Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice

Mammalian Genome

Volumn 25, Issue 11-12, 2014, Pages 549-563

  Spiezio, Sabrina H ^a   Amon, Lynn M ^b   McMillen, Timothy S ^c   Vick, Cynthia M ^c   Houston, Barbara A ^c   Caldwell, Mark ^c   Ogimoto, Kayoko ^c   Morton, Gregory J ^c   Kirk, Elizabeth A ^d   Schwartz, Michael W ^c   Nadeau, Joseph H ^e   LeBoeuf, Renée C ^c  

^a INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d BASTYR UNIVERSITY   (United States)

^e PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BODY COMPOSITION; BODY WEIGHT; CHROMOSOME SUBSTITUTION STRAIN; CONTROLLED STUDY; DNA MODIFICATION; ENERGY BALANCE; ENERGY EXPENDITURE; ENERGY METABOLISM; FEMALE; FOOD INTAKE; GENE IDENTIFICATION; GENETIC REGULATION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HEREDITY; LIPID BLOOD LEVEL; MALE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CHROMOSOME; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; LIPID DIET;

MUS;

ANIMALS; ATHEROSCLEROSIS; BODY COMPOSITION; BODY WEIGHT; CHROMOSOMES, MAMMALIAN; DIET, HIGH-FAT; ENERGY METABOLISM; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; MALE; MICE, INBRED C57BL; OBESITY; PHENOTYPE; QUANTITATIVE TRAIT LOCI;

EID: 84911999997     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-014-9530-2     Document Type: Article

References (69)

