhalation toxicity study. The Toxicologist 2012, 126:56.
34. Serex T., Anand S., Munley S., Donner E.M., Frame S.R., Buck R.C., Loveless S.E. Toxicological evaluation of 6:2 fluorotelomer alcohol. Toxicology 2014, 319:1-9.
35. Shoeib M., Vlahos P., Harner T., Peters A., Graustein M., Narayan J. Survey of polyfluorinated chemicals (PFCs) in the atmosphere over the northeast Atlantic Ocean. Atmos. Environ. 2010, 44:2887-2893.
36. Shoeib M., Harner T., Webster G.M., Lee S.C. Indoor sources of poly- and perfluorinated compounds (PFCS) in Vancouver, Canada: implications for human exposure. Environ. Sci. Technol. 2011, 45:7999-8005.
37. Wagner J.G. Fundamentals of Clinical Pharmacokinetics 1975, Drug Intelligence Publications Inc, Hamilton, IL.