Health hazard assessment of occupationally di-(2-ethylhexyl)-phthalate-exposed workers in China

Chemosphere

Volumn 120, Issue , 2015, Pages 37-44

  Wang, Wenxin ^a   Xu, Xiaobing ^b   Fan, Chinbay Q ^c  

^a FUDAN UNIVERSITY   (China)

^b NANJING GENERAL HOSPITAL OF NANJING MILITARY COMMAND   (China)

^c GAS TECHNOLOGY INSTITUTE   (United States)

Author keywords

Biochemical monitoring; Di (2 ethylhexyl) phthalate; Health hazards; Occupational exposure; Plasma residues

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; BIOHAZARDS; CHLORINE COMPOUNDS; ENVIRONMENTAL PROTECTION AGENCY; ESTERS; HEALTH; PLANTS (BOTANY); POLYVINYL CHLORIDES; REGRESSION ANALYSIS; UREA;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DI(2-ETHYLHEXYL)PHTHALATE; GAMMA-GLUTAMYLTRANSFERASE; OCCUPATIONAL EXPOSURE; PLASMA RESIDUES; RESPIRABLE PARTICULATE MATTERS; US ENVIRONMENTAL PROTECTION AGENCY;

HEALTH HAZARDS;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CHOLINESTERASE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; MALONALDEHYDE; PHTHALIC ACID DERIVATIVE; POLYVINYLCHLORIDE; UREA; BIOLOGICAL MARKER; PARTICULATE MATTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

BIOMARKER; CHEMICAL INDUSTRY; CONCENTRATION (COMPOSITION); HEALTH RISK; OCCUPATIONAL EXPOSURE; POLLUTION EXPOSURE; RISK ASSESSMENT;

ADULT; AIR MONITOR; AIR POLLUTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATMOSPHERE; CHINA; CHOLINESTERASE BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROSS LINKING; DIZZINESS; DYSPNEA; FATIGUE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEADACHE; HUMAN; INDUSTRIAL WORKER; LIVER FUNCTION TEST; LIVER INJURY; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; MUSCLE WEAKNESS; NAUSEA; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; OCCUPATIONAL HEALTH; OXIDATION; OXIDATIVE STRESS; PARTICULATE MATTER; PROTEIN BLOOD LEVEL; RASH; RISK ASSESSMENT; SAFETY; UREA BLOOD LEVEL; VOMITING; ANALYSIS; BLOOD; CHEMICAL INDUSTRY; KIDNEY; LIVER; METABOLISM;

CHINA;

ADULT; ATMOSPHERE; BIOMARKERS; CHEMICAL INDUSTRY; CHINA; CHOLINESTERASES; DIETHYLHEXYL PHTHALATE; HUMANS; KIDNEY; LIVER; MALE; OCCUPATIONAL EXPOSURE; PARTICULATE MATTER; POLYVINYL CHLORIDE;

EID: 84912060726     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2014.05.053     Document Type: Article

References (38)

