Suppression of alpha-tocopherol ether-linked acetic acid in VEGF-induced angiogenesis and the possible mechanisms in human umbilical vein endothelial cells

Toxicology and Applied Pharmacology

Volumn 281, Issue 3, 2014, Pages 310-316

  Chuang, Cheng Hung ^a   Liu, Chia Hua ^b   Lu, Ta Jung ^b   Hu, Miao Lin ^b  

^a HUNGKUANG UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Cell invasion; Cell migration; Human umbilical vein endothelial cells; Matrix metalloproteinase 2; Vascular endothelial growth factor; Tocopherol ether linked acetic acid

Indexed keywords

ALPHA TOCOPHEROL; BETA ACTIN; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TISSUE INHIBITOR OF METALLOPROTEINASE 2; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; 2,5,7,8-TETRAMETHYL-2R-(4R,8R,12-TRIMETHYLTRIDECYL)CHROMAN-6-YLOXY ACETIC ACID; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC ANTIMETABOLITE; FOCAL ADHESION KINASE 1; MMP2 PROTEIN, HUMAN; NME1 PROTEIN, HUMAN; NUCLEOSIDE DIPHOSPHATE KINASE NM23; PTK2 PROTEIN, HUMAN; TOCOPHEROL; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; PHENOTYPE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; ZYMOGRAPHY; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL ADHESION; CELL CULTURE; CELL MOTION; CHEMISTRY; CHICK EMBRYO; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FOCAL ADHESION KINASE 1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; NEOVASCULARIZATION, PATHOLOGIC; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; TOCOPHEROLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84912020734     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.10.018     Document Type: Article

References (36)

