Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: A field study

International Archives of Occupational and Environmental Health

Volumn 84, Issue 5, 2011, Pages 523-531

  Gaudin, R ^a   Marsan, P ^a   Ndaw, S ^a   Robert, A ^a   Ducos, P ^a  

^a INSTITUT NATIONAL DE RECHERCHE ET DE SÉCURITÉ   (France)

Author keywords

Biological monitoring; DEHP; Metabolites; Occupational exposure

Indexed keywords

2 ETHYLHEXANOIC ACID; 2-ETHYLHEXANOIC ACID; DRUG DERIVATIVE; HEXANOIC ACID DERIVATIVE; MONO (2 ETHYLHEXYL)PHTHALATE; MONO(2 ETHYL 5 HYDROXYHEXYL) PHTHALATE; MONO(2-ETHYL-5-HYDROXYHEXYL) PHTHALATE; MONO-(2-ETHYLHEXYL)PHTHALATE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DERIVATIVE; PLASTICIZER;

ARTICLE; CHEMICAL INDUSTRY; ENVIRONMENTAL MONITORING; FEMALE; FRANCE; HUMAN; MALE; METHODOLOGY; OCCUPATIONAL EXPOSURE; URINE;

CHEMICAL INDUSTRY; DIETHYLHEXYL PHTHALATE; ENVIRONMENTAL MONITORING; FEMALE; FRANCE; HEXANOIC ACIDS; HUMANS; MALE; OCCUPATIONAL EXPOSURE; PHTHALIC ACIDS; PLASTICIZERS;

EID: 79956093827     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-010-0566-7     Document Type: Article

References (54)

