CD4+Foxp3+ Tregs protect against innate immune cell-mediated fulminant hepatitis in mice

Molecular Immunology

Volumn 63, Issue 2, 2015, Pages 420-427

  Hou, Xin ^a   Song, Jing ^a   Su, Jun ^a   Huang, Dake ^a   Gao, Wenda ^b   Yan, Jun ^c   Shen, Jijia ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b Antagen Institute for Biomedical Research   (United States)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

IL 10; Innate immune; Liver injury; TGF ; Treg

Indexed keywords

GALACTOSAMINE; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; CD4 ANTIGEN; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR ALPHA; POLYINOSINIC POLYCYTIDYLIC ACID; PROTECTIVE AGENT;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEPATITIS; IMMUNOCOMPETENT CELL; IN VITRO STUDY; INNATE IMMUNITY; KUPFFER CELL; LIVER INJURY; LYMPHOCYTE DEPLETION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; ANIMAL; C57BL MOUSE; DRUG EFFECTS; IMMUNOLOGY; INJECTION; LIVER; METABOLISM; PATHOLOGY;

MUS;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD4; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; GALACTOSAMINE; HEPATITIS; IMMUNITY, INNATE; INJECTIONS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KUPFFER CELLS; LIVER; LYMPHOCYTE DEPLETION; MALE; MICE, INBRED C57BL; POLY I-C; PROTECTIVE AGENTS; T-LYMPHOCYTES, REGULATORY;

EID: 84912017652     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2014.09.015     Document Type: Article

References (41)

