Establishment of a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors

Journal of Pharmacological and Toxicological Methods

Volumn 71, Issue , 2015, Pages 8-12

  Huan, Yi ^a   Jiang, Qian ^a   Liu, Jing long ^a   Shen, Zhu fang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cell model; Dipeptidyl peptidases; Inhibitors; Selectivity

Indexed keywords

ALOGLIPTIN; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 8; DIPEPTIDYL PEPTIDASE 9; DIPEPTIDYL PEPTIDASE IV INHIBITOR; LINAGLIPTIN; SAXAGLIPTIN; SITAGLIPTIN; UNCLASSIFIED DRUG; VILDAGLIPTIN; ADAMANTANE; DIPEPTIDASE; DIPEPTIDE; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; DPP8 PROTEIN, HUMAN; DPP9 PROTEIN, HUMAN; ENZYME INHIBITOR; NITRILE; PYRROLIDINE DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SUBSTRATE; EX VIVO STUDY; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC50; PREVALENCE; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; BIOLOGICAL MODEL; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; STRUCTURE ACTIVITY RELATION;

ADAMANTANE; CELL SURVIVAL; DIPEPTIDASES; DIPEPTIDES; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; MODELS, BIOLOGICAL; NITRILES; PYRROLIDINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84912018828     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2014.11.002     Document Type: Article

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