Pharmacological and safety evaluation of fibrous root of Rhizoma Coptidis

Environmental Toxicology and Pharmacology

Volumn 39, Issue 1, 2015, Pages 53-69

  Ning, Na ^a,b   Wang, Yan Zhi ^a   Zou, Zong Yao ^a   Zhang, De Zhou ^a   Wang, De Zhen ^a   Li, Xue Gang ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b Tongren Polytechnic College   (China)

Author keywords

Acute toxicity; Fibrous root; Mutagenicity; Pharmacological activities; Rhizoma Coptidis; Sub chronic toxicity

Indexed keywords

ACETYLSALICYLIC ACID; BERBERINE; HERBACEOUS AGENT; ANTIINFECTIVE AGENT; ANTIPYRETIC AGENT; LIPOPOLYSACCHARIDE; PLANT EXTRACT;

ACUTE TOXICITY; ADULT; AMES TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CHRONIC TOXICITY; CONTROLLED STUDY; COPTIS; DOSE RESPONSE; DRUG SAFETY; ESCHERICHIA COLI INFECTION; FIBROUS ROOT; HYPERPYREXIA; LIVER INJURY; LUNG INJURY; MALE; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; PLANT ROOT; RAT; SEMEN ABNORMALITY; ANIMAL; DRUG EFFECTS; ESCHERICHIA COLI INFECTIONS; FEMALE; FEVER; INSTITUTE FOR CANCER RESEARCH MOUSE; LD50; MUTAGEN TESTING; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PHYTOTHERAPY; RABBIT; SPERMATOZOON; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIPYRETICS; COPTIS; ESCHERICHIA COLI INFECTIONS; FEMALE; FEVER; LETHAL DOSE 50; LIPOPOLYSACCHARIDES; MALE; MICE, INBRED ICR; MUTAGENICITY TESTS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RABBITS; RATS, SPRAGUE-DAWLEY; SPERMATOZOA; TOXICITY TESTS, SUBCHRONIC;

EID: 84912080856     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.11.006     Document Type: Article

References (56)

