Elimination kinetics of perfluorohexanoic acid in humans and comparison with mouse, rat and monkey

Chemosphere

Volumn 93, Issue 10, 2013, Pages 2419-2425

  Russell, Mark H ^a   Nilsson, Helena ^b   Buck, Robert C ^a  

^a DUPONT COMPANY   (United States)

^b ÖREBRO UNIVERSITY   (Sweden)

Author keywords

Clearance; Half life; Human; Mammals; Perfluorohexanoic acid; PFHxA

Indexed keywords

MAMMALS; RISK ASSESSMENT;

CHEMICAL MANUFACTURERS; CLEARANCE; ENVIRONMENTAL , HEALTH AND SAFETIES; HALF LIVES; HUMAN; HUMAN RISK ASSESSMENT; PERFLUOROALKYL ACIDS; PFHXA;

RATS;

HEXANOIC ACID DERIVATIVE; PERFLUOROHEXANOIC ACID; UNCLASSIFIED DRUG; FLUOROCARBON; POLLUTANT;

BIOMONITORING; BIOTA; BLOOD; CHEMICAL COMPOUND; HEALTH AND SAFETY; HEALTH RISK; KINETICS;

ARTICLE; BIOLOGICAL MONITORING; BODY WEIGHT; CHEMICAL ANALYSIS; CLINICAL ARTICLE; ELIMINATION REACTION; HALF LIFE TIME; HAPLORHINI; HUMAN; KINETICS; MALE; MOUSE; NONHUMAN; RAT; ANIMAL; COMPARATIVE STUDY; DOSE RESPONSE; METABOLISM; POLLUTANT; SPECIES DIFFERENCE;

ANIMALIA; MAMMALIA; MUS; RATTUS;

ANIMALS; CAPROATES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FLUOROCARBONS; HALF-LIFE; HAPLORHINI; HUMANS; KINETICS; MICE; RATS; SPECIES SPECIFICITY;

EID: 84886948039     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2013.08.060     Document Type: Article

References (49)