1. Bao S., Wu Q., Sathornsumetee S., Hao Y., Li Z., et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 2006, 66:7843-7848.
2. Basire A., Sabatier F., Ravet S., Lamy E., Mialhe A., et al. High urokinase expression contributes to the angiogenic properties of endothelial cells derived from circulating progenitors. Thromb. Haemost. 2006, 95:678-688.
3. Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
4. Chen H., Yan X., Lin J., Wang F., Xu W. Depolymerized products of lambda-carrageenan as a potent angiogenesis inhibitor. J. Agric. Food Chem. 2007, 55:6910-6917.
5. Chen J.S., Huang X.H., Wang Q., Chen X.L., Fu X.H., et al. FAK is involved in invasion and metastasis of hepatocellular carcinoma. Clin. Exp. Metastasis 2010, 27:71-82.
6. Chen Q., Wang Y., Xu K., Lu G., Ying Z., et al. Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Oncol. Rep. 2010, 23:397-403.
7. Chen W., Park S.K., Yu W., Xiong A., Sanders B.G., et al. Synthesis and screening of novel vitamin E derivatives for anticancer functions. Eur. J. Med. Chem. 2012, 58:72-83.
8. Cheng S., Alfonso-Jaume M.A., Mertens P.R., Lovett D.H. Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Biochem. J. 2002, 366:807-816.
9. Chirco R., Liu X.W., Jung K.K., Kim H.R. Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev. 2006, 25:99-113.
10. Chuang C.H., Hu M.L. l-Carnosine inhibits metastasis of SK-Hep-1 cells by inhibition of matrix metaoproteinase-9 expression and induction of an antimetastatic gene, nm23-H1. Nutr. Cancer 2008, 60:526-533.
11. Chuang C.H., Huang C.S., Hu M.L. Vitamin E and rutin synergistically inhibit expression of vascular endothelial growth factor through down-regulation of binding activity of activator protein-1 in human promyelocytic leukemia (HL-60) cells. Chem. Biol. Interact. 2010, 183:434-441.
12. Ferrara N. VEGF as a therapeutic target in cancer. Oncology 2005, 69:11-16.
13. Folkman J. What is the evidence that tumors are angiogenesis dependent?. J. Natl. Cancer Inst. 1990, 82:4-6.
14. Folkman J. Angiogenesis. Annu. Rev. Med. 2006, 57:1-18.
15. Hahn T., Bradley-Dunlop D.J., Hurley L.H., Von-Hoff D., Gately S., et al. The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer. BMC Cancer 2011, 11:471.
16. Hidalgo M., Eckhardt S.G. Development of matrix metalloproteinase inhibitors in cancer therapy. J. Natl. Cancer Inst. 2001, 93:178-193.
17. Hwang H.J., Park H.J., Chung H.J., Min H.Y., Park E.J., et al. Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells. J. Nutr. Biochem. 2006, 17:356-362.
18. Kim S.H., Kim J. Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK. Biochim. Biophys. Acta 2006, 1763:823-832.
19. Lawson K.A., Anderson K., Simmons-Menchaca M., Atkinson J., Sun L., et al. Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis. Mol. Cancer Ther. 2003, 2:437-444.
20. Lee J.H., Choi S., Lee Y., Lee H.J., Kim K.H., et al. Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades. Mol. Cancer Ther. 2010, 9:389-399.
21. Li L., Braiteh F.S., Kurzrock R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 2005, 104:1322-1331.
22. Li F., Li C., Zhang H., Lu Z., Li Z., et al. VI-14, a novel flavonoid derivative, inhibits migration and invasion of human breast cancer cells. Toxicol. Appl. Pharmacol. 2012, 261:217-226.
23. Mentlein R., Held-Feindt J. Angiogenesis factors in gliomas-a new key to tumour therapy?. Naturwissenschaften 2003, 90:385-394.
24. Ohba K., Miyata Y., Koga S., Kanda S., Kanetake H. Expression of nm23-H1 gene product in sarcomatous cancer cells of renal cell carcinoma: correlation with tumor stage and expression of matrix metalloproteinase-2, matrix metalloproteinase-9, sialyl Lewis X, and c-erbB-2. Urology 2005, 65:1029-1034.
25. Omar H.A., Arafa E.S.A., Salama S.A., Arab H.H., Wu C.H., et al. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways. Toxicol. Appl. Pharmacol. 2013, 272:616-624.
26. Ramer R., Eichele K., Hinz B. Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells. Oncogene 2007, 26:5822-5827.
27. Sasaki T., Tanno S., Shibukawa K., Osanai S., Kawabe J., et al. Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts. Int. J. Oncol. 2008, 33:525-532.
28. Shun M.C., Yu W., Gapor A., Parsons R., Atkinson J., et al. Pro-apoptotic mechanisms of action of a novel vitamin E analog (α-TEA) and a naturally occurring form of vitamin E (δ-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr. Cancer 2004, 48:95-105.
29. Stetler-Stevenson W.G. Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. J. Clin. Invest. 1999, 103:1237-1241.
30. Tiwary R., Yu W., Sanders B.G., Kline K. α-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways. Br. J. Cancer 2011, 104:101-109.
31. Tsuzuki T., Shibata A., Kawakami Y., Nakagawa K., Miyazawa T. Conjugated eicosapentaenoic acid inhibits vascular endothelial growth factor-induced angiogenesis by suppressing the migration of human umbilical vein endothelial cells. J. Nutr. 2007, 137:641-646.
32. Weis S.M., Cheresh D.A. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med. 2011, 17:1359-1370.
33. Yu W., Tiwary R., Li J., Park S.K., Jia L., et al. α-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway. Mol. Carcinog. 2010, 49:964-973.
34. Zeng H., Dvorak H.F., Mukhopadhyay D. Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways. J. Biol. Chem. 2001, 276:26969-26979.
35. Zhang S., Lawson K.A., Simmons-Menchaca M., Sun L., Sanders B.G., et al. Vitamin E analog α-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice. Breast Cancer Res. Treat. 2004, 87:111-121.
36. Zhao J., Guan J.L. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev. 2009, 28:35-49.