1. Al-Adhroey A.H., Nor Z.M., Al-Mekhlafi H.M., Amran A.A., Mahmud R. Antimalarial activity of methanolic leaf extract of Piper betle L. Molecules 2010, 16:107-118.
2. Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 1975, 31:347-364.
3. Ashby J. Is there a continuing role for the intraperitoneal injection route of exposure in short-term rodent genotoxicity assays?. Mutat. Res. 1985, 156:239-243.
4. CFDA, 2005a. No. [Z]GPT1-1: technical guidelines of general pharmacology test for traditional Chinese medicine and natural drugs. CFDA Guidelines for the Evaluation of Drug, pp. 1-8.
5. CFDA, 2005b. No. [Z]GPT2-1: technical guidelines of acute toxicity for traditional Chinese medicine and natural drugs. CFDA Guidelines for the Evaluation of Drug, pp. 1-8.
6. CFDA, 2005c. No. [Z]GPT3-1: technical guidelines of long term toxicity for traditional Chinese medicine and natural drugs. CFDA Guidelines for the Evaluation of Drug, pp. 1-8.
7. Chawla R. Methods and Interpretations 1999, Jaypee Brothers Medical Publishers, New Delhi. 2nd ed.
8. Chen H.Y., Ye X.L., Cui X.L., He K., Jin Y.N., Chen Z., Li X.G. Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells. Fitoterapia 2012, 83:67-73.
9. Chinese Pharmcopoeia Committee Pharmacopeia of the People's Republic of China 2010, Chinese Medical Science Press, Beijing. 9th ed.
10. Chu M., Ding R., Chu Z.Y., Zhang M.B., Liu X.Y., Xie S.H., Zhai Y.J., Wang Y.D. Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor. BMC Complement. Altern. Med. 2014, 14:89.
11. Commission of Chinese Veterinary Pharmacopoeia Chinese Veterinary Pharmacopoeia 2010, China Agriculture Press, Beijing. 4th ed.
12. Davis M.E., Berndt W.D. Principles and Methods in toxicology 1994, Raven Press, New York. 3rd ed.
13. Deng L.H., Lei J.D., H J., J L., Wang L.Y., Zhang R., Liu X.H., Liu Y. Evaluation on genotoxicity and teratogenicity of aqueous extract from Cyclocarya paliurus leaves. Scientific World J. 2014, 2014:1-12.
14. Diao E., Hou H., Chen B., Shan C., Dong H. Ozonolysis efficiency and safety evaluation of aflatoxin B1 in peanuts. Food Chem. Toxicol. 2013, 55:519-525.
15. El Hilaly J., Israili Z.H., Lyoussi B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. J. Ethnopharmacol. 2004, 91:43-50.
16. Ezeonwumelu J.O.C., Julius A.K., Muhoho C.N., Ajayi A.M., Oyewale A.A., Tanayen J.K., Balogun S.O., Ibrahim A., Adzu B., Adiukwu C.P., Oloro J., Kiplagat D.M., Goji A.D.T., Okoruwa A.G., Onchweri A.N., Reddy P.M.K. Biochemical and histological studies of aqueous extract of Bidens pilosa leaves from Ugandan Rift Valley in rats. Br. J. Clin. Pharmacol. 2011, 2:302-309.
17. European Pharmacopoeia Commission European Pharmacopeia 2013, European Directorate for the Quality Control of Medicines, Strasbourg. 8th ed.
18. Ezejiofor A.N., Orish C.N., Orisakwe O.E. Effect of aqueous leaves extract of Costus afer Ker Gawl (Zingiberaceae) on the liver and kidney of male albino Wistar rat. Anc. Sci. Life 2013, 33:4-9.
19. Guyton A.C., Hall J.E. Textbook of Medical Physiology 2000, W.B. Saunders Company, Philadelphia. 10th ed.
20. Heddle J.A., Stuart E., Salamone M.F. The bone marrow micronucleus test. Handbook of Mutagenicity Test Procedures 1984, 441-457. Elsevier, Amsterdam. 2nd ed. B.J. Kilber, M. Legator, W. Nichols, C. Ramel (Eds.).
21. Japanese Pharmcopoeia Editorial Committee, 2011. Japanese Pharmacopeia, sixteenth ed. Ministry of Health Labour and Welfare, Shibuya.
22. Jothy S.L., Zakaria Z., Chen Y., Lau Y.L., Latha L.Y., Sasidharan S. Acute oral toxicity of methanolic seed extract of Cassia fistula in mice. Molecules 2011, 16:5268-5282.
23. 50. J. Appl. Toxicol. 1986, 6:145-148.
24. Lan J., Yang S.L., Zheng Y.Q., Sao J.B., Li Y. Advances in studies on Coptis chinensis. Chin. Tradit. Herbal Drugs 2001, 32:1139-1141.
25. Lin M.T., Chern Y.F., Chen S.Y. Depletion of noradrenaline in the hypothalamus reduces the febrile responses induced by prostaglandin E2, thyrotropin-releasing hormone and beta-endorphin in rats. Neuropharmacology 1985, 24:1039-1042.
26. Liu M., Ye X.L., Liang Y.T., Wang L., Lan P., Chen X., Huang W.W., Li X.G. Technology for joint producing total and monomeric alkaloids from fibrous root of Coptis chinensis Franch. Lishizhen Med. Mater. Med. Res. 2010, 21:1644-1646.
27. Lyoussi B., E H.I., Israili Z.H. Acute and chronic toxicological studies of Ajuva iva in experimental animals. J. Ethnopharmacol. 2004, 91:43-50.