1. Ackert-Bicknell C, Paigen B, Korstanje R (2013) Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis. J Lipid Res 54:984–994
2. Ajioka RS, LeBoeuf RC, Gillespie RR, Amon LM, Kushner JP (2007) Mapping genes responsible for strain-specific iron phenotypes in murine chromosome substitution strains. Blood Cells Mol Dis 39:199–205
3. Bennett BJ, Orozco L, Kostem E, Erbilgin A, Dallinga M, Neuhaus I, Guan B, Wang X, Eskin E, Lusis AJ (2012) High-resolution association mapping of atherosclerosis loci in mice. Arterioscler Thromb Vasc Biol 32:1790–1798
4. Buchner DA, Burrage LC, Hill AE, Yazbek SN, O’Brien WE, Croniger CM, Nadeau JH (2008) Resistance to diet-induced obesity in mice with a single substituted chromosome. Physiol Genomics 35:116–122
5. Burrage LC, Baskin-Hill AE, Sinasac DS, Singer JB, Croniger CM, Kirby A, Kulbokas EJ, Daly MJ, Lander ES, Broman KW, Nadeau JH (2010) Genetic resistance to diet-induced obesity in chromosome substitution strains of mice. Mamm Genome 21:115–129
6. Castellani LW, Weinreb A, Bodnar J, Goto AM, Doolittle M, Mehrabian M, Demant P, Lusis AJ (1998) Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet 18:374–377
7. Chen Y, Rollins J, Paigen B, Wang X (2007) Genetic and genomic insights into the molecular basis of atherosclerosis. Cell Metab 6:164–179
8. Dallinga-Thie GM, Zonneveld-de Boer AJ, van Vark-van der Zee LC, van Haperen R, van Gent T, Jansen H, De Crom R, van Tol A (2007) Appraisal of hepatic lipase and lipoprotein lipase activities in mice. J Lipid Res 48:2788–2791
9. Dansky HM, Shu P, Donavan M, Montagno J, Nagle DL, Smutko JS, Roy N, Whiteing S, Barrios J, McBride TJ, Smith JD, Duyk G, Breslow JL, Moore KJ (2002) A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse. Genetics 160:1599–1608
10. DeSantis DA, Lee P, Doerner SK, Ko CW, Kawasoe JH, Hill-Baskin AE, Ernest SR, Bhargava P, Hur KY, Cresci GA, Pritchard MT, Lee CH, Nagy LE, Nadeau JH, Croniger CM (2013) Genetic resistance to liver fibrosis on A/J mouse chromosome 17. Alcohol Clin Exp Res 37:1668–1679
11. Drong AW, Lindgren CM, McCarthy MI (2012) The genetic and epigenetic basis of type 2 diabetes and obesity. Clin Pharmacol Ther 92:707–715
12. Elia M, Livesey G (1992) Energy expenditure and fuel selection in biological systems: the theory and practice of calculations based on indirect calorimetry and tracer methods. World Rev Nutr Diet 70:68–131
13. Gelling RW, Yan W, Al-Noori S, Pardini A, Morton GJ, Ogimoto K, Schwartz MW, Dempsey PJ (2008) Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology 149:6053–6064
14. Gregorova S, Divina P, Storchova R, Trachtulec Z, Fotopulosova V, Svenson KL, Donahue LR, Paigen B, Forejt J (2008) Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res 18:509–515
15. Guyenet SJ, Schwartz MW (2012) Clinical review: regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab 97:745–755
16. Hewing B, Fisher EA (2012) Preclinical mouse models and methods for the discovery of the causes and treatments of atherosclerosis. Expert Opin Drug Discov 7:207–216
17. Hoover-Plow J, Shchurin A, Hart E, Sha J, Hill AE, Singer JB, Nadeau JH (2006) Genetic background determines response to hemostasis and thrombosis. BMC Blood Disord 6:6
18. Hsu J, Smith JD (2013) Genetic-genomic replication to identify candidate mouse atherosclerosis modifier genes. J Am Heart Assoc 2:e005421
19. Kaiyala KJ, Morton GJ, Leroux BG, Ogimoto K, Wisse B, Schwartz MW (2010) Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes 59:1657–1666
20. Krewson TD, Supelak PJ, Hill AE, Singer JB, Lander ES, Nadeau JH, Palmert MR (2004) Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains. Endocrinology 145:4447–4451
21. Kuhel DG, Zhu B, Witte DP, Hui DY (2002) Distinction in genetic determinants for injury-induced neointimal hyperplasia and diet-induced atherosclerosis in inbred mice. Arterioscler Thromb Vasc Biol 22:955–960
22. Kunjathoor VV, Wilson DL, LeBoeuf RC (1996) Increased atherosclerosis in streptozotocin-induced diabetic mice. J Clin Investig 97:1767–1773
23. Larson-Hall J (2010) A guide to doing statistics in second language research using SPSS. Routledge, New York
24. Lusis AJ (2000) Atherosclerosis. Nature 407:233–241
25. Lusis AJ, Fogelman AM, Fonarow GC (2004) Genetic basis of atherosclerosis: part II: clinical implications. Circulation 110:2066–2071
26. Mathes WF, Aylor DL, Miller DR, Churchill GA, Chesler EJ, de Villena FP, Threadgill DW, Pomp D (2011) Architecture of energy balance traits in emerging lines of the collaborative cross. Am J Physiol Endocrinol Metab 300:E1124–E1134
27. McLean JA, Tobin G (1987) Animal and human calorimetry. Cambridge University Press, Cambridge
28. McMillen TS, Heinecke JW, LeBoeuf RC (2005) Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice. Circulation 111:2798–2804
29. Millward CA, Burrage LC, Shao H, Sinasac DS, Kawasoe JH, Hill-Baskin AE, Ernest SR, Gornicka A, Hsieh CW, Pisano S, Nadeau JH, Croniger CM (2009) Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17. Mamm Genome 20:71–82
30. Movat HZ (1955) Demonstration of all connective tissue elements in a single section; pentachrome stains. AMA Arch Pathol 60:289–295
31. Murea M, Ma L, Freedman BI (2012) Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. Rev Diabet Stud 9:6–22
32. Nadeau JH, Topol EJ (2006) The genetics of health. Nat Genet 38:1095–1098
33. Nadeau JH, Forejt J, Takada T, Shiroishi T (2012) Chromosome substitution strains: gene discovery, functional analysis, and systems studies. Mamm Genome 23:693–705
34. Nishina PM, Verstuyft J, Paigen B (1990) Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res 31:859–869
35. Nishina PM, Wang J, Toyofuku W, Kuypers FA, Ishida BY, Paigen B (1993) Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28:599–605