1. Andrade A.J.M., Grande S.W., Talsness C.E., Grote K., Chahoud I. A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring rats. Toxicology 2006, 228:85-97.
2. Benson R. Hazard to the developing male reproductive system from cumulative exposure to phthalate esters-dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate. Regul. Toxicol. Pharm. 2009, 53:90-101.
3. Bergmeyer H.U., Hereder M., Rej R. Approved recommendation 1985 on IFCC method for the measurement of catalytic concentration of enzymes Part 2. IFCC method for aspartate aminotransferase. J. Clin. Chem. Clin. Biochem. 1998, 24:49.
4. Calafat A.M., McKee R.H. Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study. Environ. Health Perspect. 2006, 114:1783-1789.
5. Christiansen S., Boberg J., Axelstad M., Dalgaard M., Vinggaard A.M., Metzdorff S.B., Hass U. Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats. Reprod. Toxicol. 2010, 30:313-321.
6. David R.M., Gans G. Phthalate esters, Summary of mammalian toxicology and health effects of phthalate esters. The Handbook of Environmental Chemistry, Part 3Q 2003, 299-316. Springer Berlin Heidelberg.
7. Deneke S.M., Fanburg B.L. Regulation of cellular glutathione. Am. J. Physiol. 1989, 257:163-173.
8. Doumas B.T., Watson W.A., Biggs H.G. Albumin standards and the measurement of serum albumin with bromocresol green. Clin. Chim. Acta 1971, 31:87-96.
9. Ellman G.L., Courney K.D., Andres V., Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 1961, 7:75-88.
10. Eveillard A., Lasserre F., de Tayrac M., Polizzi A., Claus S., Canlet C., Mselli-Lakhal L., Gotardi G., Paris A., Guillou H., Martin P.G.P., Pineau T. Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach. Toxicol. Appl. Pharm. 2009, 236:282-292.
11. Gaudin R., Marsan P., Ndaw S., Robert A., Ducos P. Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: a field study. Int. Arch. Occup. Environ. Health 2011, 84:523-531.
12. Gavino V.C., Miller J.S., Ikharebha S.O., Milo G.E., Cornwall D.G. Effects of polyunsaturated fattyacids and antioxidants on lipid peroxidation in tissue cultures. J. Lipid Res. 1981, 22:763-769.
13. Grande S.W., Andrade A.J.M., Talsness C.E. A dose-response study following in utero and lactational exposure to di(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult female offspring rats. Toxicology 2007, 229:114-122.
14. Hernández A., Gómez M.A., Pena G., Gil F., Rodrigo L., Villanueva E., Pla A. Effect of long-term exposure to pesticides on plasma esterases from plastic greenhouse workers. J. Toxicol. Environ. Health, Part A 2004, 67:1095-1108.
15. Heudorf U., Mersch-Sundermann V., Angerer J. Phthalates: toxicology and exposure. Int. J. Hyg. Environ. Health 2007, 210:623-634.
16. Hines C.J., Hopf N.B.N., Deddens J.A., Calafat A.M., Silva M.J., Grote A.A., Sammons D.L. Urinary phthalate metabolite concentrations among workers in selected industries: a pilot biomonitoring study. Ann. Occup. Hyg. 2009, 53:1-17.
17. Kang Y., Man Y.B., Cheung K.C., Wong M.H. Risk assessment of human exposure to bioaccessible phthalate esters via indoor dust around the Pearl River Delta. Environ. Sci. Technol. 2012, 46:8422-8430.
18. Khan D.A., Hashmi I., Mahjabeen W., Naqvi T.A. Monitoring health implications of pesticide exposure in factory workers in Pakistan. Environ. Monit. Assess. 2010, 168:231-240.
19. Kingsley G.R. The direct Biuret method for the determination of serum proteinsas applied to photoelectric and visual colorimetry. J. Lab. Clin. Med. 1942, 27:840-845.
20. Koch H.M., Angerer J., Drexler H., Eckstein R., Weisbach V. Di(2-ethylhexyl)phthalate (DEHP) exposure of voluntary plasma and platelet donors. Int. J. Hyg. Environ. Health 2005, 208:489-498.
21. Koch H.M., Wittassek M., Brüning T., Angerer J., Heudorf U. Exposure to phthalates in 5-6years old primary school starters in Germany-a human biomonitoring study and a cumulative risk assessment. Int. J. Hyg. Environ. Health 2011, 214:188-195.
22. Kolarik B., Naydenov K., Larsson M., Bornehag C.G., Sundell J. The association between phthalates in dust and allergic diseases among Bulgarian children. Environ. Health Perspect. 2008, 116:98-103.
23. Latini G., De F.C., Presta G., Del V.A., Paris I., Ruggieri F., Mazzeo P. In utero exposure to di-(2-ethylhexyl) phthalate and duration of human pregnancy. Environ. Health Perspect. 2003, 111:1783-1785.
24. Liu L., Bao H., Liu F., Zhang J., Shen H. Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study. Environ. Int. 2011, 42:78-83.
25. Manno M., Viau C., Cocker J., Colosio C., Lowry L., Mutti A., Nordberg M., Wang S. Biomonitoring for occupational health risk assessment. Toxicol. Lett. 2010, 192:3-16.
26. Matsumoto M., Hirata-Koizumi M., Ema M. Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction. Regul. Toxicol. Pharm. 2008, 50:37-49.
27. Meeker J.D., Sathyanarayana S., Swan S.H. Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos. Trans. R. Soc. B 2009, 364:2097-2113.
28. Perry B.W., Doumas B.T., Bayse D.D. A candidate reference method for determination of bilirubin in plasma: test for transferability. Clin. Chem. 1983, 29:297-301.
29. Sampson E.J., Baird M.A. Chemical inhibition used in a kinetic urease/glutamate dehydrogenase method for urea in serum. Clin. Chem. 1979, 25:1721-1729.
30. Schumann G., Bonora R., Ceriotti F., Férard G., Ferrero C.A., Franck P.F., Gella F.J., Hoelzel W., Jørgensen P.J., Kanno T., Kessner A., Klauke R., Kristiansen N., Lessinger J.M., Linsinger T.P., Misaki H., Panteghini M., Pauwels J., Schiele F., Schimmel H.G., Weidemann G., Siekmann L. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37°C. International Federation of Clinical Chemistry and Laboratory Medicine. Part 6. Reference procedure for the measurement of catalytic concentration of gamma glutamyltransferase. Clin. Chem. Lab. Med. 2002, 40:734-738.
31. Spencer K. Analytical reviews in clinical biochemistry: the estimation of creatinine. Ann. Clin. Biochem. 1986, 23:1-25.
32. Staples C.A., Peterson D.R., Parkerton T.F., Adams W.J. The environmental fate of phthalate esters: a literature review. Chemosphere 1997, 35:667-749.
33. US EPA, 1981. Exposure and risk assessment for phthalate esters: di(2-ethylhexyl) phthalate, di-n-butyl phthalate, dimethyl phthalate, diethyl phthalate, di-n-octyl phthalate, butyl benzyl phthalate, final report. Washington, DC, USA Environmental Protection Agency (EPA-440/4-81-020).
34. Vermeulen R., Jönsson B.A.G., Lindh C.H., Kromhout H. Biological monitoring of carbon disulphide and phthalate exposure in the contemporary rubber industry. Int. Arch. Occup. Environ. Health 2005, 78:663-669.
35. Wang P., Wang S.L., Fan C.Q. Atmospheric distribution of particulate- and gas-phase phthalic esters (PAEs) in a Metropolitan City, Nanjing, East China. Chemosphere 2008, 72:1567-1572.
36. Wang W.X., Zhang Y.L., Wang S.L., Fan C.Q., Xu H. Distributions of phthalic esters carried by total suspended particulates in Nanjing, China. Environ. Monit. Assess. 2012, 184:6789-6798.
37. Wittassek M., Heger W., Koch H.M., Becker K., Angerer J., Kolossa-Gehring M. Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children-a comparison of two estimation models based on urinary DEHP metabolite levels. Int. J. Hyg. Environ. Health 2007, 210:35-42.
38. Wittassek M., Angerer J., Kolossa-Gehring M., Schäfer S.D., Klockenbusch W., Dobler L., Günsel A.K., Müller A., Wiesmüller G.A. Fetal exposure to phthalates-a pilot study. Int. J. Hyg. Environ. Health 2009, 212:492-498.