Δf508-CFTR correctors: Synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 24, 2014, Pages 5840-5844

  Ye, Long ^a   Hu, Bao ^a   El Badri, Faris ^b   Hudson, Brandi M ^b   Phuan, Puay Wah ^c,d   Verkman, A S ^c,d   Tantillo, Dean J ^b   Kurth, Mark J ^b  

^a WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

C,C linked bisazoles; Correctors; Cystic fibrosis; Transmembrane regulator

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; IMIDAZOLE DERIVATIVE; OXADIAZOLE DERIVATIVE; OXAZOLE DERIVATIVE; THIADIAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR DELTA F508; IMIDAZOLONE; PROTEIN BINDING; WATER;

ARTICLE; BROMINATION; DRUG BINDING SITE; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; ELECTRON; HYDROPHILICITY; MICROWAVE IRRADIATION; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; CHEMISTRY; CONFORMATION; CYSTIC FIBROSIS; HUMAN; KINETICS; METABOLISM; PATHOLOGY; THERMODYNAMICS;

CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; IMIDAZOLES; KINETICS; MOLECULAR CONFORMATION; OXADIAZOLES; OXAZOLES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; THIADIAZOLES; THIAZOLES; WATER;

EID: 84912000365     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.09.067     Document Type: Article

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