Structural identification of the Vps18 β-propeller reveals a critical role in the HOPS complex stability and function

Journal of Biological Chemistry

Volumn 289, Issue 48, 2014, Pages 33503-33512

  Behrmann, Heide ^a,b   Lürick, Anna ^c   Kuhlee, Anne ^d   Balderhaar, Henning Kleine ^c   Bröcker, Cornelia ^c   Kümmel, Daniel ^c   Engelbrecht Vandré, Siegfried ^c   Gohlke, Ulrich ^a   Raunser, Stefan ^d   Heinemann, Udo ^a,b   Ungermann, Christian ^c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF OSNABRÜCK   (Germany)

^d MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; PROTEINS; STRUCTURAL ANALYSIS;

COMPLEX STABILITY; IN-VITRO; MEMBRANE FUSION; N-TERMINAL DOMAINS; N-TERMINALS; STRUCTURAL IDENTIFICATION;

PROPELLERS;

HOPS PROTEIN COMPLEX; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE VPS18 BETA; UNCLASSIFIED DRUG; MULTIPROTEIN COMPLEX; PEP3 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE DELETION; IN VITRO STUDY; MEMBRANE FUSION; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; CHEMISTRY; COATED VESICLE; GENETICS; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; COP-COATED VESICLES; MULTIPROTEIN COMPLEXES; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84912084732     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.602714     Document Type: Article

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