1. Bartell S.M. Bias in half-life estimates using log concentration regression in the presence of background exposures, and potential solutions. J. Expos. Sci. Environ. Epidemiol. 2012, 22:299-303.
2. Bischel H.N., Macmanus-Spencer L.A., Zhang C., Luthy R.G. Strong associations of short-chain perfluoroalkyl acids with serum albumin and investigation of binding mechanisms. Environ. Toxicol. Chem. 2011, 30:2423-2430.
3. Buck R.C., Franklin J., Berger U., Conder J.M., Cousins I.T., de Voogt P., Jensen A.A., Kannan K., Mabury S.A., van Leeuwen S.P.J. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr. Environ. Assess. Manage. 2011, 7:513-541.
4. Chang S.C., Das K., Ehresman D.J., Ellefson M.E., Gorman G.S., Hart J.A., Noker P.E., Tan Y.M., Lieder P.H., Lau C., Olsen G.W., Butenhoff J.L. Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water. Toxicol. Sci.: Off. J. Soc. Toxicol. 2008, 104:40-53.
5. Chengelis C.P., Kirkpatrick J.B., Myers N.R., Shinohara M., Stetson P.L., Sved D.W. Comparison of the toxicokinetic behavior of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in cynomolgus monkeys and rats. Reprod. Toxicol. 2009, 27:400-406.
6. Chengelis C.P., Kirkpatrick J.B., Radovsky A., Shinohara M. A 90-day repeated dose oral (gavage) toxicity study of perfluorohexanoic acid (PFHxA) in rats (with functional observational battery and motor activity determinations). Reprod. Toxicol. 2009, 27:342-351.
7. Conder J.M., Hoke R.A., de Wolf W., Russell M.H., Buck R.C. Are PFCAs bioaccumulative? a critical review and comparison with regulatory criteria and persistent lipophilic compounds. Environ. Sci. Technol. 2008, 42:995-1003.
8. Cronkhite, L., 2012. 2010/15 PFOA Stewardship Program. In: 4th International Workshop Per- and Polyfluorinated Alkyl Substances (PFAS), Idstein, Germany.
9. Falandysz J., Taniyasu S., Gulkowska A., Yamashita N., Schulte-Oehlmann U. Is Fish a Major Source of Fluorinated Surfactants and Repellents in Humans Living on the Baltic Coast?. Environ Sci Technol 2006, 40:748-751.
10. Frisbee S.J., Brooks A.P., Maher A., Flensborg P., Arnold S., Fletcher T., Steenland K., Shankar A., Knox S.S., Pollard C., Halverson J.A., Vieira V.M., Jin C., Leyden K.M., Ducatman A.M. The C8 health project: design, methods, and participants. Environ. Health Perspect. 2009, 117.
11. Fromme H., Tittlemier S.A., Völkel W., Wilhelm M., Twardella D. Perfluorinated compounds - exposure assessment for the general population in western countries. Int. J. Hyg. Environ. Health 2009, 212:239-270.
12. Gannon, S., Johnson, T., Serex, T., Buck, R., 2009. Absorption, distribution, and excretion of [Carbonyl-14C]-Perfluorohexanoic acid in rats and mice. The Toxicologist, Supplement to Toxicological Sciences 108, 201 (Abstract # 972).
13. Gannon, S., Nabb, D.L., Snow, T.A., Mawn, M.P., Serex, T., Buck R.C., 2010. In vitro metabolism of 6-2 fluorotelomer alcohol in rat, mouse and human hepatocytes. The Toxicologist - An official Journal of the Society of Toxicology, 97 (Abstract# 450).
14. Gannon S.A., Johnson T., Nabb D.L., Serex T.L., Buck R.C., Loveless S.E. Absorption, distribution, metabolism, and excretion of [1-14C]-perfluorohexanoate ([14C]-PFHx) in rats and mice. Toxicology 2011, 283:55-62.
15. Guo F., Zhong Y., Wang Y., Li J., Zhang J., Liu J., Zhao Y. Perfluorinated compounds in human blood around Bohai Sea, China. Chemosphere 2011, 85:156-162.
16. Guruge K.S., Taniyasu S., Yamashita N., Wijeratna S., Mohotti K.M., Seneviratne H.R., Kannan K., Yamanaka N., Miyazaki S. Perfluorinated organic compounds in human blood serum and seminal plasma: a study of urban and rural tea worker populations in Sri Lanka. J Environ Monitor 2005, 7:371-377.
17. Han X., Nabb D.L., Russell M.H., Kennedy G.L., Rickard R.W. Renal elimination of perfluorocarboxylates (PFCAs). Chem. Res. Toxicol. 2012, 25:35-46.
18. Himmelstein, M., Slezak, B., Buck, R., Korzeniowski, S., Decker, E., 2008. Sodium perfluorohexanoate pharmacokinetics in rats during and after 90-day gavage administration. Supplement to Toxicological Sciences, 107, Abstract # 957, Denver, CO, USA.
19. Himmelstein, M.W., Shen, Z.A., Ng, S.P., DeLorme, M.P., Buck, R.C., Serex, T.L., 2012a. Plasma metabolites and dosimetry of 6:2 fluorotelomer alcohol in rats following 1-, 5- and 28-day inhalation exposures. In: 51st Annual Meeting of the Society of Toxicology, San Francisco, CA.
20. Himmelstein, M.W., Shen, Z.A., P., N.S., DeLorme, M.P., Buck, R.C., Serex, T.L., 2012b. Plasma metabolites and dosimetry of 6:2 fluorotelomer alcohol in rats following 1-, 5- and 28-day inhalation exposures. Toxicological Sciences 126, SOT Poster #1872.
21. IPCS, 2005. Chemical-specific adjustment factors for interspecies differences and human variability: guidance document for use of data in dose/concentration-response assessment. World Health Organization, Geneva, p. 96.