36. Paigen B, Morrow A, Brandon C, Mitchell D, Holmes P (1985) Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57:65–73
37. Paigen B, Holmes PA, Mitchell D, Albee D (1987a) Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H. Atherosclerosis 64:215–221
38. Paigen B, Mitchell D, Reue K, Morrow A, Lusis AJ, LeBoeuf RC (1987b) Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc Natl Acad Sci USA 84:3763–3767
39. Pamir N, McMillen TS, Kaiyala KJ, Schwartz MW, LeBoeuf RC (2009) Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status. Endocrinology 150:4124–4134
40. Prows DR, Hafertepen AP, Winterberg AV, Gibbons WJ Jr, Liu C, Nick TG (2007) Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice. Physiol Genomics 30:271–281
41. Rebuffe-Scrive M, Surwit R, Feinglos M, Kuhn C, Rodin J (1993) Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus. Metab Clin Exp 42:1405–1409
42. Sarruf DA, Thaler JP, Morton GJ, German J, Fischer JD, Ogimoto K, Schwartz MW (2010) Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes 59:1817–1824
43. Schreyer SA, Vick C, Lystig TC, Mystkowski P, LeBoeuf RC (2002) LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metab 282:E207–E214
44. Schwartz MW (2006) Central nervous system regulation of food intake. Obesity 14(Suppl 1):1S–8S
45. Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O’Brien W, Courtland HW, Jepsen KJ, Kirby A, Kulbokas EJ, Daly MJ, Broman KW, Lander ES, Nadeau JH (2008) Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci USA 105:19910–19914
46. Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O’Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH (2004) Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304:445–448
47. Smith JD, Bhasin JM, Baglione J, Settle M, Xu Y, Barnard J (2006) Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol 26:597–603
48. Speakman JR (2013) Measuring energy metabolism in the mouse—theoretical, practical, and analytical considerations. Front Physiol 4:34
49. Spiezio SH, Takada T, Shiroishi T, Nadeau JH (2012) Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice. BMC Genet 13:38
50. Stefan M, Nicholls RD (2004) What have rare genetic syndromes taught us about the pathophysiology of the common forms of obesity? Curr DiabRep 4:143–150
51. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN (1988) Diet-induced type II diabetes in C57BL/6J mice. Diabetes 37:1163–1167
52. Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn CM, Rebuffe-Scrive M (1995) Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metab Clin Exp 44:645–651
53. Taicher GZ, Tinsley FC, Reiderman A, Heiman ML (2003) Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis. Anal Bioanal Chem 377:990–1002
54. Takada T, Mita A, Maeno A, Sakai T, Shitara H, Kikkawa Y, Moriwaki K, Yonekawa H, Shiroishi T (2008) Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits. Genome Res 18:500–508
55. Taylor BA, Wnek C, Schroeder D, Phillips SJ (2001) Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains. Mamm Genome 12:95–103
56. Teupser D, Tan M, Persky AD, Breslow JL (2006) Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor−/−mice. Proc Natl Acad Sci USA 103:123–128
57. Thaisz J, Tsaih SW, Feng M, Philip VM, Zhang Y, Yanas L, Sheehan S, Xu L, Miller DR, Paigen B, Chesler EJ, Churchill GA, Dipetrillo K (2012) Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations. Am J Physiol Renal Physiol 303:F972–F981
58. Tinsley FC, Taicher GZ, Heiman ML (2004) Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obes Res 12:150–160
59. van Klinken JB, van den Berg SA, van Dijk KW (2013) Practical aspects of estimating energy components in rodents. Front Physiol 4:94
60. Wang X, Gargalovic P, Wong J, Gu JL, Wu X, Qi H, Wen P, Xi L, Tan B, Gogliotti R, Castellani LW, Chatterjee A, Lusis AJ (2004) Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis. Arterioscler Thromb Vasc Biol 24:1928–1934
61. Wang X, Ria M, Kelmenson PM, Eriksson P, Higgins DC, Samnegard A, Petros C, Rollins J, Bennet AM, Wiman B, de Faire U, Wennberg C, Olsson PG, Ishii N, Sugamura K, Hamsten A, Forsman-Semb K, Lagercrantz J, Paigen B (2005) Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet 37:365–372
62. Wang S, Yehya N, Schadt EE, Wang H, Drake TA, Lusis AJ (2006) Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet 2:e15
63. Weiss JN, Karma A, MacLellan WR, Deng M, Rau CD, Rees CM, Wang J, Wisniewski N, Eskin E, Horvath S, Qu Z, Wang Y, Lusis AJ (2012) “Good enough solutions” and the genetics of complex diseases. Circ Res 111:493–504
64. Welsh CE, Miller DR, Manly KF, Wang J, McMillan L, Morahan G, Mott R, Iraqi FA, Threadgill DW, de Villena FP (2012) Status and access to the collaborative cross population. Mamm Genome 23:706–712
65. West DB, Goudey-Lefevre J, York B, Truett GE (1994a) Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Investig 94:1410–1416
66. West DB, Waguespack J, York B, Goudey-Lefevre J, Price RA (1994b) Genetics of dietary obesity in AKR/J × SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mamm Genome 5:546–552
67. Yang X, Peterson L, Thieringer R, Deignan JL, Wang X, Zhu J, Wang S, Zhong H, Stepaniants S, Beaulaurier J, Wang IM, Rosa R, Cumiskey AM, Luo JM, Luo Q, Shah K, Xiao J, Nickle D, Plump A, Schadt EE, Lusis AJ, Lum PY (2010) Identification and validation of genes affecting aortic lesions in mice. J Clin Investig 120:2414–2422
68. Yazbek SN, Spiezio SH, Nadeau JH, Buchner DA (2010) Ancestral paternal genotype controls body weight and food intake for multiple generations. Hum Mol Genet 19:4134–4144
69. Yazbek SN, Buchner DA, Geisinger JM, Burrage LC, Spiezio SH, Zentner GE, Hsieh CW, Scacheri PC, Croniger CM, Nadeau JH (2011) Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis. Genome Res 21:1065–1073