Constrained bithiazoles: Small molecule correctors of defective δf508-CFTR protein trafficking

Journal of Medicinal Chemistry

Volumn 57, Issue 15, 2014, Pages 6729-6738

  Coffman, Keith C ^a   Nguyen, Huy H ^a   Phuan, Puay Wah ^b   Hudson, Brandi M ^a   Yu, Gui J ^a   Bagdasarian, Alex L ^a   Montgomery, Deanna ^a   Lodewyk, Michael W ^a   Yang, Baoxue ^b   Yoo, Choong L ^a   Verkman, A S ^b   Tantillo, Dean J ^a   Kurth, Mark J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE MUSTARD DERIVATIVE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; METHYL 4 [[ 8 (( 5 CHLORO 2 METHOXYPHENYL)AMINO) 5,6 DIHYDRO 4H CYCLOHEPTA[1,2 D:3,4 D']BIS(THIAZOLE) 2 YL]AMINO] 4 OXOBUTANOIC ACID; N [ 9 [( 5 CHLORO 2 METHOXYPHENYL)AMINO] 4,5,6,7 TETRAHYDROCYCLOOCTA[1,2 D:3,4 D']BIS(THIAZOLE) 2 YL]ISOBUTYRAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; CYCLOHEPTANE DERIVATIVE; CYCLOOCTANE DERIVATIVE; METHYL 4-((8-((5-CHLORO-2-METHOXYPHENYL)AMINO)-5,6-DIHYDRO-4H-CYCLOHEPTA(1,2-D-3,4-D′)BIS(THIAZOLE)-2-YL)AMINO)-4-OXOBUTANOATE; N-(9-((5-CHLORO-2-METHOXYPHENYL)AMINO)-4,5,6,7-TETRAHYDROCYCLOOCTA(1,2-D-3,4-D′)BIS(THIAZOLE)-2-YL)ISOBUTYRAMIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; EPITHELIUM CELL; IC 50; IN VITRO STUDY; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN TRANSPORT; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MUTATION; RAT; SYNTHESIS; THYROID GLAND;

ANIMALS; CELLS, CULTURED; CYCLOHEPTANES; CYCLOOCTANES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; HUMANS; MUTATION; PROTEIN TRANSPORT; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THYROID GLAND;

EID: 84906081074     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5007885     Document Type: Article

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