Role of hepatitis B virus specific cytotoxic T cells in liver damage and viral control

Antiviral Research

Volumn 60, Issue 2, 2003, Pages 61-66

  Bertoletti, A ^a   Maini, M ^a   Williams, Roger ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

CD8 cells; HBV

Indexed keywords

CD8 ANTIGEN; HLA ANTIGEN; PEPTIDE; TETRAMER;

CELL INFILTRATION; CLINICAL ARTICLE; CONFERENCE PAPER; CYTOTOXICITY; HEPATITIS; HEPATITIS B VIRUS; HUMAN; IMMUNOPATHOLOGY; INFECTION CONTROL; LIVER INJURY; PRIORITY JOURNAL; T LYMPHOCYTE; VIREMIA; VIRUS IDENTIFICATION; VIRUS INHIBITION; VIRUS REPLICATION;

HEPATITIS B VIRUS;

EID: 0345306198     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2003.08.012     Document Type: Conference Paper

References (6)

1. Ando K., Moriyama T., Guidotti L.G., Wirth S., Schreiber R.D., Schlicht H.J., Huang S.N., Chisari F.V. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J. Exp. Med. 178:1993;1541-1554.
2. Bertoletti A., Maini M.K. Protection or damage: a dual role of virus-specific CD8 cells during HBV and HCV infections? Curr. Opin. Immunol. 12:2000;403-408.
3. Guidotti L.G., Chisari F.V. To kill or to cure: options in host defence against viral infection. Curr. Opin. Immunol. 8:1986;478-483.
4. Guidotti L.G., Rochford R., Chung J., Shapiro M., Purcell R., Chisari F.V. Viral clearance without destruction of infected cells during acute HBV infection. Science. 284:1999;825-829.
5. + cells in liver damage and viral control during persistent hepatitis B virus infection. J. Exp. Med. 191:2000;1269-1280.
6. Nowak M.A., Bangham C.R. Population dynamics of immune responses to persistent viruses. Science. 272:1996;74-79.