1. PW Albro JR Hass CC Peck DG Odam JT Corbett FJ Bailey HE Blatt BB Barrett 1981 Identification of the metabolites of di-(2-ethylhexyl) phthalate in urine from the african-green monkey Drug Metab Dispos 9 223 225 1:CAS:528: DyaL3MXktlKmur8%3D (Pubitemid 11039418)
2. WA Anderson L Castle MJ Scotter RC Massey C Springall 2001 A biomarker approach to measuring human dietary exposure to certain phthalate diesters Food Addit Contam 18 12 1068 1074 10.1080/02652030110050113 1:CAS:528: DC%2BD3MXptVKmtL0%3D (Pubitemid 33107596)
3. LL Aylward SM Hays M Gagné K Krishnan 2009 Derivation of Biomonitoring equivalents for di(2-ethylhexyl) phthalate (CAS No 117-81-7) Regul Toxicol Pharmacol 55 249 258 10.1016/j.yrtph.2009.09.001 1:CAS:528: DC%2BD1MXhtlCgtrrJ
4. DB Barr MJ Silva K Kato JA Reidy NA Malek D Hurtz M Sadowski LL Needham AM Calafat 2003 Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers Environ Health Perspect 111 1148 1151 10.1289/ehp.6074 (Pubitemid 36939393)
5. BC Blount MJ Silva SP Caudill LL Needham JL Pirkle EJ Sampson GW Lucier RJ Jackson JW Brock 2000 Levels of seven urinary phthalate metabolites in a human reference population Environ Health Perspect 108 979 982 10.1289/ehp.00108979 1:CAS:528:DC%2BD3cXotVWrur4%3D
6. CG Bornehag J Sundell CJ Weschler T Sigsgaard B Lundgren M Hasselgren, et al. 2004 The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study Environ Health Perspect 112 1393 1397 10.1289/ehp.7187 1:CAS:528:DC%2BD2cXpsVGgs70%3D (Pubitemid 39386556)
7. Cadogan D (2006) European Council for plasticisers, intermediates Oslo 8-9 November
8. AM Calafat AR Slakman MJ Silva AR Herbert LL Needham 2004 Automated solid phase extraction and quantitative analysis of human milk for 13 phthalate metabolites J Chromatogr B 805 49 56 10.1016/j.jchromb.2004.02.006 1:CAS:528:DC%2BD2cXjsVWitbk%3D (Pubitemid 38534402)
9. F Chauvigné A Menuet L Lesné MC Chagnon C Chevrier JF Regnier J Angerer B Jégou 2009 Time-and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro Environ Health Perspect 117 4 515 521
10. CSTEE (Scientific Committee for Toxicity, Ecotoxicity and the Environment) (2000) 469 final
11. RM David 2000 Exposure to phthalate esters Environ Health Perspect 108 A440 10.1289/ehp.108-a440a 1:CAS:528:DC%2BD3cXotVWrtb0%3D
12. HA Dirven PH Van den Broek FJ Jongeneelen 1993 Determination of four metabolites of the plasticiser di(2-ethylhexyl) phthalate in human urine samples Int Arch Occup Environ Health 64 555 560 10.1007/BF00517700 1:CAS:528:DyaK2cXhtFGlsbg%3D (Pubitemid 23218122)
13. CJ Doelman PJ Born A Bast 1990 Plasticisers and bronchial hyperreactivity Lancet 335 8691 725 10.1016/0140-6736(90)90839-W 1:STN:280:DyaK3c7ptVWmtw%3D%3D (Pubitemid 20089337)
14. EU (2001) Risk assessment bis(2-ethylhexyl) phthalate (DEHP). Human Health-National Chemicals Inspectorate. Solna, Sweden, Consolidated final report
15. EU (2008) European chemicals Bureau 2nd priority list vol 80. Risk assessment bis(2-ethylhexyl) phthalate (DEHP). Final report, Sweden
16. R Gaudin P Marsan A Robert, et al. 2008 Biological monitoring of occupational exposure to di(2-ethylhexyl) phthalate: survey of workers exposed to plastisols Int Arch Occup Environ Health 81 959 966 10.1007/s00420-007-0289-6 1:CAS:528:DC%2BD1cXmsVejur8%3D
17. Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz (2007) 50(2):249-250
18. R Hauser AM Calafat 2005 Phthalates and human health Occup Environ Med 62 806 818 10.1136/oem.2004.017590 1:CAS:528:DC%2BD2MXht1Ggsr3E (Pubitemid 41565017)
19. U Heudorf V Mersch-Sundermann J Angerer 2007 Phthalates: toxicology and exposure Int J Hyg Environ Health 210 5 623 634 10.1016/j.ijheh.2007.07.011 1:CAS:528:DC%2BD1cXkslCisw%3D%3D (Pubitemid 47539285)
20. CJ Hines NB Nilsen Hopf JA Deddens AM Calafat MJ Silva AA Grote Sammons 2009 DL urinary phthalate metabolite concentrations among workers in selected industries: a pilot biomonitoring study Ann Occup Hyg 53 1 1 17 10.1093/annhyg/men066 1:CAS:528:DC%2BD1MXhtVegtrw%3D
