메뉴 건너뛰기




Volumn 19, Issue 11, 2014, Pages 19066-19077

Pentadecapeptide bpc 157 enhances the growth hormone receptor expression in tendon fibroblasts

Author keywords

BPC 157; Growth hormone receptor; PCNA; Proliferation; Tendon fibroblast

Indexed keywords

CYCLINE; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; JANUS KINASE 2; PEPTIDE FRAGMENT; PROTEIN;

EID: 84912073103     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules191119066     Document Type: Article
Times cited : (72)

References (33)
  • 1
    • 0026686402 scopus 로고
    • Functional anatomy and physiology of tendons
    • O'Brien, M. Functional anatomy and physiology of tendons. Clin. Sports Med. 1992, 11, 505-520
    • (1992) Clin. Sports Med. , vol.11 , pp. 505-520
    • O'Brien, M.1
  • 5
    • 0033060271 scopus 로고    scopus 로고
    • Enhanced tendon healing with GDF 5 and 6
    • Aspenberg, P.; Forslund, C. Enhanced tendon healing with GDF 5 and 6. Acta Orthop. Scand. 1999, 70, 51-54
    • (1999) Acta Orthop. Scand. , vol.70 , pp. 51-54
    • Aspenberg, P.1    Forslund, C.2
  • 6
    • 0029907306 scopus 로고    scopus 로고
    • Growth hormone and the insulin-like growth factor system in myogenesis
    • Florini, J.R.; Ewton, D.Z.; Coolican, S.A. Growth hormone and the insulin-like growth factor system in myogenesis. Endocr. Rev. 1996, 17, 481-517
    • (1996) Endocr. Rev. , vol.17 , pp. 481-517
    • Florini, J.R.1    Ewton, D.Z.2    Coolican, S.A.3
  • 8
    • 0024364243 scopus 로고
    • Growth hormone influences collagen deposition and mechanical strength of intact rat skin. A dose-response study
    • Jorgensen, P.H.; Andreassen, T.T.; Jorgensen, K.D. Growth hormone influences collagen deposition and mechanical strength of intact rat skin. A dose-response study. Acta Endocrinol. 1989, 120, 767-772
    • (1989) Acta Endocrinol. , vol.120 , pp. 767-772
    • Jorgensen, P.H.1    Andreassen, T.T.2    Jorgensen, K.D.3
  • 9
    • 0024561403 scopus 로고
    • Stimulation of collagen formation by insulin and insulin-like growth factor i in cultures of human lung fibroblasts
    • Goldstein, R.H.; Poliks, C.F.; Pilch, P.F.; Smith, B.D.; Fine, A. Stimulation of collagen formation by insulin and insulin-like growth factor I in cultures of human lung fibroblasts. Endocrinology 1989, 124, 964-970
    • (1989) Endocrinology , vol.124 , pp. 964-970
    • Goldstein, R.H.1    Poliks, C.F.2    Pilch, P.F.3    Smith, B.D.4    Fine, A.5
  • 10
    • 0025770170 scopus 로고
    • Growth hormone and insulin-like growth factor i regulate collagen gene expression and extracellular collagen in cultures of avian skin fibroblasts
    • Granot, I.; Halevy, O.; Hurwitz, S.; Pines, M. Growth hormone and insulin-like growth factor I regulate collagen gene expression and extracellular collagen in cultures of avian skin fibroblasts. Mol. Cell. Endocrinol. 1991, 80, 1-9
    • (1991) Mol. Cell. Endocrinol. , vol.80 , pp. 1-9
    • Granot, I.1    Halevy, O.2    Hurwitz, S.3    Pines, M.4
  • 12
    • 77955921088 scopus 로고    scopus 로고
    • The growth hormone receptor: Mechanism of activation and clinical implications
    • Brooks, A.J.; Waters, M.J. The growth hormone receptor: Mechanism of activation and clinical implications. Nat. Rev. Endocrinol. 2010, 6, 515-525
    • (2010) Nat. Rev. Endocrinol. , vol.6 , pp. 515-525
    • Brooks, A.J.1    Waters, M.J.2
  • 13
    • 0030633143 scopus 로고    scopus 로고
    • Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protective compound, BPC) and their specificity to gastric mucosal cells
    • Bodis, B.; Karadi, O.; Nemeth, P.; Dohoczky, C.; Kolega, M.; Mozsik, G. Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protective compound, BPC) and their specificity to gastric mucosal cells. Life Sci. 1997, 61, 243-248
    • (1997) Life Sci. , vol.61 , pp. 243-248
    • Bodis, B.1    Karadi, O.2    Nemeth, P.3    Dohoczky, C.4    Kolega, M.5    Mozsik, G.6
  • 14