28. Ma B.L., Ma Y.M., Shi R., Wang T.M., Zhang N., Wang C.H., Yang Y. Identification of the toxic constituents in Rhizoma Coptidis. J. Ethnopharmacol. 2010, 128:357-364.
29. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983, 113:173-215.
30. McNaught A.D., Wilkinson A. Compendium of Chemical Terminology ("The Gold Book") 1997, Blackwell Science, Oxford. 2nd ed.
31. MOH, 2004a. GB 15193.4-2003: Samlmonella Typhmurium/Mammals Microsomal Enzyme Test (Aest Test), pp. 33-43.
32. MOH, 2004b. GB15193.5-2003: Bone Marrow Cell Micronucleus Test, pp. 45-48.
33. MOH, 2004c. GB15193.7-2003:: Mice Sperm Abnormality Test, pp. 55-58.
34. Morimoto A., Murakami N., Nakamori T., Watanabe T. Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood-brain barrier in rabbits. J. Physiol. 1987, 383:629-637.
35. Mortelmans K., Zeiger E. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res. 2000, 455:29-60.
36. National Research Council Toxicity Testing For Assessing Enviromental Agents: Interim Report 2006, Naitonal Academies Press, Washington.
37. OECD Test No. 408: repeated dose 90-day oral toxicity study in rodents. OECD Guidelines for the Testing of Chemicals 2010, vol. 1:1-10.
38. OECD Test No. 425: acute oral toxicity: up-and-down procedure. OECD Guidelines for the Testing of Chemicals 2010, vol. 1:1-27.
39. OECD Test No. 471: bacterial reverse mutation test. OECD Guidelines for the Testing of Chemicals 2010, vol. 1:1-11.
40. OECD Test No. 474: mammalian erythrocyte micronucleus test. OECD Guidelines for the Testing of Chemicals 2010, vol. 1:1-10.
41. Qiu S.H., Tang H.B., Li F.Y., Xiao J.R., Chen B.Y. Experimental study of the acute toxicity on cmmon-used bitter and cold medicnes. Cent. South Pharm. 2004, 2:37-38.
42. Redl H., Bahrami S., Schlag G., Traber D.L. Clinical detection of LPS and animal models of endotoxemia. Immunobiology 1993, 187:330-345.
43. Roopashree T.S., Raman D., Shobha Rani R.H., Narendra C. Acute oral toxicity studies of antipsoriatic herbal mixture comprising of aqueous extracts of Calendula officinalis, Momordica charantia, Cassia tora and Azadirachta indica seed oil. Thai J. Pharm. Sci. 2009, 33:74-83.
44. Saidu Y., Bilbis L.S., Lawal M., Isezuo S.A., Hassan S.W., Abbas A.Y. Acute and sub-chronic toxicity studies of crude aqueous extract of Albizzia chevalieri Harms (Leguminosae). Asian J. Biochem. 2007, 2:224-236.
45. Schmid W. The micronucleus test. Mutat. Res. 1975, 31:9-15.
46. Sun S.L., He F.L., Feng C.R. The application of Chinese herbal formula "Xi Chuan Ping" in heat stress in cow. China Anim. Health 2010, 7:9-12.
47. Tsai C.C., Lin M.T., Wang J.J., Liao J.F., Huang W.T. The antipyretic effects of baicalin in lipopolysaccharide-evoked fever in rabbits. Neuropharmacology 2006, 51:709-717.
48. Tubesha Z., Imam M.U., Mahmud R., Ismail M. Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats. Molecules 2013, 18:7460-7472.
49. United States Pharmacopeia Convention, 2013. United States Pharmacopeia 37 - National Formulary 32, thirty-seventh ed. The United States Pharmacopeia Convention, Rockville.
50. van der Zande M., Vandebriel R.J., Groot M.J., Kramer E., Herrera Rivera Z.E., Rasmussen K., Ossenkoppele J.S., Tromp P., Gremmer E.R., Peters R.J., Hendriksen P.J., Marvin H.J., Hoogenboom R.L., Peijnenburg A.A., Bouwmeester H. Sub-chronic toxicity study in rats orally exposed to nanostructured silica. Part. Fibre Toxicol. 2014, 11:1743-8977.
51. Van Miert A.S., Van Duin C.T. The antipyretic effect of flurbiprofen. Eur. J. Pharmacol. 1977, 44:197-204.
52. Wang C.G., T Z., Zhang J.L. Chinese pulsatilla extracts eliminate resisitance of Escherichial coli to streptomycin. Afr. J. Microbiol. Res. 2011, 5:3583-3587.
53. Wang L., Zhao Z.Q., Li X.G. The applicatioin of fibrous root of Rhizoma Coptidis in aminials with diarrhea. China Anim. Health 2010, 12:45-46.
54. Wyrobek A.J., Bruce W.R. Chemical induction of sperm abnormalities in mice. Proc. Natl. Acad. Sci. U.S.A. 1975, 72:4425-4429.
55. Yakubu M.T., Akanji M.A., Oladiji A.T. Hematological evaluation in male albino rats following chronic administration of aqueous extract of Fadogia agrestis stem. Pharmacogn. Mag. 2007, 3:34.
56. Yi J., Ye X., Wang D., He K., Yang Y., Liu X., Li X. Safety evaluation of main alkaloids from Rhizoma Coptidis. J. Ethnopharmacol. 2013, 145:303-310.