21. J Högberg J Hanberg M Berglund S Skerfving M Remberger AM Calafat, et al. 2008 Phthalate diesters and their metabolites in human breast milk, blood and urine as biomarkers of exposure in vulnerable populations Environ Health Perspect 116 334 339 10.1289/ehp.116-a334 (Pubitemid 351395601)
22. IARC (2000) Monographs on the evaluation of carcinogenic risks to humans, Some Industrial Chemicals, Lyon, pp 41-148
23. K Kato MJ Silva JA Reidy D Hurtz NA Malek LL Needham H Nakazawa DB Barr AM Calafat 2004 Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono(2-ethyl-5- oxohexyl) phthalate as biomarkers for human exposure assessment to di(2-ethylhexyl) phthalate Environ Health Perspect 112 327 330 10.1289/ehp.6663 1:CAS:528:DC%2BD2cXislaqt7c%3D (Pubitemid 38351395)
24. HM Koch LM Gonzalez-Reche J Angerer 2003 On-line clean-up by multidimensional liquid chromatography-electrospray ionization tandem mass spectrometry for high throughput quantification of primary and secondary phthalate metabolites in human urine J Chromatogr B 784 169 182 10.1016/S1570-0232(02)00785-7 1:CAS:528:DC%2BD3sXhtFyqur0%3D (Pubitemid 36009353)
25. HM Koch B Rossbach H Drexler J Angerer 2003 Internal exposure of the general population to DEHP and other phthalates-determination of secondary and primary phthalate monoester metabolites in urine Environ Res 93 177 185 10.1016/S0013-9351(03)00083-5 1:CAS:528:DC%2BD3sXntVGls70%3D (Pubitemid 37083327)
26. HM Koch HM Bolt J Angerer 2004 Di(2-ethylhexyl) phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP Arch Toxicol 78 123 130 10.1007/s00204-003-0522-3 1:CAS:528:DC%2BD2cXitFCms74%3D (Pubitemid 38657193)
27. HM Koch HM Bolt R Preuss J Angerer 2005 New metabolites of di(2- ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP Arch Toxicol 79 367 376 10.1007/s00204-004-0642-4 1:CAS:528:DC%2BD2MXmsVOqsL0%3D (Pubitemid 41040172)
28. MC Kohn F Parham SA Masten CJ Portier MD Shelby JW Brock LL Needham 2000 Human exposure estimates exposure to phthalate Environ Health Perspect 108 A440 A442 10.1289/ehp.108-a440b 1:CAS:528:DC%2BD3cXotVWrtbo%3D
29. R Lambrot V Muczynski C Lécureuil G Angenard H Coffigny C Pairault, et al. 2009 Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production Environ Health Perspect 117 32 37 1:CAS:528:DC%2BD1MXhvV2nt74%3D
30. G Latini 2005 Monitoring phthalate exposure in humans Clin Chim Acta 361 1-2 20 29 10.1016/j.cccn.2005.05.003 1:CAS:528:DC%2BD2MXhtVGrsLbI (Pubitemid 41382607)
31. KM Main GK Mortensen MM Kaleva KA Boisen IN Damgaard M Chellakooty, et al. 2006 Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age Environ Health Perspect 114 270 276 10.1289/ehp.8075 1:CAS:528:DC%2BD28XitVWhs7Y%3D (Pubitemid 43193651)
32. JD Meeker AM Calafat R Hauser 2007 Di-(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men Environ Health Perspect 115 1029 1034 10.1289/ehp.9852 1:CAS:528:DC%2BD2sXosFSjsr0%3D (Pubitemid 47317067)
33. RL Melnick 2001 Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl) phthalate (DEHP)? Environ Health Perspect 109 437 442 10.1289/ehp.01109437 1:CAS:528:DC%2BD3MXkslGqsLg%3D (Pubitemid 32998799)
34. LE Milkov MV Aldyreva TB Popova KA Lopukhova YL Makarenko LM Malyar TK Shakhova 1973 Health status of workers exposed to phthalate plasticizers in the manufacture of artificial leather and films based on PVC resins Environ Health Perspect 3 175 178 1:STN:280:DyaE3s7nslaisA%3D%3D
35. GK Mortensen KM Main AM Andersson H Leffers NE Skakkebaek 2005 Determination of phthalate monoesters in human milk, consumer milk, and infant formula by tandem mass spectrometry (LC-MS-MS) Anal Bioanal Chem 382 4 1084 1092 10.1007/s00216-005-3218-0 1:CAS:528:DC%2BD2MXlsFGms78%3D (Pubitemid 40890969)
36. J Nielsen B Åkesson S Skerfving 1985 Phthalate ester exposure-air levels and health of workers processing polyvinylchloride Am Ind Hyg Assoc J 46 643 647 1:CAS:528:DyaL28XhtFGhurs%3D (Pubitemid 16200605)
37. NTP-CERHR (2000) Expert Panel Report on Di(2-ethylhexyl) phthalate, Research Triangle Park, NC