1. Antunes I., Kassiotis G. Suppression of innate immune pathology by regulatory T cells during Influenza A virus infection of immunodeficient mice. J. Virol. 2010, 84:12564-12575.
2. Belkaid Y., Rouse B.T. Natural regulatory T cells in infectious disease. Nat. Immunol. 2005, 6:353-360.
3. Bergmann C., Wild C.A., Narwan M., Lotfi R., Lang S., Brandau S. Human tumor-induced and naturally occurring Treg cells differentially affect NK cells activated by either IL-2 or target cells. Eur. J. Immunol. 2011, 41:3564-3573.
4. Bertoletti A., Maini M., Williams R. Role of hepatitis B virus specific cytotoxic T cells in liver damage and viral control. Antiviral Res. 2003, 60:61-66.
5. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
6. Bieghs V., Trautwein C. The innate immune response during liver inflammation and metabolic disease. Trends Immunol. 2013, 34:446-452.
7. + Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007, 110:1225-1232.
8. Cai L., Zhang Z., Zhou L., Wang H., Fu J., Zhang S., Shi M., Zhang H., Yang Y., Wu H., Tien P., Wang F.S. Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients. Clin. Immunol. 2008, 129:428-437.
9. + Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J. Clin. Investig. 2009, 119:2898-2913.
10. E X.Q., Meng H.X., Cao Y., Zhang S.Q., Bi Z.G., Yamakawa M. Distribution of regulatory T cells and interaction with dendritic cells in the synovium of rheumatoid arthritis. Scand. J. Rheumatol. 2012, 41:413-420.
11. Erhardt A., Biburger M., Papadopoulos T., Tiegs G. IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice. Hepatology 2007, 45:475-485.
12. Fallarino F., Grohmann U., Hwang K.W., Orabona C., Vacca C., Bianchi R., Belladonna M.L., Fioretti M.C., Alegre M.L., Puccetti P. Modulation of tryptophan catabolism by regulatory T cells. Nat. Immunol. 2003, 4:1206-1212.
13. Gao B., Jeong W.I., Tian Z. Liver: an organ with predominant innate immunity. Hepatology 2008, 47:729-736.
14. + regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J. Exp. Med. 2005, 202:1075-1085.
15. + T cell subsets; differences between naive and antigen specific T regulatory cells. Curr. Opin. Immunol. 2011, 23:641-647.
16. Hong G.U., Kim N.G., Jeoung D., Ro J.Y. Anti-CD40 Ab- or 8-oxo-dG-enhanced Treg cells reduce development of experimental autoimmune encephalomyelitis via down-regulating migration and activation of mast cells. J. Neuroimmunol. 2013, 260:60-73.
17. Hou X., Zhou R., Wei H., Sun R., Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology 2009, 49:940-949.
18. Hua J., Liang S., Ma X., Webb T.J., Potter J.P., Li Z. The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity. PLoS ONE 2011, 6:e27038.
19. Jenabian M.A., Seddiki N., Yatim A., Carriere M., Hulin A., Younas M., Ghadimi E., Kok A., Routy J.P., Tremblay A., Sevigny J., Lelievre J.D., Levy Y. Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection. PLoS Pathog. 2013, 9:e1003319.
20. Jin Z., Sun R., Wei H., Gao X., Chen Y., Tian Z. Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. Hepatology 2011, 53:219-229.
21. Liang B., Workman C., Lee J., Chew C., Dale B.M., Colonna L., Flores M., Li N., Schweighoffer E., Greenberg S., Tybulewicz V., Vignali D., Clynes R. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J. Immunol. 2008, 180:5916-5926.
22. + T cells in mice. Immunol. Cell Biol. 2011, 89:130-142.
23. + regulatory T cells in gastric cancer. Int. J. Cancer 2008, 122:2286-2293.
24. + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:10113-10118.
25. Orentas R.J., Kohler M.E., Johnson B.D. Suppression of anti-cancer immunity by regulatory T cells: back to the future. Semin. Cancer Biol. 2006, 16:137-149.
26. Qureshi O.S., Zheng Y., Nakamura K., Attridge K., Manzotti C., Schmidt E.M., Baker J., Jeffery L.E., Kaur S., Briggs Z., Hou T.Z., Futter C.E., Anderson G., Walker L.S., Sansom D.M. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (New York, NY) 2011, 332:600-603.
27. + regulatory T cells abrogates their function in vivo. J. Immunol. 2006, 177:4376-4383.
28. + regulatory T cells in the human immune system. Nat. Rev. 2010, 10:490-500.
29. Schmetterer K.G., Neunkirchner A., Pickl W.F. Naturally occurring regulatory T cells: markers, mechanisms, and manipulation. FASEB J. 2012, 26:2253-2276.
30. Schmitz I., Schneider C., Frohlich A., Frebel H., Christ D., Leonard W.J., Sparwasser T., Oxenius A., Freigang S., Kopf M. IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog. 2013, 9:e1003362.
31. Shafiani S., Dinh C., Ertelt J.M., Moguche A.O., Siddiqui I., Smigiel K.S., Sharma P., Campbell D.J., Way S.S., Urdahl K.B. Pathogen-specific Treg cells expand early during Mycobacterium tuberculosis infection but are later eliminated in response to interleukin-12. Immunity 2013, 38:1261-1270.
32. Sharir R., Semo J., Shaish A., Landa-Rouben N., Entin-Meer M., Keren G., George J. Regulatory T cells influence blood flow recovery in experimental hindlimb ischemia in an IL-10 dependent manner. Cardiovasc. Res. 2014, 103:585-596.
33. + T regulatory cell-mediated suppression. Immunity 2009, 30:636-645.
34. Sojka D.K., Fowell D.J. Regulatory T cells inhibit acute IFN-gamma synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:18336-18341.
35. + T-cell lymphopenia-induced proliferation. Eur. J. Immunol. 2009, 39:1544-1551.
36. Stewart C.A., Metheny H., Iida N., Smith L., Hanson M., Steinhagen F., Leighty R.M., Roers A., Karp C.L., Muller W., Trinchieri G. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J. Clin. Investig. 2013, 123:4859-4874.
37. + regulatory T cells induce alternative activation of human monocytes/macrophages. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:19446-19451.
38. Walker L.S. Treg and CTLA-4: two intertwining pathways to immune tolerance. J. Autoimmun. 2013, 45:49-57.
39. + regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. J. Immunol. 2008, 181:7221-7229.
40. + regulatory T cell function. Science 2008, 322:271-275.
41. Zhou H., Chen L., You Y., Zou L., Zou P. Foxp3-transduced polyclonal regulatory T cells suppress NK cell functions in a TGF-beta dependent manner. Autoimmunity 2009, 43:299-307.