Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Chow, I Ting ^a   Yang, Junbao ^a   Gates, Theresa J ^a   James, Eddie A ^a   Mai, Duy T ^a   Greenbaum, Carla ^a   Kwok, William W ^a,b  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 65 121-140; GLUTAMATE DECARBOXYLASE 65 250-266; HLA DQ8 ANTIGEN; INTERLEUKIN 17; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG; GLUTAMATE DECARBOXYLASE; HLA DQ ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL SPECIFICITY; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETOGENESIS; DISEASE COURSE; DISEASE PREDISPOSITION; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE CLONE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; SCHOOL CHILD; STAINING; TH1 CELL; GENETICS; IMMUNOLOGY; METABOLISM; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; WASHINGTON;

CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; GLUTAMATE DECARBOXYLASE; HLA-DQ ANTIGENS; HUMANS; STATISTICS, NONPARAMETRIC; WASHINGTON;

EID: 84912079287     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112882     Document Type: Article

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