22. Iwai H. Toxicokinetics of ammonium perfluorohexanoate. Drug Chem. Toxicol. 2011, 34:341-346.
23. Kärrman A., van Bavel B., Jaernberg U., Hardell L., Lindstroem G. Perfluorinated chemicals in relation to other persistent organic pollutants in human blood. Chemosphere 2006, 64:1582-1591.
24. Kato K., Wong L.Y., Jia L.T., Kuklenyik Z., Calafat A.M. Trends in exposure to polyfluoroalkyl chemicals in the US Population: 1999-2008. Environ. Sci. Technol. 2011, 45:8037-8045.
25. Lee H., Mabury S.A. A Pilot Survey of Legacy and Current Commercial Fluorinated Chemicals in Human Sera from United States Donors in 2009. Environmental science & technology 2011, 45:8067-8074.
26. Li X., Zhang J., Liu W., Zhang X., Jiang Y., Zhou J., Jin Y. Serum levels of perfluorinated compounds in the general population in Shenzhen, China. Chinese Science Bulletin 2011, 56:3092-3099.
27. Liou J.S.C., Szostek B., DeRito C.M., Madsen E.L. Investigating the biodegradability of perfluorooctanoic acid. Chemosphere 2010, 80:176-183.
28. Liu J., Wang N., Szostek B., Buck R.C., Panciroli P.K., Folsom P.W., Sulecki L.M., Bellin C.A. 6-2 Fluorotelomer alcohol aerobic biodegradation in soil and mixed bacterial culture. Chemosphere 2010, 78:437-444.
29. Loveless S.E., Slezak B., Serex T., Lewis J., Mukerji P., O'Connor J.C., Donner E.M., Frame S.R., Korzeniowski S.H., Buck R.C. Toxicological evaluation of sodium perfluorohexanoate. Toxicology 2009, 264:32-44.
30. Mahmood I. Interspecies scaling: Predicting volumes, mean residence time and elimination half-life. Some suggestions. J. Pharm. Pharmacol. 1998, 50:493-499.
31. Martin J.W., Mabury S.A., Solomon K.R., Muir D.C. Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss). Environ. Toxicol. Chem. 2003, 22:196-204.
32. Martin J.W., Mabury S.A., Solomon K.R., Muir D.C. Dietary accumulation of perfluorinated acids in juvenile rainbow trout (Oncorhynchus mykiss). Environ. Toxicol. Chem. 2003, 22:189-195.
33. Miyake Y., Yamashita N., So M.K., Rostkowski P., Taniyasu S., Lam P.K.S., Kannan K. Trace analysis of total fluorine in human blood using combustion ion chromatography for fluorine: A mass balance approach for the determination of known and unknown organofluorine compounds. Journal of Chromatography, A 2007, 1154:214-221.
34. Nilsson H., Karrman A., Westberg H., Rotander A., Lindstrom G. A time trend study of significantly elevated perfluorocarboxylate levels in humans after using fluorinated ski wax. Environ. Sci. Technol. 2010, 44:2150-2156.
35. Nilsson H., Rotander A., Van Bavel B., Lindström G., Westberg H. Inhalation exposure to fluorotelomer alcohols yield perfluorocarboxylates in human blood?. Environ. Sci. Technol. 2010, 44:7717-7722.
36. Nilsson H., Kärrman A., Rotander A., van Bavel B., Lindström G., Westberg H. Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans. Environ. Int. 2013, 51:8-12.
37. Noker, P.E., 2001. A pharmacokinetic study of potassium perfluorohexanoate in the Cynomolgus monkey. Southern Research Institute.
38. OECD, 2010. Portal on Perfluorinated Chemicals.
39. Olsen G.W., Burris J.M., Ehresman D.J., Froehlich J.W., Seacat A.M., Butenhoff J.L., Zobel L.R. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ. Health Perspect. 2007, 115:1298-1305.
40. Olsen G.W., Chang S.-C., Noker P.E., Gorman G.S., Ehresman D.J., Lieder P.H., Butenhoff J.L. A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans. Toxicology 2009, 256:65-74.
41. Olsen G.W., Lange C.C., Ellefson M.E., Mair D.C., Church T.R., Goldberg C.L., Herron R.M., Medhdizadehkashi Z., Nobiletti J.B., Rios J.A., Reagen W.K., Zobel L.R. Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000-2010. Environ. Sci. Technol. 2012, 46:6330-6338.
42. a of perfluoroalkyl carboxylic acids. J. Mol. Struct. (Thoechem) 2010, 949:60-69.
43. Ritter S.K. Fluorochemicals go short. Chem. Eng. News 2010, 88:12-17.
44. USEPA, 2010. 2010/2015 PFOA Stewardship Program. http://www.epa.gov/oppt/pfoa/pubs/stewardship/index.html.
45. Vestergren, R., Cousins Ian, T., Trudel, D., Wormuth, M., Scheringer, M., 2008. Considering the role of precursor compounds for consumer exposure to PFOS and PFOA. In: 1st International Workshop. Fluorinated surfactants: New Developments, Idstein, Germany.
46. Weaver Y.M., Ehresman D.J., Butenhoff J.L., Hagenbuch B. Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths. Toxicol. Sci. 2010, 113:305-314.
47. WWF, 2004. Chemical Check Up: An analysis of chemicals in the blood of Members of the European Parliament. p. 91.
48. Yang C.H., Glover K.P., Han X. Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates. Toxicol. Sci. 2010, 117:294-302.
49. Yeung L.W.Y., Miyake Y., Taniyasu S., Wang Y., Yu H., So M.K., Jiang G., Wu Y., Li J., Giesy J.P., Yamashita N., Lam P.K.S. Perfluorinated Compounds and Total and Extractable Organic Fluorine in Human Blood Samples from China. Environ. Sci. Technol. 2008, 42:8140-8145.