38. L Oie LG Hersoug JO Madsen 1997 Residential exposure to plasticizers and its possible role in the pathogenesis of asthma Environ Health Perspect 105 972 978 10.1289/ehp.97105972 1:CAS:528:DyaK2sXnslylur4%3D (Pubitemid 27503630)
39. G Pan T Hanaoka M Yoshimura S Zhang P Wang H Tsukino, et al. 2006 Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China Environ Health Perspect 114 1643 1648 1:CAS:528:DC%2BD28XhtlWnurfL (Pubitemid 44718267)
40. CC Peck PW Albro 1982 Toxic potential of the plasticizer di(2-ethylhexyl) phthalate in the context of its disposition and metabolism in primates and man Environ Health Perspect 45 11 17 1:CAS:528:DyaL3sXosVeqsQ%3D%3D (Pubitemid 13223094)
41. R Preuss HM Koch J Angerer 2005 Biological monitoring of the five major metabolites of di-(2-ethylhexyl) phthalate (DEHP) in human urine using column-switching liquid chromatography-tandem mass spectrometry J Chromatogr B 816 269 280 10.1016/j.jchromb.2004.11.048 1:CAS:528:DC%2BD2MXmvFahtg%3D%3D (Pubitemid 40143514)
42. P Schmid C Schlatter 1985 Excretion and metabolism of di(2-ethylhexyl) phthalate in man Xenobiotica 15 251 256 10.3109/00498258509045356 1:CAS:528:DyaL2MXks1Khsrk%3D (Pubitemid 15050134)
43. MJ Silva NA Malek CC Hodge JA Reidy K Kato DB Barr LL Needham JW Brock 2003 Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry J Chromatogr B 789 393 404 10.1016/S1570-0232(03)00164- 8 1:CAS:528:DC%2BD3sXjsVGht7c%3D (Pubitemid 36549208)
44. MJ Silva DB Barr JA Reidy NA Malek CC Hodge SP Caudill, et al. 2004 Urinary levels of seven phthalate metabolites in the US population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 Environ Health Perspect 112 331 338 10.1289/ehp.6723 1:CAS:528:DC%2BD2cXislaqtL4%3D (Pubitemid 38351396)
45. MJ Silva JA Reidy AR Herbert JL Preau Jr LL Needham AM Calafat 2004 Detection of phthalate metabolites in human amniotic fluid Bull Environ Contam Toxicol 72 1226 1231 10.1007/s00128-004-0374-4 1:CAS:528:DC%2BD2cXkvVyltrs%3D (Pubitemid 38691464)
46. MJ Silva JA Reidy JL Preau E Samandar LL Needham AM Calafat 2006 Measurement of eight metabolites of di(2-ethylhexyl) phthalate as biomarkers for human exposure assessment Biomarkers 11 1 1 13 10.1080/13547500500382868 1:CAS:528:DC%2BD28XhsVSks7c%3D (Pubitemid 43250548)
47. AM Thiess I Fleig 1978 Chromosomenuntersuchungen bei Mitarbeitern mit Exposition gegenüber Di-2-äthylhexylphthalat (DOP) Zbl Arbeitsmed 12 351 355
48. Ullmann's Encyclopedia of industrial chemistry (2002)
49. R Vermeulen BAG Jönsson CH Lindh, et al. 2005 Biological monitoring of carbon disulphide and phthalate exposure in the contemporary rubber industry Int Arch Occup Environ Health 78 663 669 10.1007/s00420-005-0017-z 1:CAS:528:DC%2BD2MXhtFCqsr%2FO (Pubitemid 41644386)
50. HG Wahl Q Hong D Stübe ME Maier HU Häring HM Liebich 2001 Simultaneous analysis of the di(2-ethylhexyl) phthalate metabolites, 2-ethylhexanoic acid, 2-ethyl-3-hydroxyhexanoic acid and 2-ethyl-3-oxohexanoic acid in urine by gas chromatography-mass spectrometry J Chromatogr B 758 213 219 10.1016/S0378-4347(01)00183-9 1:STN:280:DC%2BD3MvktVGkug%3D%3D (Pubitemid 32536734)
51. M Wittassek J Angerer 2009 Phthalates: metabolisme and exposure Int J Androl 31 131 138 10.1111/j.1365-2605.2007.00837.x
52. M Wittassek GA Wiesmuller HM Koch R Eckard L Dobler J Muller J Angerer C Schlüter 2007 Internal phthalate exposure over the last two decades-a retrospective human biomonitoring study Int J Hyg Environ Health 210 3-4 319 333 10.1016/j.ijheh.2007.01.037 1:CAS:528:DC%2BD2sXnsVKitLg%3D (Pubitemid 46618121)
53. M Wittassek J Angerer M Kolossa-Gehring SD Schäfer W Klockenbusch L Dobler AK Günsel A Müller GA Wiesmüller 2009 Fetal exposure to phthalates - a pilot study Int J Hyg Environ Health 212 5 492 498 10.1016/j.ijheh.2009.04.001 1:CAS:528:DC%2BD1MXhtF2ktL3N
54. Wolfe GW, Layton KA (2003) Multigeneration reproduction toxicity study in rats: multigenerational reproductive assessment by continuous breeding when administered to Sprague-Dawley rats in the diet. TRC Study No. 7244-200. Therimmune Research Corporation, Maryland