    • 0002990658 scopus 로고    scopus 로고
    • Pentadecapeptide BPC-157 beneficially influences the healing of colon-colon anastamoses in rats
    • Mozsik, G., Nagy L., Par, A., Rainsford, K., Eds.; Kluwer Academic Publishers: Dodrecht, The Netherlands
    • Zoricic, I.; Sikiric, P.; Seiwerth, S. Pentadecapeptide BPC-157 beneficially influences the healing of colon-colon anastamoses in rats. In Cell Injury and Protection in the Gastrointestinal Tract. From Basic Science to Clinical Perspectives; Mozsik, G., Nagy, L., Par, A., Rainsford, K., Eds.; Kluwer Academic Publishers: Dodrecht, The Netherlands, 1997; pp. 249-258
    • (1997) Cell Injury and Protection in the Gastrointestinal Tract. from Basic Science to Clinical Perspectives , pp. 249-258
    • Zoricic, I.1    Sikiric, P.2    Seiwerth, S.3
  • 15
    • 0002145137 scopus 로고    scopus 로고
    • Effects of BPC-157 on the healing of corneal lesions
    • Ohno, S., Aoki, K., UsuiM., Eds.; Elsevier: Amsterdam, The Netherlands
    • Konjevoda, P.; Nasic, M.; Curkovic, T. Effects of BPC-157 on the healing of corneal lesions. In Uveitis Today; Ohno, S., Aoki, K., Usui, M., Eds.; Elsevier: Amsterdam, The Netherlands, 1998; pp. 311-314
    • (1998) Uveitis Today , pp. 311-314
    • Konjevoda, P.1    Nasic, M.2    Curkovic, T.3
  • 16
    • 0033105022 scopus 로고    scopus 로고
    • Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: A comparison with bone marrow and autologous cortical bone implantation
    • Sebecić, B.; Nikolić, V.; Sikirić, P.; Seiwerth, S.; Sosa, T.; Patrlj, L.; Grabarević, Z.; Rucman, R.; Petek, M.; Konjevoda, P.; et al. Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: A comparison with bone marrow and autologous cortical bone implantation. Bone 1999, 24, 195-202
    • (1999) Bone , vol.24 , pp. 195-202
    • Sebecić, B.1    Nikolić, V.2    Sikirić, P.3    Seiwerth, S.4    Sosa, T.5    Patrlj, L.6    Grabarević, Z.7    Rucman, R.8    Petek, M.9    Konjevoda, P.10
  • 17
    • 0034749860 scopus 로고    scopus 로고
    • Chronic cytoprotection: Pentadecapeptide BPC 157, ranitidine and propranolol prevent, attenuate and reverse the gastric lesions appearance in chronic alcohol drinking rats
    • Prkacin, I.; Aralica, G.; Perovic, D.; Separovic, J.; Gjurasin, M.; Lovric-Bencic, M.; Stancic-Rokotov, D.; Ziger, T.; Anic, T.; Sikiric, P.; et al. Chronic cytoprotection: Pentadecapeptide BPC 157, ranitidine and propranolol prevent, attenuate and reverse the gastric lesions appearance in chronic alcohol drinking rats. J. Physiol. Paris 2001, 95, 295-301
    • (2001) J. Physiol. Paris , vol.95 , pp. 295-301
    • Prkacin, I.1    Aralica, G.2    Perovic, D.3    Separovic, J.4    Gjurasin, M.5    Lovric-Bencic, M.6    Stancic-Rokotov, D.7    Ziger, T.8    Anic, T.9    Sikiric, P.10
  • 21
    • 14944387059 scopus 로고    scopus 로고
    • The stable gastric pentadcapeptide BPC 157, given locally, improve CO2 laser healing in mice
    • Bilic, M.; Bumber, Z.; Blagaic, A.B.; Batelja, L.; Seiwerth, S.; Sikiric, P. The stable gastric pentadcapeptide BPC 157, given locally, improve CO2 laser healing in mice. Burns 2005, 31, 310-315
    • (2005) Burns , vol.31 , pp. 310-315
    • Bilic, M.1    Bumber, Z.2    Blagaic, A.B.3    Batelja, L.4    Seiwerth, S.5    Sikiric, P.6
  • 23
    • 33744499697 scopus 로고    scopus 로고
    • Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation
    • Krivic, A.; Anic, T.; Seiwerth, S.; Huljev, D.; Sikiric, P. Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation. J. Orthop. Res. 2006, 24, 982-989
    • (2006) J. Orthop. Res. , vol.24 , pp. 982-989
    • Krivic, A.1    Anic, T.2    Seiwerth, S.3    Huljev, D.4    Sikiric, P.5
  • 24
    • 52949096054 scopus 로고    scopus 로고
    • Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: Role of the nitric oxide-system
    • Klicek, R.; Sever, M.; Radic, B.; Drmic, D.; Kocman, I.; Zoricic, I.; Vuksic, T.; Ivica, M.; Barisic, I.; Ilic, S.; et al. Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: Role of the nitric oxide-system. J. Pharmacol. Sci. 2008, 108, 7-17
    • (2008) J. Pharmacol. Sci. , vol.108 , pp. 7-17
    • Klicek, R.1    Sever, M.2    Radic, B.3    Drmic, D.4    Kocman, I.5    Zoricic, I.6    Vuksic, T.7    Ivica, M.8    Barisic, I.9    Ilic, S.10
  • 25
    • 33845912425 scopus 로고    scopus 로고
    • Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia Full and distended stomach, and vascular response
    • Sikiric, P.; Seiwerth, S.; Brcic, L.; Blagaic, A.B.; Zoricic, I.; Sever, M.; Klicek, R.; Radic, B.; Keller, N.; Sipos, K.; et al. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response. Inflammopharmacology 2006, 14, 214-221
    • (2006) Inflammopharmacology , vol.14 , pp. 214-221
    • Sikiric, P.1    Seiwerth, S.2    Brcic, L.3    Blagaic, A.B.4    Zoricic, I.5    Sever, M.6    Klicek, R.7    Radic, B.8    Keller, N.9    Sipos, K.10
  • 27
    • 33646175337 scopus 로고    scopus 로고
    • Microarray analysis of healing rat Achilles tendon: Evidence for glutamate signaling mechanisms and embryonic gene expression in healing tendon tissue
    • Molloy, T.J.; Wang, Y.; Horner, A.; Skerry, T.M.; Murrell, G.A. Microarray analysis of healing rat Achilles tendon: Evidence for glutamate signaling mechanisms and embryonic gene expression in healing tendon tissue. J. Orthop. Res. 2006, 24, 842-855
    • (2006) J. Orthop. Res. , vol.24 , pp. 842-855
    • Molloy, T.J.1    Wang, Y.2    Horner, A.3    Skerry, T.M.4    Murrell, G.A.5
  • 28
    • 0036216215 scopus 로고    scopus 로고
    • Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system
    • Khan, A.S.; Sane, D.C.; Wannenburg, T.; Sonntag, W.E. Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovasc. Res. 2002, 54, 25-35
    • (2002) Cardiovasc. Res. , vol.54 , pp. 25-35
    • Khan, A.S.1    Sane, D.C.2    Wannenburg, T.3    Sonntag, W.E.4
  • 29
    • 79954610862 scopus 로고    scopus 로고
    • The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
    • Chang, C.H.; Tsai, W.C.; Lin, M.S.; Hsu, Y.H.; Pang, J.H. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J. Appl. Physiol. 2011, 110, 774-780
    • (2011) J. Appl. Physiol. , vol.110 , pp. 774-780
    • Chang, C.H.1    Tsai, W.C.2    Lin, M.S.3    Hsu, Y.H.4    Pang, J.H.5
  • 30
    • 66749171691 scopus 로고    scopus 로고
    • The growth hormone cascade and its role in mammalian growth
    • Rosenfeld, R.G.; Hwa, V. The growth hormone cascade and its role in mammalian growth. Horm. Res. 2009, 71 (Suppl. 2), 36-40
    • (2009) Horm. Res. , vol.71 , pp. 36-40
    • Rosenfeld, R.G.1    Hwa, V.2
  • 31
    • 0028201017 scopus 로고
    • Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment
    • Taub, D.D.; Tsarfaty, G.; Lloyd, A.R.; Durum, S.K.; Longo, D.L.; Murphy, W.J. Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment. J. Clin. Invest. 1994, 94, 293-300
    • (1994) J. Clin. Invest. , vol.94 , pp. 293-300
    • Taub, D.D.1    Tsarfaty, G.2    Lloyd, A.R.3    Durum, S.K.4    Longo, D.L.5    Murphy, W.J.6
  • 32
    • 34548042976 scopus 로고    scopus 로고
    • Neuroendocrine control of T cell developmentin mammals: Role of growth hormone in modulating thymocyte migration
    • Savino, W. Neuroendocrine control of T cell developmentin mammals: Role of growth hormone in modulating thymocyte migration. Exp. Physiol. 2007, 92, 813-817
    • (2007) Exp. Physiol. , vol.92 , pp. 813-817
    • Savino, W.1
  • 33
    • 77649232071 scopus 로고    scopus 로고
    • The effect of growth hormone on fibroblast proliferation and keratinocyte migration
    • Lee, S.W.; Kim, J.Y.; Lee, Y. The effect of growth hormone on fibroblast proliferation and keratinocyte migration. J. Plast. Reconstr. Aesthet. Surg. 2010, 63, 364-369
    • (2010) J. Plast. Reconstr. Aesthet. Surg. , vol.63 , pp. 364-369
    • Lee, S.W.1    Kim, J.Y.2    Lee, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.